A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The research group works within the Department of Neurology of the University of Pécs and the Pécs Diagnostic Centre (PDC). The research team, which is highly multidisciplinary (physicists, computer scientists, biologists, psychologists, physicians), tries to map the functions and structure of the human brain, to localise higher-order human brain functions, and to investigate the origin and course of various neurological pathologies (e.g. neurological and psychiatric pathologies) using a high-field 3T MR scanner provided by the PDC. Our research group focuses mainly on
1. Mapping human cognitive function in healthy and diseased populations
Currently, our research is mainly focused on understanding the neurobehavioral background of mental fatigue. Perhaps the most important unanswered question about acute and chronic mental fatigue is: why do we get tired? Neither psychological theories nor biological models that attribute the causes to changes in brain oxygenation or energy balance can provide an answer. Our aim is to investigate the functional and structural neural basis of mental fatigue.
2. Understanding the cognitive-neural background of brain reward system disorders (e.g. obesity, internet addiction)
Internet addiction (e.g. social media addiction, smartphone addiction) is a major social problem today. Our aim is to investigate the neural consequences of these 'modern' forms of addiction. In addition, we want to explore the non-specific neural features that are present in both traditional substance addictions and Internet addictions.
3. To study the neural background of neurological pathologies and symptoms (long COPD, epilepsy, multiple sclerosis, Parkinson's disease).
Our research group is primarily looking for biomarkers and neural changes that can help diagnose and better understand neurological disorders.
Perlaki, G., Darnai, G., Arató, Á., Alhour, H.A., Szente, A., Áfra, E., Nagy, S.A., Horváth, R., Kovács, N., Dóczi, T., Orsi, G. (2024) Gray Matter Changes Following Mild COVID‐19: An MR Morphometric Study in Healthy Young People. Journal of Magnetic Resonance Imaging 59: 2152-2161.
Darnai, G., Matuz, A., Alhour, H.A., Perlaki, G., Orsi, G., Arató, Á., Szente, A., Áfra, E., Nagy, S.A., Janszky, J., Csathó, Á. (2023) The neural correlates of mental fatigue and reward processing: A task-based fMRI study. NeuroImage 265: 119812.
Rozgonyi R, Dombi I, Janszky J, Kovács N, Faludi B. Low test-retest reliability of the Epworth Sleepiness Scale within a substantial short time frame. J Sleep Res. 2021 Jan 25:e13277.
Tarkanyi G, Karadi ZN, Szabo Z, Szegedi I, Csiba L, Szapary L. Relationship between leukocyte counts and large vessel occlusion in acute ischemic stroke. BMC Neurol. 2020 Dec 4;20(1):440.
Tényi D, Szűcs A, Kovács N, Illés Z, Janszky J. Paraneoplastic anti-NMDA receptor encephalitis in 1830? Neurol Neuroimmunol Neuroinflamm. 2020 Sep 25;7(6):e887.
Pintér D, Juhász A, Harmat M, Janszky J, Kovács N. The Impact of Trimetazidine on Disease Severity and Quality of Life in Parkinson's Disease. Sci Rep. 2020 Jun 22;10(1):10050.
Pintér D, Janszky J, Kovács N. Minimal Clinically Important Differences for Burke-Fahn-Marsden Dystonia Rating Scale and 36-Item Short-Form Health Survey. Mov Disord. 2020 Jul;35(7):1218-1223.
Toth, M., Papp, K.S., Gede, N., Farkas, K., Kovacs, S., Isnard, J., Hagiwara, K., Gyimesi, C., Kuperczko, D., Doczi, T., Janszky, J. (2019) Surgical outcomes related to invasive EEG monitoring with subdural grids or depth electrodes in adults: a systematic review and meta-analysis. Seizure 70: 12-19.
Darnai, G., Perlaki, G., Zsidó, A.N., Inhóf, O., Orsi, G., Horváth, R., Nagy, S.A., Lábadi, B., Tényi, D., Kovács, N., Dóczi, T. (2019) Internet addiction and functional brain networks: task-related fMRI study. Scientific Reports 9: 15777.
Pintér D, Makkos A, Kovács M, Janszky J, Kovács N. Minimal clinically important difference for the quality of life in essential tremor questionnaire. Mov Disord. 2019 May;34(5):759-760.
Makkos A, Kovács M, Aschermann Z, Harmat M, Janszky J, Karádi K, Kovács N. Are the MDS-UPDRS-Based Composite Scores Clinically Applicable? Mov Disord. 2018 May;33(5):835-839.
Horváth K, Aschermann Z, Kovács M, Makkos A, Harmat M, Janszky J, Komoly S, Karádi K, Kovács N. Minimal clinically important differences for the experiences of daily living parts of movement disorder society-sponsored unified Parkinson's disease rating scale. Mov Disord. 2017 May;32(5):789-793.
Tényi D, Gyimesi C, Kupó P, Horváth R, Bóné B, Barsi P, Kovács N, Simor T, Siegler Z, Környei L, Fogarasi A, Janszky J. Ictal asystole: A systematic review. Epilepsia. 2017 Mar;58(3):356-362.
Tényi D, Gyimesi C, Horváth R, Kovács N, Ábrahám H, Darnai G, Fogarasi A, Büki A, Janszky J. Concussive convulsions: A YouTube video analysis. Epilepsia. 2016 Aug;57(8):1310-6.
Pal E, Nagy F, Aschermann Z, Balazs E, Kovacs N. The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease: a randomized, double-blind, placebo-controlled study. Mov Disord. 2010 Oct 30;25(14):2311-7.
Toth V, Hejjel L, Fogarasi A, Gyimesi C, Orsi G, Szucs A, Kovacs N, Komoly S, Ebner A, Janszky J. Periictal heart rate variability analysis suggests long-term postictal autonomic disturbance in epilepsy. Eur J Neurol. 2010 Jun 1;17(6):780-7.
Auer T, Pinter S, Kovacs N, Kalmar Z, Nagy F, Horvath RA, Koszo B, Kotek G, Perlaki G, Koves M, Kalman B, Komoly S, Schwarcz A, Woermann FG, Janszky J. Does obstetric brachial plexus injury influence speech dominance? Ann Neurol. 2009 Jan;65(1):57-66.
Auer T, Barsi P, Bone B, Angyalosi A, Aradi M, Szalay C, Horvath RA, Kovacs N, Kotek G, Fogarasi A, Komoly S, Janszky I, Schwarcz A, Janszky J. History of simple febrile seizures is associated with hippocampal abnormalities in adults. Epilepsia. 2008 Sep;49(9):1562-9.
Kovacs N, Balas I, Illes Z, Kellenyi L, Doczi TP, Czopf J, Poto L, Nagy F. Uniform qualitative electrophysiological changes in postoperative rest tremor. Mov Disord. 2006 Mar;21(3):318-24. doi: 10.1002/mds.20712. PMID: 16211617.
