About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Molecular Neuroendocrinology Research Group

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  • Members
  • Publications
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Our research group investigates the effect of estrogen on neurons in the brain. Estrogen secreted from the ovary, as a classical feedback molecule, alters the function of several neuronal phenotypes. Although estrogen is primarily thought to alter the neuronal activity via modulating gene expression directly, it also exerts “non-classical” effects on neurons by altering signal transduction pathways. In our laboratory, we systematically characterize the mechanism and role of estrogen-induced “non-classical” effect on signalling molecules in neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection and transgenic technology.



Dr. Géza Makkai
research fellow
makkai.geza@pte.hu
Dr. Tibor Zoltán Jánosi
research fellow
janosi.tibor@pte.hu
Dr. Klaudia Barabás
assistant professor
klaudia.barabas@aok.pte.hu
29033
Soma Godó
PhD student
soma.godo@aok.pte.hu
29033
Dr. Dávid Ernszt
research fellow
ernszt.david@pte.hu
36245
Dr. Tamás Kovács
research fellow
tamas.kovacs@aok.pte.hu
36245
Dr. Gergely Kovács
senior research fellow
gergely.kovacs@aok.pte.hu
29301
Szidónia Farkas
PhD student
szidonia.farkas@aok.pte.hu
36245
Ildikó Sabáliné Udvarácz
laboratory assistant
ildiko.udvaracz@aok.pte.hu
31747
Zsófia Harsányi
laboratory assistant
zsofia.harsanyi@aok.pte.hu
31747
Dr. Ferenc Lengyel
assistant professor
ferenc.lengyel@aok.pte.hu
31747
Dr. Erzsébet Kövesdi
assistant professor
kovesdi.erzsebet@pte.hu
29301
Kinga Marosi
laboratory technician
kinga.marosi@aok.pte.hu
31455, 31738
Bence Petrovai
laboratory technician
petrovai.bence@pte.hu
31455
Dr. Diána Feller
research fellow
feller.diana@pte.hu
31746

Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression. Tamás Kovács , Edina Szabó-Meleg , István M Ábrahám  Int J Mol Sci. 2020 Apr 30;21(9):E3177. doi: 10.3390/ijms21093177.

Effect of inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences.  Barabás K, Szabó-Meleg E, Ábrahám IM. Int J Mol Sci. 2020 Jan 14;21(2):529. doi: 10.3390/ijms21020529.

The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo. Barabás K, Barad Z, Dénes Á, Bhattarai JP, Han SK, Kiss E, Sármay G, Ábrahám IM, eNeuro, 2018 Oct 15;5(5)

Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons. Barabás K, Godó S, Lengyel F, Ernszt D, Pál J, Ábrahám IM, Horm Behav. 2018 Aug;104:183-191. doi: 10.1016/j.yhbeh.2018.05.008. Epub 2018 May 19.

The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons. Kwakowsky A, Herbison AE, Ábrahám IM. J Neurosci., 2012, 32:11309-17.

Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. Szego EM, Barabás K, Balog J, Szilágyi N, Korach KS, Juhász G, Ábrahám IM. J Neurosci., 2006, 26:4104-10.

Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. Ábrahám IM, Han SK, Todman MG, Korach KS, Herbison AE. J Neurosci., 2003, 23:5771-7.

Laboratory equipments and methods:

  • TIRF microscopy (Total Internal Reflection Fluorescence Mycroscopy, Olympus) 
  • STED microscopy (Stimulated Emission Depletion microscopy, NIKON)
  • N-STORM (Stochastic Optical Reconstruction Microscopy, NIKON)
  • 3D-SMDM (3-dimensional single-molecule detection)
  • SIM (Structured Illumination Microscopy, ZEISS)
  • In vivo 2-photon microscopy
  • In vitro 2-photon microscopy
  • Electrophysiological set-up with Ca2+ imaging
  • Digital Stereotaxic Frame
  • Molecular biology techniques (PCR, molecular cloning, CRISPR-Cas9)
CONTACT
Dr. István Ábrahám
Research Group Leader