A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
Our research group investigates the effect of estrogen on neurons in the brain. Estrogen secreted from the ovary, as a classical feedback molecule, alters the function of several neuronal phenotypes. Although estrogen is primarily thought to alter the neuronal activity via modulating gene expression directly, it also exerts “non-classical” effects on neurons by altering signal transduction pathways. In our laboratory, we systematically characterize the mechanism and role of estrogen-induced “non-classical” effect on signalling molecules in neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection and transgenic technology.
Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression. Tamás Kovács , Edina Szabó-Meleg , István M Ábrahám Int J Mol Sci. 2020 Apr 30;21(9):E3177. doi: 10.3390/ijms21093177.
Effect of inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences. Barabás K, Szabó-Meleg E, Ábrahám IM. Int J Mol Sci. 2020 Jan 14;21(2):529. doi: 10.3390/ijms21020529.
The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo. Barabás K, Barad Z, Dénes Á, Bhattarai JP, Han SK, Kiss E, Sármay G, Ábrahám IM, eNeuro, 2018 Oct 15;5(5)
Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons. Barabás K, Godó S, Lengyel F, Ernszt D, Pál J, Ábrahám IM, Horm Behav. 2018 Aug;104:183-191. doi: 10.1016/j.yhbeh.2018.05.008. Epub 2018 May 19.
The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons. Kwakowsky A, Herbison AE, Ábrahám IM. J Neurosci., 2012, 32:11309-17.
Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. Szego EM, Barabás K, Balog J, Szilágyi N, Korach KS, Juhász G, Ábrahám IM. J Neurosci., 2006, 26:4104-10.
Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. Ábrahám IM, Han SK, Todman MG, Korach KS, Herbison AE. J Neurosci., 2003, 23:5771-7.
Laboratory equipments and methods:
