About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Regenerative science, sport and medicina research group

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The primary focus of our research team is to reveal and investigate molecules and pathways critical for organ regeneration and repair in humans.

Our pursuit embraces a wide spectrum of research areas such as regenerative science, sport and medicine where the fields are conjoint in a three dimensional approach: health. The umbrella term regenerative medicine covers the rejuvenation of the heart, traumatized outer/inner ear, skeletal muscle and tendons. Sport reflects the complex spectrum of biochemical processes during physical exercise and mental stress supporting a search for novel drug candidates associated with regenerative medicine. Thus, a translational approach of enhancing quality of life by understanding the very concept of regeneration is at the epicenter of our program.

Heart disease is the predominant cause of disability and death in industrialized nations of the world. Although more commonly affecting adults, heart disease in children is also the leading non-infectious cause of death in the first year of life and often involves abnormalities in cardiac cell specification, migration and survival. Since the heart is incapable of sufficient regeneration, immense efforts have been devoted to promote cardiac repair. Use of stem cells to repopulate damaged cardiac tissue is promising, but is currently limited by technical considerations. As an alternative approach we hypothesize utilizing small, secreted molecules may be a potential alternative to stimulate regeneration, averting technical hurdles associated with stem cell therapy applications. Previously we discovered, external administration of Thymosin beta-4 (TB4), a 43 amino acid peptide and its four amino acid C-terminal variable domain promote myocardial cell migration and survival in embryonic tissues in vitro, and retain this property after birth (Bock-Marquette, I. et al. Nature. 432, 466-72. 2004; Bock-Marquette I. et al. JMCC. 87:113-125. 2015). With the discovery of TB4’s regenerative capacities, we hypothesize additional organs and tissues might react equally to the peptide or to its domain combinations following injury. Accordingly, tissues, like tendons and the tympanic membrane are being currently tested for regenerative purposes. In collaboration with Dr. Tibor Mintal, traumatized tendons are replaced and regenerated by a new method utilizing cadaver grafts. To avoid immunogenic or necrotic reactions in the host, we utilize a process called decellularization. The process eliminates cells in the postmortem tissue whilst keeping the extracellular matrix (ECM). The host ECM acts as a scaffold for progenitor cells and special peptides to inhabit, thereby creating a host-friendly environment. In collaboration with Dr. Peter Bako we are currently testing the effect of TB4 on tympanic membrane repair. Our ultimate goal is to extend our focus on the injuries of the inner ear. Moreover, in collaboration with Dr. Szilard Rendeki, we are analyzing the molecular alterations initiated by blunt chest injuries in a rodent model and in humans. We predict to identify novel molecular markers to support clinical diagnosis and treatment of lung traumas.  Simultaneously, mesenchymal stem cell transformation into human cardiac myocytes utilizing our identified potential peptides is currently being tested. Micropeptides and CRISPR technology are on the verge of R&D.

Sport, as physical activity plays a vital role in improving the quality of life. Numerous studies and common sense support this hypothesis. Identification of potential exercise-initiated small molecules in support of organ regeneration and repair in humans is aimed to discover complex physiological, psychological and biochemical responses due to extreme and recreational physical load. Our results indicate protein expression profile is indeed significantly altered in human blood plasma and saliva samples following physical and/or psychological stress. Our investigations are supported by new generation sequencing (NGS), 2D-electrophoresis and mass spectrometry analyses and resulted in identification of numerous promising protein candidates for clinical utilization.

Finally, beside organ regeneration, there is an additional special component to our research team. A novel, multi-level early-stage screening program for lung cancer, a leading cause of death within cancerous mortality was developed and transcribed into a national public health program via a law proposal. The proposal supports early, cost-efficient means of public health initiative greatly reducing mortality whilst improving quality of life, workforce and subsequently national GDP.



Halász Heléna
laboratóriumi technikus

Dr. Tapodi Antal
adjunktus
Antal.Tapodi@aok.pte.hu
+36 72 536001 /31656
Erős Krisztián
tudományos segédmunkatárs

Nem került feltöltésre publikáció...
CONTACT
Dr. Bock-Marquette Ildikó
Research Group Leader