About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Cellular Neurobiology Research Group

  • Research concept
  • Members
  • Publications
  • Awarded projects
  • Galleries

The main strength of the research group is the interdisciplinary approach of various biological questions.  Hence many of the projects are performed in collaboration. Most of the projects are focused on the investigation of connectivity and function of brain areas (especially the cortex and the hippocampus) using anatomical and electrophysiological methods. We investigate the functional connectivity of these brain areas in normal and epileptic brain and also the change that is caused by the altered oxygen concentration (hyperoxia and hypoxia). The development of a new microscopy method to visualize gene transcription (visual genetics) in live cells is also in the portfolio of the lab.

Apart from the neuronal network investigation we investigate heart activity in zebrafish embryos using electrophysiology. We use normal and genetically modified animals that mimic human heart conditions to uncover ways to find cure to various heart diseases. We also develop a high throughput method to record heart and brain activities in parallel from zebrafish embryos. This method can be used in drug discovery, drug safety and environmental toxicity analysis. We also develop and use various bioinformatic tools to analyse images and brain and heart waves.



Haseeb Qureshi
assistant research fellow

Renáta Gajdics-Dóró
laboratory assistant
doro.renata@pte.hu
Dr. Ferenc Budán
research fellow

Dr. Andor Magony
research fellow
magony.andor@pte.hu
Marcell Dénes
laboratory technician
denes.marcell@pte.hu

Selected best papers

  • X.Shang, X.Ji, J.Dang, L.Wang, C.Sun, K.Liu, A.Sík, M.Jin (2020): α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish Toxicology Letters 324, 1-11

  • M.Jin, B.Zhang, Y.Sun, S.Zhang, X.Li, A.Sík, Y.Bai, X.Zheng, K.Liu (2020): Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish Neuropharmacology 162, 107760

  • M.Jin, D.Gao, R.Wang, A.Sík and K.Liu (2020) Possible involvement of TGF-β-SMAD-mediated epithelial-mesenchymal transition in pro-metastatic property of PAX6 Oncol Reports 44(2) 555-564

  • W.Sheng, S.Weng,  A.Sík, and K.Liu (2019): Cellular localization of melatonin receptor Mel1b in pigeon retina Neuropeptides78, 101974

  • B.Zhang, L.Wang, X.Ji, S.Zhang, R.Wang, J.Dang, K.Liu, A.Sík and M.Jin (2019): Anti-inflammatory associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures in Zebrafish Food & Function 11 (2), 1425-1440

  • Y.Hadzhiev, H.Qureshi, L.Wheatley, L.Cooper, A.Jasiulewicz, H.V.Nguyen, J Wragg, D.Poovathumkadavil, S.Conic, S.Bajan, A.Sík, G.Hutvàgner, L.Tora, A.Gambus, J.Fossey, and F.Müller (2019) A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activation Nature Communication  10(1):691. doi: 10.1038/s41467-019-08487-5

  •  J.Crowcombe, S.Dhillon, R.Hurst, F.Muller, S.Egginton,  A.Sik* and E.Tarte (2016): 3D finite element electrical model of larval zebrafish ECG signals Plos One DOI: 10.1371/journal.pone.0165655; * co-corresponding author
  • S.S.Dhillon, E.Doro, I.Magyary, S.Egginton,  A.Sík* and F.Müller (2013) Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs Plos One, * co-corresponding author; 8(4):e60552

  • D.Kroeger, A.Tamburri, F.Amzica and A.Sík (2010) Activity dependent layer-specific changes in the extracellular chloride concentration and chloride driving force in the rat hippocampus J.Neurophysiology 103: 1905-1914

  • M.Urushitani, A.Sík, T.Sakurai, N.Nukina, R.Takahashi and J.P.Julien (2006): Chromogranin-mediated secretion of ALS-linked superoxide dismutase mutants: a novel pathway to inflammation and motor neuron death Nature Neurosci., 9(1):108-18 

  • B.Kocsis, V.Varga,  L.Dahan and A.Sík (2006): Serotonergic neuron diversity: identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm Proc.Natl.Acad.Sci. USA, 103(4):1059-64

  • S.Li, V.Varga, A.Sík and B.Kocsis (2005) GABAergic control of the ascending serotonergic input to the limbic system J.Neurophysiol, 94:2561-2574

  • J.A.M.Coull, D.Boudreau, K.Bachand, S.A.Prescott, F.Nault, A.Sík, P.De Koninck and Y. De Koninck (2003) Transsynaptic shift in anionic gradient in spinal lamina I neurons as a novel mechanism of a painful peripheral neuropathy. Nature  424(6951):938-42

  • A.Sík, N.Hájos, A.Gulácsi, I.Mody and T.F.Freund (1998) The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. Proc.Natl.Acad.Sci. USA, 95(6):3245-3250

  • A.Sík, A. Ylinen, M. Penttonen and G. Buzsaki (1994) Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science, 265(5179):1772-177

  • A.Sík, M.Penttonen, A. Ylinen and G. Buzsaki (1995) Hippocampal CA1 interneurons: An in vivo intracellular labeling study. J.Neurosci., 15(10):6651-6665 

2016-2020 Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real time in intact nervous system by 4D Raman spectroscopy, Horizon 2020, €4.27M, consortium leader

2017-2022 Transcribing the processes of life: Visual Genetics, H2020 Marie Sklodowska-Curie Research and Innovation Staff Exchange, €1.29M, consortium leader

2019-         Higher Education Centre of Excellence Programme, 10M HUF/year, participant

2019-          Tématerületi Kiválósági Program, Innovation leader, participant

CONTACT
Prof. Dr. Attila Sík
Research Group Leader
 29032