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A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Cortical microcircuits research group

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Temporal lobe epilepsy (TLE) is one of the most common neurological disorders.  A significant portion of cases do not respond to drug therapy, constituting a major decrease in quality of life for patients.  During seizures, certain parts of the brain produce recurrent, over-synchronized brain rhythms, and typically the more the pathological oscillation spreads throughout the brain, the more severe the symptoms are. In temporal lobe epilepsy, seizures start in a brain region that is responsible for memory and navigation. Therefore, TLE patients also suffer from memory and navigation deficits, further emphasizing the need for new treatment strategies.

While much research on genetic and cellular factors underlying epilepsy is currently underway, fewer studies have investigated how the timing of activity in certain building blocks—the neurons—of the brain change in epileptic patients, especially before and during seizures.  The scope of our research is to learn how individual neurons change their rhythmic activities in epilepsy and importantly, how their connectivity is altered compared to healthy neuronal networks. Until recently, technical limitations prevented the collection of these data without disrupting the activity of individual cells with invasive measurements. It is critical to understand both the normal activity of these brain areas and how certain neuronal cell types may suddenly convert these normal rhythms into an uncontrollable synchronous discharge pattern.
In vivo juxtacellular/ in vitro patch-clamp/optogenetic methods are used in the laboratory in order to interrogate the roles of diverse neuronal types in seizure generation. The outcome of our research will potentially help to develop novel epilepsy treatment paradigms which intervene in seizure generation time specifically rather continuously like an oral medication, helping to decrease long lasting effects of medication on normal brain function.

more at www.vargalab.com

Selected publications:

Varga C, Tamas G, Barzo P, Olah S, Somogyi P. Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex. Cereb. Cortex (2015) pii: bhv045

Varga C., Oijala M., Lish J., Szabo GG., Bezaire M., Marchionni I., Golshani P., Soltesz I., Functional fission of parvalbumin interneuron classes during fast network events. eLife (2014) e04006

Varga, C., Golshani, P., Soltesz, I., Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice, PNAS, 109(40): E2726-34 (2012)

Varga, C., Lee, S. Y., Soltesz, I., Target-selective GABAergic control of entorhinal cortex output, Nature Neuroscience, 13(7):822-4: (2010)

 

Nemzeti Agykutatás Program (NAP-B pályázat)
http://www.agykutatas.com/

 

please visit www.vargalab.com

Cortical microcircuits research group

Cortical microcircuits research group