A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The primary interest of our research group is to understand the neurobiological background of neuropsychiatric disorders. In collaboration with other group, we investigate the neurobiological background of major depressive disorder, Alzheimer’s disease, sclerosis multiplex and epilepsy. We work with animal models with high translational value and perform clinical studies. In collaboration with the Pécs Diagnostic Centre, we employ and develop neuroimaging methods to detect structural and functional changes that are characteristic to disease. We use quantitative light- and electron microscopy methods to detect cellular changes in the brain of human patients and experimental animals. We also perform in vivo and in vitro electrophysiological studies using transgenic mice to investigate the functional neuroanatomy of the entorhinal cortex. We also use molecular methods to reveal potential biomarkers that could help the diagnosis.
Currently, we are particularly interested in the long-term consequences of early life events. We use various magnetic resonance imaging methods in combination with psychological tests to study the impact of adverse childhood experiences on brain development and function.
Gálber M, Nagy SA, Orsi G, Perlaki G, Simon M, Czéh B. (2024) Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity. NeuroImage: Clinical, 43, 103632. DOI: 10.1016/j.nicl.2024.103632
Geiger L, Orsi G, Cseh T, Gombos K, Illés Z, Czéh B. (2023) Circulating microRNAs correlate with structural and functional MRI parameters in patients with multiple sclerosis. Frontiers in Molecular Neuroscience, 16, 1173212. DOI: 10.3389/fnmol.2023.1173212
Borbély É, Simon M, Fuchs E, Wiborg O, Czéh B, Helyes Z. (2022) Novel drug developmental strategies for treatment-resistant depression. British Journal of Pharmacology, 179(6), 1146–1186. DOI: 10.1111/bph.15753
Szocs S, Henn-Mike N, Agocs-Laboda A, Szabo-Meleg E, Varga C. (2022) Neurogliaform cells mediate feedback inhibition in the medial entorhinal cortex. Frontiers in Neuroanatomy, 16, 779390. DOI: 10.3389/fnana.2022.779390
Nagy SA, Kürtös Z, Németh N, Perlaki G, Csernela E, Lakner FE, Dóczi T, Czéh B, Simon M. (2021) Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task. Neurobiology of Stress, 15, 100399. DOI: 10.1016/j.ynstr.2021.100399
Czéh B, Simon M. (2021) Benefits of animal models to understand the pathophysiology of depressive disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 106, 110049. DOI: 10.1016/j.pnpbp.2020.110049
Kecskés M, Henn-Mike N, Agócs-Laboda Á, Szőcs S, Petykó Z, Varga C. (2020) Somatostatin expressing GABAergic interneurons in the medial entorhinal cortex preferentially inhibit layer III-V pyramidal cells. Communications Biology, 3(1), 754. DOI: 10.1038/s42003-020-01496-x
Nagy SA, Vranesics A, Varga Z, Csabai D, Bruszt N, Bali ZK, Perlaki G, Hernádi I, Berente Z, Miseta A, Dóczi T, Czéh B. (2020) Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A Longitudinal in vivo Diffusion Tensor Imaging Study. Frontiers in Neuroscience, 14, 474. DOI: 10.3389/fnins.2020.00474
Czéh B, Fuchs E, Wiborg O, Simon M (2015) Animal models of major depression and their clinical implications. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 17. pii: S0278-5846(15)00070-6. doi: 10.1016/j.pnpbp.2015.04.004. [Epub ahead of print] Invited review. http://www.sciencedirect.com/science/article/pii/S0278584615000706
Czéh B, Varga ZK, Henningsen K, Kovács GL, Miseta A, Wiborg O (2015) Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences. Hippocampus. 2015 Mar;25(3):393-405. doi: 10.1002/hipo.22382. http://onlinelibrary.wiley.com/doi/10.1002/hipo.22382/abstract;jsessionid=CCF6AD6F5E3DC03C1039D1EAA588A420.f04t01
Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B (2014) Neuropathology of stress. Acta Neuropathol. 2014 Jan;127(1):109-35. doi: 10.1007/s00401-013-1223-5. Invited review. http://link.springer.com/article/10.1007%2Fs00401-013-1223-5
National Brain Research Program (NAP-B)
http://www.agykutatas.com/
Analysis of neurobiological changes related to depressive disorders in an animal model based on chronic behavioral stress and also clinal samples. We use of in vivo and post mortem imaging, and laboratory diagnostic tools searching for potential biomarkers.
MicroBrightField System (StereoInvestigator and Neurolucida) for post mortem quantitative histopathologica analysis. Nikon Eclipse Ti-U fluorescent microscope. Beckman CEQ 8000 genetic analysis system / DNA sequencer, QIA Cube for fully automated purification of DNA, RNA, or proteins, Liquid chromatography tandem mass spectrometry (LC/MS/MS), electrophoreses/blotting.
