About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...



Green chemistry research group

  • Research concept
  • Members
  • Publications
  • Awarded projects
  • R and D results
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The dendrimers are one of the most important nanosize building blocks. Their technological and practical applications are also remarkable. Beside the industrial use of the dendrimers gain wide application also in pharmacology. The efforts aiming at the development of dendrimers, among them our present research, are focused on the synthesis of those ones able to form inclusion derivatives with the target compunds.

The first poly(amido)amidoamine (’PAMAM’) dendrimers were followed by more complicated structures containing further heteroatoms, cross-linkings and graphite-like substructures.

Our target compounds are the so-called host dendrimers which may gain application both in pharmacology and analytical chemistry.

The topics to be investigated

  • One of our goals is the synthesis of dendrimers containing either novel trisubstituted core or tetravinyl/tetraallylsilanes. Homogeneous catalysts of high chemo- and regioselectivities will be used. The preparation of higher generation dendrimers will be carried out by divergent methodologies, i.e., methodologies starting from the core unit.
  • The homogeneous catalysts will be exploited in the synthesis of amide-functionalised dendrimers, i.e., the synthesis of conventional structures will be carried out by novel reactions of high selectivity. On the other side, transition metal catalysed cross-coupling reactions will be used for the synthesis of novel dendritic structures.
  • Our basic compounds, serving as core derivatives, are 1,3,5-triiodobenzene, 2,4,6-triiodoaniline and silanes containing alkene functionalities. The iodoarene-type substrates and the silane derivatives are promising substrates in high-yielding carbonylation, coupling and hydroformylation reactions, respectively.



  1. T. Kálai, B. Bognár, D. Zsolnai, Z. Berente, K. Hideg:
    Synthesis of Nitroxide annulated carbocycles and heterocycles
    Synthesis  44 (2012), 3655-3660.
  2. Takács, A. Czompa, G. Krajsovszky, P. Mátyus, L. Kollár:
    Functionalization of the pyridazin-3(2H)-one ring via palladium-catalysed aminocarbonylation.
    Tetrahedron 68 (2012) 7855-7860.
  3. E. Bálint, E. Fazekas, P. Pongrácz, L. Kollár, L. Drahos, T. Holczbauer, M. Czugler, Gy. Keglevich:
    N-Benzyl and N-Aryl Bis(Phospha-Mannich Adducts): Synthesis and Catalytic Activity of the Related Bidentate Chelate Platinum Complexes in Hydroformylation.
    J. Organomet. Chem. 717 (2012) 75-82.
  4. E. Szánti-Pintér, Z. Csók, L. Kollár, K. Vékey, R. Skoda-Földes: 
    Synthesis of ferrocene-labelled steroid derivatives via homogeneous catalytic methods.
    J. Organomet. Chem. 718 (2012) 105-107.
  5. B. Barcs, L. Kollár, T. Kégl:
    Density functional study on the mechanism of nickel mediated diazo carbonylation.
    Organometallics 31 (2012) 8082-8097.
  6. J. M. Tukacs, D. Király, A. Stradi, G. Novodarszki, Z. Eke, G. Dibo, T. Kégl, L. T. Mika:
    Efficient catalytic hydrogenation of levulinic acid: a key step in biomass conversion
    Green Chem., 14, (2012), 2057-2065.
  7. L. Xu, G. Csekő, T. Kégl, A. K. Horváth:
    General Pathway of Sulfur-Chain Breakage of Polythionates by Iodine Confirmed by the Kinetics and Mechanism of the Pentathionate-Iodine Reaction
    Inorg. Chem., 51, (2012), 7837-7843.
  8. Y. Li, Zs. Csók, L. Kollár, K. Iwata, E. Szász, S. Kunsági-Máté:
    The role of the solvation shell decomposition of alkali metal ions in their selective complexation by resorcinarene and its cavitand
    Supramolecular Chemistry 24 (2012) 374-378.
  9. Zs. Czibulya, L. Kollár, M. P. Nikfardjam, S. Kunsági-Máté: 
    The Effect of Temperature on the Color of Red Wines
    J. Food Science 77(8) (2012) 880-885.
  10. E. Horváth, N. Kálmán, M. Pesti, K. Iwata, S. Kunsági-Máté: 
    Thermodynamic and kinetic processes during the unfolding of BSA in the presence of the mycotoxin patulin
    Acta Biologica Hungarica 63(3) (2012) 389–398.
  11. M. Poór, S. Kunsági-Máté, T. Bencsik, J. Petrik, S. Vladimir-Knežević, T. Kőszegi:
    Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: A new possible mode of action
    Int. J.  Biol. Macromol. 51 (2012) 279-283.


  1. R. Farkas, E. A. Molnár, A. Takács, L. Kollár:
    High-yielding Synthesis of 1-Carboxamido-3,4-dihydronaphthalenes via Palladium-catalysed Aminocarbonylation.
    Tetrahedron 69 (2013) 500-504.
  2. P. Pongrácz, I. D. Kostas, L. Kollár:
    Platinum complexes of P,N and P,N,P-ligands and their application in the hydroformylation of styrene.
    J. Organomet. Chem. 723 (2013) 149-153.
  3. R. M. B. Carrilho, M. M. Pereira, M. J. S. M. Moreno, A. Takács, L. Kollár:
    A new facile synthesis of steroidal dimers containing 17,17’-dicarboxamide spacers.
    Tetrahedron Lett. 54 (2013) 2763-2765.
  4. M. Kiss, N. Pálinkás, A. Takács, S. Mahó, L. Kollár:
    A systematic approach to the synthesis of androstane-based 3,17-dicarboxamides (homo- and mixed dicarboxamides) via palladium-catalyzed aminocarbonylation.
    Steroids 78 (2013) 693-699.
  5. Takács A., Farkas R., Kiss M., Petz A., Csók Zs., Kollár L.:
    Palládium-katalizált aminokarbonilezési reakciók. (Palladium-catalysed aminocarbonylation reations.)
    Magy. Kém. Folyóirat 119 (2013) 120-128.
  6. T. Papp, L. Kollár, T. Kégl:
    Mechanism of the platinum-tin catalysed hydroformylation of styrene: a detailed computational investigation of the chiral discrimination.
    Organometallics 32 (2013) 3640-3650.
  7. E. Szánti-Pintér, Z. Csók, L. Kollár, R. Skoda-Földes:
    Synthesis of Novel 13α-18-nor-16-Carboxamido Steroids via a Palladium-Catalyzed Aminocarbonylation Reaction.
    Steroids 78 (2013) 1177-1182.
  8. Kégl T.:
    Donor-akceptor kölcsönhatások vizsgálata π-komplexekben
    Magy. Kém. Foly. 119, (2013), 110-114
  9. M. Poór, S. Kunsági-Máté, G. Matisz, Y. Li, Zs. Czibulya, B. Peles-Lemli, T. Kőszegi:
    Interaction of alkali andalkaline earth ions with OchratoxinA
    J. Luminescence 135 (2013) 276-280.
  10. Yin Li, P. Huszthy, I. Móczár, B. Szemenyei, S. Kunsági-Máté: 
    Solvent effect on the complex formation of a crown ether derivative with sodium and potassium ions. Thermodynamic background of selectivity
    Chem. Phys. Lett. 556 (2013) 94–97.
  11. H. Li, J. C. Nie, J. C. Li, S. Kunsági-Máté: 
    Ethanol induced formation of graphene fractions suspended in acetonitrile
    Carbon 54 (2013) 495-497.
  12. S. Kunsági-Máté, K. Iwata
    Electron Density Dependent Composition of the Solvation Shell of Phenol Derivatives in Binary Solutions of Water and Ethanol
    Solution Chem. 42 (2013) 165–171.
  13. J. Barroso-Flores, I. Silaghi-Dumitrescu, P. M. Petrar, S. Kunsági-Máté:
    Ab initio calculations of electronic interactions in inclusion complexes of calix- and thiacalix[n]arenes and block s cations
    J. Incl. Phenom. Macrocyclic Chem., 75 (2013) 39–46.
  14. K. Szabó, P. Wang, B. Peles-Lemli, Yan Fang, L. Kollár, S. Kunsági-Máté:
    Structure of aggregate of hydrotropic p-toluene sulfonate and hydroxyacetophenone isomers
    Colloids and Surfaces A: Physicochem. Eng. Aspects 422 (2013) 143– 147.
  15. M. Poór, Yin Li, S. Kunsági-Máté, Zs. Varga, A. Hunyadi, B. Dankó, Fang-Rong Chang, Yang-Chang Wu, T. Kőszegi:
    Protoapigenone derivatives: albumin binding properties and effects on HepG2 cells
    J. Photochem. Photobiol. B – Biology 124 (2013) 20-26.
  16. M. Poór, Yin Li, S. Kunsági-Máté, J. Petrik, S. Vladimir-Knežević, T. Kőszegi:
    Molecular displacement of warfarin from human serum albumin by flavonoid aglycones
    J. Luminescence 142 (2013) 122-127.
  17. M. Poór, S. Kunsági-Máté, Yin Li, T. Kőszegi:
    A new possible mechanism of flavonoid-drug interaction: flavonoids are able to displace warfarin from human serum albumin
    Biochim. Clinica 37 (2013) S249.
  18. Zs. Csók, T. Kégl, Yin Li, R. Skoda-Földes, L. Kiss, S. Kunsági-Máté, M. H. Todd, L. Kollár:
    Synthesis of elongated cavitands via click reactions and their use as chemosensors
    Tetrahedron 69 (2013) 8186-8190.
  19. M. Calugareanu, G. Nagy, A.M. Josceanu, L. Nagy:
    Ion selective electrodes for microalgal biotechnology
    Rev. Chim. 64 (2013) 205-209.
  20. Nagy Lívia, Gyetvai Gergely, Kiss András, Souto Ricardo, Isquerdo Javier, NagyGéza
    Speciális célra szolgáló mikroelektródok kifejlesztése és alkalmazása
    Magy. Kém. Foly. 119 (2013) 104-109
  21. T. Papp, L. Kollár, T. Kégl:
    Employment of Quantum Chemical Descriptors for Hammett Constants: Revision Suggested for the Acetoxy Substituent.
    Chem. Phys. Lett. 588 (2013) 51-56.
  22. N. Mike, G. Papp, M. Certik, Zs. Czibulya, S. Kunsági-Máté, I. Ember, Cs. Vágvölgyi, M. Pesti, Z. Gazdag: 
    Regulation of cytotoxic, non-estrogenic, oxidative stress-induced processes of zearalenone in the fission yeast Schizosaccharomyces pombe.
    Toxicon 73 (2013) 130-143.
  23. B. Peles-Lemli, D. Kánnár, J. C. Nie, H. Li, S. Kunsági-Máté́: 
    Some Unexpected Behavior of the Adsorption of Alkali Metal Ions onto the Graphene Surface under the Effect of External Electric Field.
    J. Phys. Chem. C 117 (2013) 21509-21515.
  24. T. Kégl: 
    DFT study on the Co-Xe bond in the HCo(CO)3 Xe adduct.
    J. Quantum Chem. (2013) 639851.
  25. G. Tollár, T. Kégl: 
    Computational Study on the Intramolecular Carbene-CO coupling in M(CH2)(CO)3 radicals (M=Co, Rh, Ir)
    J. Inorg. Chem., (2013) 639851.
  26. L. Kiss, Z. Őri, L. Nagy, B. Kovács, G. Nagy
    Voltammetric Concentratio measurements in diffusion hindered media
    J. Solid State Electrochem. 17 (2013) 3039-3045



  1. Csók Zs., Kégl T., Kollár L.: 
    Szupramolekuláris kémia, homogén katalízis: nagyszelektivitású reakciók kavitand alapvázakon.
    Magy. Kém. Lapja 69 (2014) 3-6.
  2. M. Gergely, A. Takács, A. Petz, L. Kollár:
    Picolylamines as N-Nucleophiles in the Aminocarbonylation of Iodobenzene and 1-Iodocyclohexene.
    Tetrahedron 70 (2014) 218-224.
  3. T. Papp, L. Kollár, T. Kégl:
    Estimation of Bite Angle Effect on the Electronic Structure of Cobalt-Phosphine Complexes: A QTAIM Study.
    JQuant. Chem. (2014), Article ID 528072;  http://dx.doi.org/10.1155/2014/528072
  4. T. R. Kégl, L. Kollár, T. Kégl:
    Electronic Structure of Ferrocene-Substituted Cavitands. A QTAIM and NBO Study
    JQuant. Chem. (2014), Article ID 521037;  http://dx.doi.org/10.1155/2014/521037
  5. P. Bagi, T. Kovács, T. Szilvási, P. Pongrácz, L. Kollár, L. Drahos, E. Fogassy, G. Keglevich:
    Platinum(II) complexes incorporating racemic and optically active 1-alkyl-3-phospholene P-ligands; Synthesis, stereostructure, NMR properties and catalytic activity.
    J. Organomet. Chem. 751 (2014) 306-313.
  6. P. Pongrácz, T. Papp, L. Kollár, T. Kégl:
    Influence of the 4-Substituents on the Reversal of the Enantioselectivity in the Asymmetric Hydroformylation of 4-Substituted Styrenes with PtCl(SnCl3)[(2S,4S)-BDPP].
    Organometallics 33 (2014) 1389-1396.
  7. T. Z Jánosi, J. Korppi-Tommola, Zs. Csók, L. Kollár, P. Myllyperkiö, J. Erostyák:
    Anthracene fluorescence quenching by a tetrakis(ketocarboxamide)cavitand.
    J. Spectroscopy (2014), Article ID 708739;  http://dx.doi.org/10.1155/2014/708739
  8. Kiss, G. Nagy:
    New SECM scanning algorithms for improved potentiometric imaging of circularly symmetric targets.
    Electrochim. Acta 119 (2014) 169-174.
  9. M. Poór, Yin Li, G. Matisz, L. Kiss, S. Kunsági-Máté, T. Kőszegi:
    Quantitation of species differences in albumin-ligand interactions for bovine, human and rat serum albumins using fluorescence spectroscopy: A test case with some Sudlow's site I ligands,.
    J.  Luminescence 145 (2014) 767-773.
  10. Y. Li, Zs. Czibulya, M. Poór, S. Lecomte, L. Kiss, E. Harte, T. Kőszegi, S. Kunsági-Máté:
    Thermodynamic study of the effects of ethanol on the interaction of ochratoxin A with human serum albumin.
    J. Luminescence 148 (2014) 18-25.
  11. E. Lempel,  Zs. Czibulya, S. KunságiMáté, J. Szalma, B. Sümegi, K. Böddi: 
    Quantification of Conversion Degree and Monomer Elution from Dental Composite Using HPLC and Micro‑Raman Spectroscopy.
    Chromatographia 77 (2014) 1137–1144.
  12. H. Li, J. C. Li, D. Liu, B. Peles-Lemli, S. Kunsági-Máté: 
    Ethanol assisted formation of aligned MWCNT bundles on nanostructured ZnO surface.
    Chem. Phys. Lett. 597 (2014) 36–39.
  13. M. Poór, M. Kuzma, G. Matisz, Y. Li, P. Perjési, S. Kunsági-Máté, T. Kőszegi: 
    Further Aspects of Ochratoxin A-Cation Interactions: Complex Formation with Zinc Ions and a Novel Analytical Application of Ochratoxin A-Magnesium Interaction in the HPLC-FLD System.
    Toxins 6 (2014) 1295-1307.
  14. R. Galindo-Murillo, A. Olmedo-Romero, E. Cruz-Flores, P. M. Petrar, S. Kunsági-Máte, J. Barroso-Flores: 
    Calix[n]arene-based drug carriers: A DFT study of their electronic interactions with a chemotherapeutic agent used against leukemia,
    Comput. Theor. Chem. 1035 (2014) 84-91.
  15. Kégl T.:
    A szén-dioxid sajátos elektronszerkezete
    Magy. Kém. Folyóirat, 120, (2014) 14-16.
  16. T. Kálai, N. Lazsányi, G.  Gulyás-Fekete, K. Hideg:
    Synthesis of nem paramagnetic retinal analogues
    Monatsh. Chem. 145 (2014) 651-656.
  17. Gy. Csekő, Y. Hu, Y. Song, T. R. Kégl, Q. Gao, S. V. Makarov, A. K. Horváth:
    Kinetic Evidence of Tautomerism of Thiourea Dioxide in Aqueous Acidic Solution
    Eur. J. Inorg. Chem., 11 (2014) 1875-1879.
  18. Z. Kabak-Solt, A. Takács, G. Mikle, L. Kollár:
    Alkoxycarbonylpiperidines as N-Nucleophiles in the Palladium-Catalysed Aminocarbonylation.
    Monatsh. Chem. 145 (2014) 1473-1478.
  19. P. Bagi, T. Szilvási, P. Pongrácz, L. Kollár, L. Drahos, G. Keglevich:
    Platinum(II) complexes incorporating racemic and optically active 1-aryl-3-phospholene P-ligands; Synthesis, stereostructure, NMR properties and catalytic activity.
    Curr. Org. Chem.  18 (2014) 1529-1538.
  20. T. Z Jánosi, J. Korppi-Tommola, Zs. Csók, L. Kollár, P. Myllyperkiö, J. Erostyák:
    Anthracene fluorescence quenching by a tetrakis(ketocarboxamide)cavitand.
    J. Spectroscopy (2014), Article ID 708739;  http://dx.doi.org/10.1155/2014/708739
  21. G. Mikle, B. Boros, L. Kollár:
    Diastereoselective Aminocarbonylation of a Steroidal Iodoalkene with 2,2’-Diamino-1,1’-binaphthalene in Palladium-Catalysed Carbonylation.
    Tetrahedron Asymm. 25 (2014) 1527-1531.
  22. Z. Őri, A. A. Ciucu, C. Mihailciuc, C. D. Stefanescu, L. Nagy, A. Kiss, G. Nagy:
    Sensitivity enhancement of a "bananatrode" biosensor for dopamine determination based on SECM studies inside its reaction layer
    Sensors & Actuators: B. Chemical 190 (2014) 149-156
  23. L. Nagy, D. Filotas, M. Boros, G. Pozsgai, E. Pinter, G. Nagy:
    Amperometric cell for subcutaneous detection of hydrogen sulfide (H2S) in anesthetized experimental animals,
    Physiol. Measurements 35 (2014) 2475-2489



  1. B. Bognár, T. Kálai, G. Gulyás-Fekete, N. Lazsányi,  K. Hideg:
    Synthesis of Azoles Condensed with, or Linked to, Nitroxides.
    Synthesis 47 (2015) 985-991.
  2. M. Poór, S. Kunsági-Máté, L. Szente, G. Matisz, Gy. Secenji, Zs. Czibulya, T. Kőszegi:
    Interaction of ochratoxin A with quaternary ammonium beta-cyclodextrin.
    Food Chemistry 172 (2015) 143–149.
  3. G. Matisz, A.-M. Kelterer, W. Fabian, S. Kunsági-Máté: 
    Structural properties of methanol - water binary mixtures within the quantum cluster equilibrium model.
    Phys. Chem. Chem. Phys. 17 (2015) 8467-8479.
  4. M. Kiss, S. Mahó, K. Böddi, B. Boros, L. Kollár:
    Palladium-Catalyzed Diaminocarbonylation. Synthesis of Androstene Dimers Containing 3,3’- or 17,17’-Dicarboxamide Spacers.
    Monatsh. Chem. 146 (2015) 357-364.
  5. D. Filotás, L. NagyR. Skoda-FöldesL. Kollár, G. Nagy:
    Electrochemical experimental study for the characterization of tetraferrocenyl-cavitand, synthesized in click-reaction.
    Electroanalysis 27 (2015) 38-41.
  6. R. M. B. Carrilho, A. R. Almeida, M. Kiss, L. Kollár, R. Skoda-Földes, J. M. Dabrowski, M.J.S.M. Moreno, M. M. Pereira:
    One-step Synthesis of Dicarboxamides through Pd-Catalysed Aminocarbonylation with Diamines as N-Nucleophiles.
    Eur. J. Org. Chem. (2015) 1840-1847.
  7. D. Filotás, L. NagyT. R. Kégl, Z. Csók, L. Kollár, G. Nagy:
    Synthesis and Electrochemical Properties of the Tetraferrocenyl-Cavitand in Dimethyl Formamide solvent Using Platinum and Carbon Working Electrodes.
    Electroanalysis 27 (2015) 799-807.
  8. B. Botz, K. Bölcskey, Á. Kemény, V. Tékus, G. Sétáló, T. Németh, M. Kovács, A. Mócsai, L. Kollár, E. Pintér, Z. Helyes:
    Hydrophobic cyanine dye-doped micelles for the optical in vivo imaging of plasma leakage and vascular disruption.
    J. Biomed. Optics 20, 016022 (2015) (DOI: 10.1117/1.JBO.20.1.016022)
  9. Z. Czibulya, I. Horváth, L. Kollár, M. P. Nikfardjam, S. Kunsági-Máté:
    The effect of temperature, pH, and ionic strength on color stability of red wine.
    Tetrahedron 71 (2015) 3027-3031.
  10. M. Kiss, A. Takács, L. Kollár:
    Highly selective synthesis of carboxamides via transition metal catalysed aminocarbonylation.
    Curr. Green Chem. 000 (2015) 000-000. (accepted)
  11. Z. Nagymihály, L. Kollár:
    High-yielding Synthesis of Deepened Cavitands Bearing Picolyl Moieties on the Upper Rim.
    Tetrahedron 71 (2015) 2555-2560.
  12. Z. Őri, L. Nagy, L. Kiss, B. Kovács, G. Nagy:
    Direct voltammetric determination of ascorbic acid in natural paprika fruits without sample pretreatment.
    Electroanalysis 27(2015) 808–816.
  13. A. Kiss, G. Nagy:
    Deconvolution of potentiometric SECM images recorded with high scan rate.
    Electrochimica Acta, 163 (2015) 303-309.

OTKA K104956: Nitroxidokat és előanyagaikat tartalmazó szenzorok és biomolekulák szintézise (T. Kálai, 18M HUF for 4 years)

OTKA K113177: Homogénkatalitikus aszimmetrikus karbonilezési reakciók és mechanizmus-vizsgálatuk (L. Kollár, 24M HUF for 4 years))

TÉT_12_RO-1-2013-0015: Highly effective voltammetric methods f for monoamine neurotransmitter assessments  in complex biological matrices. (1.6 M HUF)

TÉT_12_RO-1-2013-0018: Mapping of  Nitro-Oxidative Species by Scanning Electrochemical Microscopy with Micro(bio)sensors. (1.3 M HUF)

TÉT_12_CN-1-2012-0040: Modifying lateral strain in III-nitride-based epitaxial layers by selectively patterning sapphire substrates with CNT bundles and graphene fractions (Xiamen University, China, 9.6 M HUF + 0.3 M CNY)

TÁMOP-4.2.2.A-11/1/KONV-2012-0065: Synthesis of supramolecular systems, their investigation and application in sensor chemistry. (170 M HUF) (total: 341M HUF for 2 years), PI: L. Kollár)

  • 210 publications (in international journals, cumulative impact ca. 460); 1900 independent citations
  • 9 basic patents in pharmaceutical and pesticide chemistry (announced in more than 30 countries).
  • 25 years cooperation with Gedeon Richter Pharmaceutical Works Ltd. (steroid chemistry group). Synthesis of novel, diphenyl ether-based pesticides (Budapest Chemical Works). Investigation of the copigmentation in red wines (Vylyan Viticulture).

Chemical industry, pharmaceutical industry

  • Development of carbonylation catalysts of high selectivity.
  • Synthesis of iodo-containing and silane substrates able to form dendritic cores.
  • Structural determination of first- (second-, third-) generation dendrimers.
  • Investigation of the practical application of dendrimers.
  • Laboratory devices necessary to carry out synthesis of dendrimers (inert Schlenk-technique, high-pressure autoclaves)
  • Analytical methods (400 MHz NMR, FT-IR-Raman, MS, fluorimetric methods)

Green chemistry research group