A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The objective of our research group is to gain insight into the intricate interactions between the developing embryo or fetus and the maternal immune system. Paternal antigens expressed by the fetus are typically recognized as foreign and should be rejected by maternal immune cells. However, during normal gestation, the conceptus is not attacked because the maternal immune system undergoes a reprogramming event that enables it to tolerate these antigens, thereby creating a favorable environment supportive of the developing fetus.
The development of immune tolerance is dependent on the presence of progesterone and its downstream mediator, the progesterone-induced blocking factor (PIBF). The role of PIBF in decidualization, implantation, and ongoing pregnancy has been investigated using PIBF-deficient mice. Our research has demonstrated that embryo-derived extracellular vesicles facilitate feto-maternal communication.
Another pivotal objective of our research is to identify the competent embryo, which is crucial for successful implantation. In the context of assisted reproduction, the objective is to achieve a single pregnancy through the effective transfer of a single embryo. To this end, we have developed a non-invasive test for identifying the competent embryo using flow cytometric determination of DNA-containing extracellular vesicles in embryo culture media.
Furthermore, our research encompasses the development of novel bioinformatics algorithms and data analysis processes, in collaboration with industrial partners, to address challenges in medical biology. We offer professional biostatistical and bioinformatical data analysis services to research groups in Hungary and abroad.
The impact of vitamin D on oocyte and embryo development, as well as its role in maintaining the immunological balance during pregnancy, is currently under investigation. Furthermore, we are developing a mouse model of preeclampsia to enhance our comprehension of this condition and facilitate more effective management strategies.
Furthermore, we are examining uterine progesterone levels in a mouse model after progesterone administration, aiming to determine the concentration of progesterone in the endometrium post-administration.
Ahmadi, H., Soltani-Zangbar, MS., Yousefi, M., Baradaran, B., Bromand, S., Aghebati-Maleki, Leili., Szekeres-Bartho, J. (2024) The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss. Immunology Letters 266: 106837. PMID: 38266686 DOI: 10.1016/j.imlet.2024.106837
Bognar, Z., Csabai-Tanics, TJ., Gorgey, E., Miko, E., Horvath-Szalai, Z., Szekeres-Bartho, J. (2023) The effect of calcitriol on the development and implantation capacity of embryos from hyper-stimulated mice. Frontiers in Immunology 14: 1200704. PMID: 37545525 DOI: 10.3389/fimmu.2023.1200704
Raghupathy, R., Szekeres-Bartho, J. (2022) Progesterone: A Unique Hormone with Immunomodulatory Roles in Pregnancy. International Journal of Molecular Sciences 23: 1333. PMID: 35163255 DOI: 10.3390/ijms23031333
Piccinni, MP., Raghupathy, R., Saito, S., Szekeres-Bartho, J. (2021) Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction. Frontiers in Immunology 12: 717808. PMID: 34394125 DOI: 10.3389/fimmu.2021.717808
Csabai, T., Pallinger, E., Kovacs, AF., Miko, E., Bognar, Z., Szekeres-Bartho, J. (2020) Altered Immune Response and Implantation Failure in Progesterone-Induced Blocking Factor-Deficient Mice. Frontiers in Immunology 11: 349. PMID: 32218780 DOI: 10.3389/fimmu.2020.00349