A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...



Celluláris neurobiológia

  • Munkatársak
  • Publikációk
  • Elnyert pályázatok
  • Galériák


Prof. Dr. Sík Attila egyetemi tanár


K.Basu, D.Lajoie, T.Aumentado-Armstrong, J.Chen, R.I.Koning, B.Bossy, M.Bostina, A.Sík, E.Bossy-Wetzel, I.Rouiller (2017) Molecular mechanism of DRP1 assembly studied in vitro by cryo-electron microscopy Plos One  DOI: 10.1371/journal.pone.0179397  


J.Crowcombe, S.Dhillon, R.Hurst, F.Muller, S.Egginton,  A.Sik* and E.Tarte (2016): 3D finite element electrical model of larval zebrafish ECG signals Plos One DOI: 10.1371/journal.pone.0165655; * co-corresponding author


A.Tóth, E.Kátai, F.Gallyas, E.Kálmán, P.Bogner, A.Schwarcz, T.Dóczi, A.Sík and J.Pál (2016): In vivo detection of hyperacute neuronal recovery following electric trauma by MRI in rats J. Magnetic Resonance Imaging 44(4):814-22


K.Zeng, J.Yan, Y.Wang, A.Sík, and G. Ouyang, X. Li (2015): Automatic detection of absence seizures with compressive sensing EEG, Neurocomputing 171:497-502


J.Yan, Y.Wang, T.Yu, Y.Li, A.Sík, and X.Li  (2015): Analysis of electrocorticogram in epilepsy patients in term of criticality, Nonlinear Dynamics 83: 1909-1917


A.S. Ferecskó, P.Jiruska, L.Foss, A.D.Powell, W-C.Chang, A.Sík* and J.G.R.Jefferys (2015) Structural and functional substrates of tetanus toxin action in animal model of epilepsy Brain structure and function 220(2):1013-29; * co-corresponding author


A.Magony and A.Sík (2014) Development of a miniature microdrive recording system for multisite multichannel recording from rodent brain OA Neurosciences London, 2(1):4, p1-5


K.Kovács, K.Basu, I.Rouiller, and A.Sík (2013): Regional differences in the expression of K+-Cl– 2 cotransporter in the developing rat neocortex, Brain structure and function, doi: 10.1007/s00429-013-0515-9


S.Gharanei, M.Zatyka, D.Astuti, J.Fenton, E.M Rabai, A.Sík, Z.Nagy and T.G.Barrett (2013) Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its stability and expression Human Molecular Genetics, 22(2):203-17


S.S.Dhillon, E.Doro, I.Magyary, S.Egginton,  A.Sík* and F.Müller (2013) Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs Plos One, * co-corresponding author; 8(4):e60552


Y.Shinohara, A.Hosoya, K.Yahagi, A.S.Ferecskó, K.Yaguchi, A.Sík, M.Itakura, M.Takahashi, and H. Hirase (2012) Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents E.J.Neurosci. 35(5):702-10


R.Blanch, Z.Ahmed, A.Sík, D.Snead, P.Good, M.Berry, R.Scott, and A.Logan (2012) Neuroretinal cell death in a murine model of closed globe injury; pathological and functional characterization Investigative Ophthalmology & Visual Science, 53(11):7220-6


J.Vinet, P. Lemieux, A.Tamburri, P.Tiesinga, V.Gallo and A.Sík (2010): Different subclasses of oligodendrocytes populate mice adult hippocampus E. J. Neurosci.(31)425-38


X. Li,  G.X. Ouyang, A.Usami, Y. Ikegaya and A.Sík (2010) Scale-free power-law distribution characterises functional neuronal assemblies of the hippocampal CA3  network. Biophysical Journal 98(9)1733-41


D.Kroeger, A.Tamburri, F.Amzica and A.Sík (2010) Activity dependent layer-specific changes in the extracellular chloride concentration and chloride driving force in the rat hippocampus J.Neurophysiology 103: 1905-1914


B.Pary, A.Côté, V.Gallo, P.De Koninck and A.Sík (2010) Functional coupling between astrocytes and oligodendrocytes via gap junctions in culture  Neuroscience 167(4): 1032-1043


J.Boucher , H.Kroger  and A.Sík (2010) Realistic modeling of receptor activation in hippocampal excitatory synapses: analysis of multivesicular release, release location, temperature and synaptic crosstalk  Brain structure and function; 215(1):49-65


K. Kovács, A.Sík, C. Ricketts and I.Timofeev (2009) Subcellular distribution of low-voltage activated T-type Ca2+ channel subunits (Cav3.1 and Cav3.3) in reticular thalamic neurons of the cat J. Nerosci.Res. 88(2):448-460


C. Capaday, C. Ethier, L. Brizzi L, A.Sík, C. van Vreeswijk, and D. Gingras (2009) On the Nature of the Intrinsic Connectivity of the Cat Motor Cortex: evidence for a recurrent neural network topology J. Neurophysiol. 102: 2131-2141


K.Basu, C.Gravel, R.Tomioka, T.Kaneko, N.Tamamaki and A.Sík (2008): Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice J. Neuroscience Methods, 170(2):212-9


S. Tétrault, O. Chever, A.Sík * and F. Amzica (2008): Opening of the blood-brain barrier during isoflurane anesthesia Eur. J. Neuroscience, 28:1330-1341; * co-corresponding author


M.Hajós, AA.Kelly, T.Sharp, G.Charette, A.Sík and B.Kocsis (2007): Stereotyped burst activity in a subset of neurochemically identified raphe 5-HT neurons in anaesthetized rats E.J.Neuroscience, 25(1):119-126


M.Derchansky, S.S.Jahromi, M.Mamani,D.S. Shin, A.Sík and  P.L.Carlen (2007): Transition to seizures in the isolated immature hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation J.Physiology, 586(2):477-94


M.Urushitani, A.Sík, T.Sakurai, N.Nukina, R.Takahashi and J.P.Julien (2006): Chromogranin-mediated secretion of ALS-linked superoxide dismutase mutants: a novel pathway to inflammation and motor neuron death Nature Neurosci., 9(1):108-18


B.Kocsis, V.Varga,  L.Dahan and A.Sík (2006): Serotonergic neuron diversity: identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm Proc.Natl.Acad.Sci. USA, 103(4):1059-64


A.Sík, A.Coté and Zs. Boldogkői (2006): Selective spread of neurotropic herpes viruses in the rat hippocampus J. Comparative Neurology, 496(2):229-43.


L.Davidovic, E.Bechara, M.Gravell, XH.Jaglin, S.Tremblay, A.Sík, B.Bardoni and EW. Khandjian  (2006) The nuclear MicroSpherule Protein 58 is a novel RNA-binding protein that interacts with Fragile X Mental Retardation Protein in polyribosomal mRNPs from neurons Human Molecular Genetics, 15(9):1525-38


J.Vinet and A.Sík (2006): Expression pattern of voltage-dependent calcium channel subunits in hippocampal inhibitory neurons in mice Neuroscience, 143(1):189-212


M. Saint-Pierre, M.Tremblay, A.Sík and F. Cicchetti (2006): Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats J. Neurochemistry, 98(3):760-772


M.Levesque, MJ.Wallman, A.Sík* and A. Parent (2006): Neurokinin-1 and neurokinin-3 receptors in the primate substantia nigra, Neuroscience Research, 57(3):362-71, * co-corresponding author


A.Hudmon, E.LeBel, H.Roy, A.Sík, H.Schulman, M.Waxham and P. De Koninck (2005) A Mechanism for CaMKII Clustering at Synaptic and Non-Synaptic Sites Based on Self-Association J.Neurosci. 25(30)6971-83


S.Li, V.Varga, A.Sík and B.Kocsis (2005) GABAergic control of the ascending serotonergic input to the limbic system J.Neurophysiol, 94:2561-2574


N.Kamasawa, A.Sík, M.Morita, T.Yasumura, K.G.V.Davidson, J.I.Nagy and J.E.Rash (2005) Ultrastructural demonstration of connexin-47 and connexin-32 in gap junctions on oligodendrocyte somata, myelin, Schmidt-Lanterman incisures and paranodal loops in rodent CNS Neuroscience 136(1):65-86


E.Timofeeva, C. Dufresne, A.Sík, Z.W. Zhang, and M. Deschênes (2005) Cholinergic modulation of vibrissal receptive fields in trigeminal nuclei J. Neurosci. 25(40):9135-43.


A.Sík, BJ.Passer, EV.Koonin and L.Pellegrini (2004) Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields P-beta, a nuclear-targeted peptide. J.Biol.Chem. 279(15):15323-9


Zs.Boldogköi, A.Sík, Á.Dénes, A.Reichart, J.Toldi, I.Gerendai, K.Kovács and M.Palkovits (2004) Novel tracing paradigms – genetically engineered herpesviruses as tools for mapping functional circuits within the CNS: present status and future prospects. Progress in Neurobiology 72(6):417-45.


J.A.M.Coull, D.Boudreau, K.Bachand, S.A.Prescott, F.Nault, A.Sík, P.De Koninck and Y. De Koninck (2003) Transsynaptic shift in anionic gradient in spinal lamina I neurons as a novel mechanism of a painful peripheral neuropathy. Nature  424(6951):938-42


A.Gulácsi, C.R.Lee, A.Sík, T.Viitanen, K.Kaila, J.M.Tepper and T.F.Freund (2003) Cell type specific differences in the chloride regulatory mechanisms and GABAa receptor mediated inhibition in rat substantia nigra. J.Neurosci. 23(23):8237-46.


V.Varga, A.Sík, T.F.Freund and B.Kocsis (2002) GABAB receptors in the median raphe nucleus: distribution and role in the serotonergic control of hippocampal activity.  Neuroscience, 109(1):112-132


C.Varga, A.Sík, P.Lavallée and M.Deschênes (2002) Dendroarchitecture of relay cells in thalamic barreloids: a substrate for cross-whisker modulation. J.Neurosci. 22(14):6186-94.


Zs.Boldogköi, A.Reichart, I.Tóth, A.Sík, F.Erdélyi, I.Medveczky, C.Llorens-Cortes, M.Palkovits and Zs.Lenkei (2002) Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry. Mol. Brain Res. 109(1-2):103-116


A.I. Gulyás, A.Sík, J.A.Payne, K.Kaila and T.F.Freund (2001) The K+/Cl- cotransporter (KCC2) is preferentially associated with sites of excitatory synaptic transmission in the developing and adult rat hippocampus. Eur.J.Neurosci., 13(12): 2205-2217


A.Sík, A.Gulácsi, Y.Lai, W.K.Doyle, S.Pacia, I.Mody and T.F.Freund (2000) Localization of the A kinase anchoring protein AKAP79 in the human hippocampus. Eur.J.Neurosci., 12(4):1155-1164


A.Sík, R. L.Smith, and T.F.Freund (2000) Distribution of chloride channel-2 immunoreactive neuronal and astrocytic processes in the hippocampus. Neuroscience, 101(1): 51-65


I.Katona, B.Sperlagh, A.Sík, A.Kofalvi, S.E.Vizi and T.F.Freund (1999) Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J.Neurosci., 19(11):4544-4558


Z.Boldogkoi, F.Erdelyi, A.Sík, T.F.Freund and I.Fodor (1999) Construction of a recombinant herpesvirus expressing the jellyfish green fluorescent protein. Luminescence, 14(2):69-74


G.Pyapali, A.Sík, M.Penttonen, G.Buzsaki and D.Turner (1998) Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: Intracellular staining in vivo and in vitro. J.Comp. Neurology, 391(3):335-52


A.Sík, N.Hájos, A.Gulácsi, I.Mody and T.F.Freund (1998) The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. Proc.Natl.Acad.Sci. USA, 95(6):3245-3250


L.Acsady, A.Kamondi, A.Sík, T.F.Freund and G.Buzsaki (1998) GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus. J.Neurosci., 18(9):3386-3403


A.Sík, M.Penttonen and G. Buzsaki (1997) Interneurons in the dentate gyrus: An in vivo intracellular study. Eur.J.Neurosci., 9(3):573-588


M.Penttonen, A.Kamondi, A.Sík, L.Acsady and G.Buzsaki (1997) Feed-forward and feed-back activation of the dentate gyrus in vivo during dentate EEG spikes and sharp wave bursts. Hippocampus, 7(4):437-450


A.Ylinen, A.Bragin, Z.Nadasdy, G.Jando, I.Szabo, A.Sík and G.Buzsaki (1995) Sharp wave-associated high frequency oscillation (200Hz) in the intact hippocampus: network and intracellular mechanism. J.Neurosci., 15(1 Pt 1):30-46


A.Ylinen, I.Soltesz, A. Bragin, M. Penttonen, A.Sík and G. Buzsaki (1995) Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cells.  Hippocampus, 5(1):78-90


A.Sík, M.Penttonen, A. Ylinen and G. Buzsaki (1995) Hippocampal CA1 interneurons: An in vivo intracellular labeling study. J.Neurosci., 15(10):6651-6665


I.Nagy, A.Sík, E.Polgar, M.Petko and M.Antal (1994) Combination of cobalt labeling with immunocythochemical reactions for electron microscopy investigations on the frog spinal cord. Microscopy Research and Technique, 28(1):60-66


M.G.Lee, J.J.Chrobak, A.Sík, R.G.Wiley and G.Buzsaki (1994) Hippocampal theta activity following selective lesion of the septal cholinergic system. Neuroscience, 62(4):1033-1047


A.Sík, A. Ylinen, M. Penttonen and G. Buzsaki (1994) Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science, 265(5179):1772-177


A.Sík, N.Tamamaki and T.F.Freund (1993) Complete axon arborization of single CA3 pyramidal cell in the hippocampus, with special reference to the distribution of postsynaptic parvalbumin-containing interneurons. Eur.J.Neurosci., 5(12):1719-1728


A.I.Gulyas, R.Miles, A.Sík, K.Toth and T.F.Freund (1993) Hippocampal pyramidal neurons excite nonpyramidal cells via single release sites.  Nature, 366(6456):683-687




A.Sík (2016) Creativity in cross-domain collaborations: searching for factors to increase efficiency, Management Research Review 39(2):144-166


Books and book chapters


A.Sík (2006): Merging structure and function: Combination of in vivo extracellular and intracellular electrophysiological recordings with neuroanatomical techniques. In: Neuroanatomical tract-tracing 3: molecules-neurons-systems (Eds.: Zaborszky, Wouterlood, and Lanciego); Springer, New York, USA


G.Buzsaki, A.Bragin, J.J.Chrobak, Z.Nadasdy, A.Sík, M.Hsu and A.Ylinen (1994) Oscillatory and intermittent synchrony in the hippocampus: relevance to memory trace formation. Temporal coding in the brain, Springer, 145-173


M.Hsu, A.Sík, F.Gallyas, Zs.Horvath and G.Buzsaki (1994) Short- term and long-term changes in the postischemic hippocampus. In: Hormonal Restructuring of the Adult Brain, The New York Acad. Sci., (743)121-140


2016-2019 Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real time in intact nervous system by 4D Raman spectroscopy, Horizon 2020, €4.27M

2017-2021 Transcribing the processes of life: Visual Genetics, H2020 Marie Sklodowska-Curie Research and Innovation Staff Exchange, €1.29M, PI

2014-2017 Midbrain dopamine systems and control of bladder function, MRC, £530,960 co-PI; (Lovick, Sik)


Past funding:

2014-2016 Functional and structural changes of brain circuitry in altered oxygen conditions, European Council, Marie Curie Fellowship, £309,000, PI

2013-2016 Novel computational neuronal oscillation to elucidate pathological brain state, Royal Society, International Exchanges NSFC (China) £12,000, PI

2012-2016 High throughput electrocardiogram recording of zebrafish embryos, British Heart Foundation, New Horizons Grant, £301,840, PI

2012-2015 Neural mechanisms of memory updating, BBSRC, £515,663, co-PI; (Lee, Sik)

2011-2015 Importance of long-range inhibitory connections in hippocampal network oscillations, MRC, £680,000, PI

2014-2015 High throughput ECG and EEG recording of zebrafish embryo, Market research; Enterprising Birmingham Fund, £13,000, PI

2012-2013 Single cell gene delivery in vivo using magnetic nanoparticles, Royal Society, £6,000, PI

2009-2013 Mechanisms of mesial temporal lobe epilepsy, MRC, co-PI £650,000, co-PI; (Jefferys, Sik)

2006-2010 Facility for electron cryomicroscopy and cryo-electron tomography, Canadian Foundation for Innovation, $8,030,290, Montreal-Quebec co-application; project leader in Quebec, PIs: Bergeron, Sik and 6 others

2006-2011 Role of long range projecting inhibitory neurons in hippocampal network oscillations, Canadian Institutes of Health Research, $586,120, PI 

2006-2010 Organization and function of neuronal networks in the sensory cortex, Human Frontiers Science Program, $1,755,000, PI

2004-2009 Microscopy facility maintenance grant, Canadian Institutes of Health Research, $329,530, co-PI; (4 applicants)

2002-2006 Electronic coupling in the hippocampus, Canadian Institutes of Health Research, $323,415,  PI

2001-2002 Different regulation of chloride homeostasis in dopaminergic and GABAergic neuron in substantia nigra, Fonds de la Recherche en sante du Québec, $15,000, PI

2001-2002 Electronic coupling in epilepsy, Savoy Foundation, $15,000, PI

2001-2003 Functions of voltage sensitive ion channels in synaptic plasticity and in neurodegeneration, Fonds de la Recherche en sante du Québec, $30,000, PI

2001-2005 Fellowship,  Fonds de la Recherche en sante du Québec, $200,000, PI

2000-2002 Cellular and molecular control of brain circuit connectivity, Canadian Foundation for Innovation, $1,860,292, co-PI (4 applicants; share: $650,000)

1997-2001 Distribution and subcellular localization of protein kinases and phosphatases, ETT  Hungary, $70,000, PI

1997-2000 Interneuronal network of the hippocampus, Hungarian National Foundation, $110,000, PI