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A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Molecular Neuroendocrinology Research Group

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The limbic system plays pivotal role in the maintenance of homeostasis and regulation of motivation, emotion, learning and memory processes. Our investigations aim to unravel new limbic forebrain neuronal and neurohumoral mechanisms of the central homeostatic control in healthy and disease state conditions using multidisciplinary approaches such as in vivo microelectrophysiology, combined behavioral-neurochemical paradigms, molecular biology, transgenic technology, immunohistochemistry and single molecule imaging. In addition to elucidate new regulatory processes and so far unknown pathomechanisms, we believe that our research approach enables us to identify new molecular targets in the brain and opens new avenue in development of novel lead compounds. We place particular emphasis on investigations exploring the effect of steroid hormones in the basal forebrain in physiological and neurodegenerative processes. In these experiments, we study the neuroprotective effect of estrogen in basal forebrain cholinergic neurons in Alzheimer’s disease using single molecule detection microscopy and transgenic technology.

Kovács, A., K. László, R. Gálosi, K. Tóth, T. Ollmann, L. Péczely, L. Lénárd: Microinjections of RFRP-1 in the central nucleus of amygdala decreases food intake in the rat. Brain Research Bulletin, 2012, 88: 589-595.

László, K., K. Tóth, E. Kertes, L. Péczely, T. Ollmann, A. Madarassy-Szűcs, L. Lénárd: The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala. Behavioural Brain Research, 2012, 226: 597-600.

Lénárd, L., Z. Karádi: Regulatory processes of hunger motivated behavior. Acta Biologica Hungarica, 2012, 63: 80-88.

Nagy, B., I. Szabó, Sz. Papp, G. Takács, Cs. Szalay, Z. Karádi: Glucose-monitoring neurons in the mediodorsal prefrontal cortex. Brain Research, 2012, 1444: 38-44,.

Kwakowsky A, Herbison AE, Ábrahám IM. The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons. J Neurosci., 2012, 32:11309-17.

Szego EM, Barabás K, Balog J, Szilágyi N, Korach KS, Juhász G, Ábrahám IM.
Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. J Neurosci., 2006, 26:4104-10.

Ábrahám IM, Han SK, Todman MG, Korach KS, Herbison AE. Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci., 2003, 23:5771-7.

  • Development of novel in vivo microelectrophysiological and neurochemical examination techniques
  • Development of single molecule detection microscopy systems

Olympus fiber total internal reflection fluorescence microscope for single molecule detection.