A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
Studying stress-induced structural and functional alterations in animal models for neuropsychiatric disorders
The physiological stress response is essential for our daily survival and helps us to adapt to the ever changing environment. However, sustained uncontrollable stress can induce various dysfunctions and pathological alterations in our body. Our key interest is the structural plasticity of the brain in relation to stress.
We focus on stress-induced changes in neuronal plasticity affecting neuronal networks, adult neurogenesis as well as glial changes in the hippocampus and neocortex. We hypothesize that such stress-induced structural changes contribute to the pathophysiology of psychiatric disorders like depression or schizophrenia, but medications like antidepressant, antipsychotic treatment can also have influence.
We aim for translational research using multidisciplinary methods ranging from molecular biology to in vitro and in vivo imaging.
Czéh B, Fuchs E, Wiborg O, Simon M (2015) Animal models of major depression and their clinical implications. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 17. pii: S0278-5846(15)00070-6. doi: 10.1016/j.pnpbp.2015.04.004. [Epub ahead of print] Invited review.
http://www.sciencedirect.com/science/article/pii/S0278584615000706
Czéh B, Varga ZK, Henningsen K, Kovács GL, Miseta A, Wiborg O (2015) Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences. Hippocampus. 2015 Mar;25(3):393-405. doi: 10.1002/hipo.22382.
http://onlinelibrary.wiley.com/doi/10.1002/hipo.22382/abstract;jsessionid=CCF6AD6F5E3DC03C1039D1EAA588A420.f04t01
Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B (2014) Neuropathology of stress. Acta Neuropathol. 2014 Jan;127(1):109-35. doi: 10.1007/s00401-013-1223-5. Invited review.
http://link.springer.com/article/10.1007%2Fs00401-013-1223-5
National Brain Research Program (NAP-B)
http://www.agykutatas.com/
Analysis of neurobiological changes related to depressive disorders in an animal model based on chronic behavioral stress and also clinal samples. We use of in vivo and post mortem imaging, and laboratory diagnostic tools searching for potential biomarkers.
MicroBrightField System (StereoInvestigator and Neurolucida) for post mortem quantitative histopathologica analysis. Nikon Eclipse Ti-U fluorescent microscope. Beckman CEQ 8000 genetic analysis system / DNA sequencer, QIA Cube for fully automated purification of DNA, RNA, or proteins, Liquid chromatography tandem mass spectrometry (LC/MS/MS), electrophoreses/blotting.
