A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The principal objective of the research group is to develop highly efficient synthetic methodologies that can be employed for the synthesis of compounds with significant practical applications, including those in the pharmaceutical, photocatalytic and environmental domains. The research encompasses the development of environmentally benign ("low-waste") synthetic procedures, complemented by related analytical investigations. Notable research areas and topics include the activation of built-in small molecules, such as carbon monoxide, and related aspects, into skeletons and building blocks via homogeneous catalytic reactions. Further investigation has elucidated the reaction mechanism through analytical and theoretical methods. Additionally, the synthesis and application of paramagnetic building blocks (nitroxides) have been employed in research projects of pharmaceutical and biophysical interest. Furthermore, the investigation of weak chemical interactions, developments in the field of sensor chemistry, and the synthesis of 'host' compounds and their use in supramolecular chemistry have been undertaken. Finally, the investigation of alternative solvents, such as biomass-based solvents, in syntheses has been conducted.
In addition to the aforementioned research activities, the laboratory offers a range of services to support academic and industrial partnerships. These include NMR measurements, inert, microwave irradiation and high-pressure experiments at the laboratory level, as well as investigations based on fluorescence or Rayleigh-scattering measurements. Other professional services include the measurement of polarization, anisotropy, and solvent relaxation (Fluorolog tau3 fluorimeter), as well as investigations based on Raman scattering (scanning Raman photometer, atomic force microscopy). Lastly, the following highly intricate instruments are used to provide services: GC-MS measurements, microcalorimetry measurements, and conformation analysis of proteins (SETARAM).
Recent publications of the Green Chemistry Research Group
Marnautov, N.A., Matveev, M.V., Gulin, A.A., Kálai, T., Bognár, B., Rebrikova, A.T., Chumakova, N.A. (2024) Orientational Ordering of Graphene Oxide Membranes by a Spin Probe Technique and SEM Image Analysis. Physical Chemistry 128: 2543-2550 https://doi.org/10.1021/acs.jpcc.3c07127
P. Szuroczki, A. Takátsy, Z. Csók, T. R.Kégl, L. Kollár: Unexpected Selectivities in Transition Metal-Catalyzed Hydroformylation of Vinyl-Substituted Cavitands. MOLECULAR CATALYSIS 535 Paper: 112837 , 5 p. (2023) https://doi.org/10.1016/j.mcat.2022.112837 (4.6, Q2)
L. Kiss, Z. Nagymihály, P. Szabó, L. Kollár, S. Kunsági-Máté: Detection of residual 2-phenylphenol on lemon rind by electrochemically deposited poly(hydroxybenzaldehydes) and poly(hydroxybenzoic acids) films. MATERIALS 16 : 1 Paper: 357 , 12 p. (2023) https://doi.org/10.3390/ma16010357 (3.4,Q2)
N. Uzunlu, P. Pongrácz, L. Kollár, A. Takács: Alkyl Levulinates and 2-Methyltetrahydrofuran: Possible Biomass-Based Solvents in Palladium-Catalysed Aminocarbonylation. MOLECULES 28 : 1 Paper: 442, 15 p.(2023) https://doi.org/10.3390/molecules28010442 (4.6,Q1)
L. Kiss, Z. Nagymihály, L. Kollár, S. Kunsági-Máté: Voltammetric and fluorimeric studies of dibenzoylmethane on glassy carbon electrode and its interaction with tetrakis(3,5-dicarboxyphenoxy)cavitand derivative. MOLECULES 28 : 1 Paper: 185 , 9 p. (2023) https://doi.org/10.3390/molecules28010185 (4.6,Q1)
S. Chniti, L. Kollár, A. Bényei, Á. Dörnyei, A. Takács: Highly chemoselective one-step synthesis of novel N-substituted pyrrolo[3,4-b]quinoline-1,3-dione via palladium-catalysed aminocarbonylation/carbonylative cyclization sequence. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 26 : 10 Paper:me202201374 (2023) https://doi.org/10.1002/ejoc.202201374 (2.8, Q2)
L. Kollár, A.Takács, C. Molnár, A. Kovács, L. T. Mika, P. Pongrácz: Palladium-catalyzed selective amino- and alkoxycarbonylation of iodoarenes with aliphatic aminoalcohols as heterobifunctional O,N-nucleophiles. JOURNAL OF ORGANIC CHEMISTRY 88 : 8 pp. 5172-5179. , 8 p. (2023) https://doi.org/10.1021/acs.joc.2c02712 (3.6, Q1)
F. Bencze, B. Bognár, T. Kálai, L. Kollár, Z. Nagymihály, S. Kunsági-Máté: A new application of spin and fluorescence double sensor molecules. MOLECULES 28 : 7 Paper: 2978 , 12 p. (2023) https://doi.org/10.3390/molecules28072978 (4.6,Q1)
F. Bede, S. Mahó, V. Sándor, G. Mikle, L. Kollár: Carboxamide formation in less favoured positions: facile synthesis of 7-carboxamidochenodeoxycholanic acid derivatives TETRAHEDRON 133 Paper: 133292 , 4 p. (2023) https://doi.org/10.1016/j.tet.2023.133292 (2.1,Q2)
F. Bede, L. Kollár, N. Lambert, P. Huszthy, P. Pongrácz: Palladium-catalysed hydroaminocarbonylation of olefins with aliphatic amines without additives. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 26 : 31 Paper: e202300571 (2023) https://doi.org/10.1002/ejoc.202300571 (2.8,Q2)
Y. Bai, Z. Li, H. Yang, H. Li, S. Kunsági-Máté, H. Yan, S. Yin: Effect of plasma process on hydrogen evolution reaction of ternary MoS2(1−x)Se2x alloys. JOURNAL OF ALLOYS AND COMPOUNDS 934 Paper: 167961 , 35 p. (2023) https://doi.org/10.1016/j.jallcom.2022.167961 (6.2,Q1)
D. Kincses, D. Jordáki, D. Szebeni, S. Kunsági-Máté, J. Szalma, E. Lempel: Effect of Ceramic and Dentin Thicknesses and Type of Resin-Based Luting Agents on Intrapulpal Temperature Changes during Luting of Ceramic Inlays. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 : 6 Paper: 5466 , 17 p. (2023) https://doi.org/10.3390/ijms24065466 (5.6,Q1)
L. Kiss, S. Kunsági-Máté, P. Szabó: Studies of Phenol Electrooxidation Performed on Platinum Electrode in Dimethyl Sulphoxide Medium. Determination of Unreacted Phenol by the Effect of 4-vinylbenzenesulphonate on the Electrooxidation Process. ELECTROANALYSIS 35 : 4 Paper: e202200268 , 9 p. (2023) https://doi.org/10.1002/elan.202200268 (3,Q2)
L. Kiss, S. Kunsági-Máté: Scan rate and concentration dependence of the voltammograms of substituted phenols on electrodes with different size, diffusion coefficients of phenols in different solvents. CANADIAN JOURNAL OF CHEMISTRY 101 : 5 pp. 297-305. , 9 p. (2023) https://doi.org/10.1139/cjc-2022-0096 (1.1,Q3)
E. Lempel, D. Szebeni, Zs. Őri, T. Kiss, J. Szalma, BV. Lovász, S. Kunsági-Máté, K. Böddi: The effect of high-irradiance rapid polymerization on degree of conversion, monomer elution, polymerization shrinkage and porosity of bulk-fill resin composites. DENTAL MATERIALS 39 : 4 pp. 442-453. , 12 p. (2023) https://doi.org/10.1016/j.dental.2023.03.016 (5,Q1)
L. Tong, C. Su, H. Li, X. Wang, W. Fan, Q. Wang, S. Kunsági-Máté, H. Yan, S. Yin: Self-Driven Gr/WSe2/Gr Photodetector with High Performance Based on Asymmetric Schottky van der Waals Contacts. ACS APPLIED MATERIALS & INTERFACES 15 : 49 pp. 57868-57878, 11 p. (2023) https://doi.org/10.1021/acsami.3c14331 (9.5,Q1)
H. Yan, M. Zhang, S. Wang, H. Li, S. Kunsági-Máté, S. Yin: Raman spectroscopy of strained monolayer graphene modulated by monodispersed Au nanoparticles. APPLIED SURFACE SCIENCE 610 Paper: 155531 , 10 p. (2023) https://doi.org/10.1016/j.apsusc.2022.155531 (6.7,Q1)
L. K. Muthuri, L. Nagy, G. Nagy: Chemically modified pencil electrodes for application in reagentless chronopotentiometric antioxidant activity measurement. ELECTROANALYSIS 2023;35:e202200505 https://doi.org/10.1002/elan.202200505 (3,Q2)
Z. Meiszterics, A. Kiss, L. Nagy, T. Zsebe, Gy.F. Vasvári, D. C. Csonka, G.Nagy: Investigationof the regenerationof the passive surface oxide layer of TiAl6V4 alloy printe by WAAM technology using different electrochemical test methods. ELECTROANALYSIS 2023;35:e202200506 https://doi.org/10.1002/elan.202200506 (3,Q2)
Selected recent publications of the Green Chemistry Research Group
(Szentágothai Research Centre is indicated in the affiliation)
Total number of publications (between July 2018 and June 2020)
Q1: 37, Q2:24, Q3: 8, Q4: 2
IF (Total): 211.001
P. Szuroczki, G. Mikle, L. Kollár:
Synthesis of oxazol derivatives from iodoalkenes via aminocarbonylation–cycloisomerization sequence in one-pot reaction.
Mol. Catal. 452 (2018) 68-74. ( Q1, IF: 2.938)
A. Abu Seni, L, Kollár, L. T. Mika, P. Pongrácz:
Rhodium-catalysed aryloxycarbonylation of iodo-aromatics by 4-substituted phenols with carbon monoxide or paraformaldehyde.
Mol. Catal. 457 (2018) 67-73. (Q1, IF: 2.938)
E. Sághy, M. Payrits, Z. Helyes, T. Bíró-Sütő, R. Skodáné Földes, E. Szánti-Pintér, J. Erostyák, G. Makkai, G. Sétáló Jr., L. Kollár, T. Kőszegi, R. Csepregi, J. Szolcsányi, E Szőke:
Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by modulation of lipid rafts.
J. Lipid Res. 59 (2018) 1851-1863. (Q1, IF: 4.743)
N. Pálinkás, L. Kollár, T. Kégl:
Palladium-Catalysed Synthesis of Amidines via Isonitrile Insertion.
ACS Omega 3 (2018) 16118−16126. ( Q1, IF: 2.584)
T. R. Kégl,, L. Kollár, T. Kégl:
Computational Characterization of Bidentate P-donor Ligands: Direct Comparision to Tolman’s Electronic Parameters.
Molecules 23 (2018) 3176; doi:10.3390/molecules23123176. (Q1, IF: 3.060)
E. Lempel, Zs. Őri, J. Szalma, B. V. Lovász, A. Kiss, Á. Tóth, S. Kunsági-Máté:
Effect of exposure time and pre-heating on the conversion degree of conventional, bulk-fill, fiber reinforced and polyacid-modified resin composites.
Dental Materials 35 (2019) 217-228. (Q1, IF: 4.440)
S. Das, Z. Gazdag, L. Szente, M. Meggyes, Gy. Horváth, B. Lemli, S. Kunsági-Máté, M. Kuzma, T. Kőszegi:
Antioxidant and antimicrobial properties of randomly methylated β cyclodextrin – captured essential oils.
Food Chemistry 278 (2019) 305-313. (Q1, IF: 5.399)
Z. Faisal, S. Kunsági-Máté, B. Lemli, L. Szente, D. Bergmann, H. Humpf, M. Poór:
Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.
Molecules, 24 (2019) 1328. (Q1, IF: 3.060)
E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Dellafiora, C. Dall’ Asta, G. Cruciani, G. Pethő, M. Poór:
Interaction of Mycotoxin Alternariol with Serum Albumin.
Int. J. Mol. Sci. 20 (2019) 2352. (Q1, IF: 4.153)
B. Lemli, D. Derdák, P. Laczay, D. Kovács, S. Kunsági-Máte:
Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin.
Molecules 23 (2018) 1915-1924. (Q1, IF: 3.06)
V. Mohos, E. Fliszár-Nyúl, G. Schilli,Cs. Hetényi, B. Lemli, S. Kunsági-Máté, B. Bognár, M. Poór:
Interaction of Chrysin and Its Main ConjugatedMetabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide withSerum Albumin.
Int. J. Mol. Sci. 19 (2018) 4073-4087. (Q1, IF: 4.183)
A. Asserghine, D. Filotás, B. Németh, L. Nagy, G. Nagy:
Potentiometric scanning electrochemical microscopy for monitoring the pH distribution during the self-healing of passive titanium dioxide layer on titanium dental root implant exposed to physiological buffered (PBS) medium.
Electrochem. Commun. 95 (2018) 1. (Q1, IF: 4.197)
D. Filotás, B.M. Fernández-Pérez, A. Kiss, L. Nagy, G. Nagy, R.M. Souto:
Multi-barrel electrodes containing an internal micro-reference for the improved visualization of galvanic corrosion processes on magnesium-based materials using potentiometric scanning electrochemical microscopy.
Sensors & Actuators: B. Chemical (Ref. No.: SNB-D-19-00677R2). (Q1, IF: 6.393)
B. Bartal, G. Mikle, L. Kollár, P. Pongrácz:
Palladium-catalysed carbonylations of alkyl and alkenyl halides with formic acid as carbonyl source. Synthesis of α,β-unsaturated carboxylic acids and esters.
Mol. Catal. 467 (2019) 143−149. (Q1, IF: 2.938)
A. Abu Seni, L. Kollár, P. Pongrácz:
Palladium-catalysed intramolecular asymmetric cyclohydroaryloxycarbonylation of 2-allylphenol derivatives. Synthesis of chiral lactones via cyclocarbonylation.
Mol. Catal. 482 (2020) 110673. (IF: 3.687; Q1)
Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:
Solvent switched weak interaction of 4-quinazolinone with a cavitand derivative.
Molecules 25(8) (2020) 1915. (IF: 3.267; Q1))
Z. Preisz, Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:
Weak interaction of the antimetabolite drug methotrexate with a cavitand derivative.
Int. J. Mol. Sci. 21(12) (2020) 4345. (IF: 4.556; Q1)
Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T.:
Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides.
Synthesis 51 (2019) 4463-4472. (IF: 2.675; Q1)
Zsidó, B. Z.; Balog, M.; Erős, N.; Poór, M.; Mohos, V.; Fliszár-Nyúl, E.; Hetényi, Cs.; Masaki, N.; Hideg, K.; Kálai, T.; Bognár, B.:
Synthesis of spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity
Int. J. Mol. Sci. 21 (2019) 508. (IF: 4.556; Q1)
Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T.:
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.
Molecules 25 (2020) 2430. (IF: 3.267; Q1)
Z. Faisal, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
CyclodextrinsCanEntrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer.
Biomolecules 9 (2019) 354-362. (IF: 4.082, Q1)
E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer.
Biomolecules 9 (2019) 428-446. (IF: 4.082, Q1)
Z. Zelma, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
Interaction of zearalenone-14-sulfate with cyclodextrins and theremoval of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer.
J. Mol. Liq. 310 (2020) 113236. (IF: 5.065, Q1)
H. Mohamed Ameen, S. Kunsági-Máté, P. Noveczky, L. Szente, B. Lemli:
Adsorption of Sulfamethazine Drug onto the Modified Derivatives of Carbon Nanotubes at Different pH.
Molecules 25 (2020) 2489-2499. (IF: 3.267, Q1)
H. Yan, S. Lin, R. Zhang, H. Li, B. Fu, J. Liu, L. Liu, S. Kunsági-Máté, Y. An:
Facile synthesis of high-crystalline Bi2Se3 nanoribbons without Se vacancies and their properties.
J. Mat. Sci. 55 (2020) 5145-5155. (IF: 3.553, Q1)
V. Mohos, E. Fliszár-Nyúl, B. Lemli, B. Zsidó, Z. Balázs, Cs. Hetényi, P. Mladěnka, P. Horký, M. Pour, M. Poór:
Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metaboliteswith Human Serum Albumin and Cytochrome P450 Enzymes.
Biomolecules 10 (2020) 409-426. (IF: 4.082; Q1)
A. Asserghine, M. M-Kosanović , L. Nagy, G.Nagy:
In situ monitoring of the transpassivation and repassivation of the passive film on nitinol biomaterial by scanning electrochemical microscopy.
Electrochem. Commun. 107 (2019) 1–4, 106539. (IF: 4.333; Q1)
D. Filotas, B.M. Fernandez-Perez, L. Nagy, G. Nagy, R.M. Souto:
A novel Scanning Electrochemical Microscopy strategy for the investigation of anomalous hydrogen evolution from AZ63 magnesium alloy.
Sensors and Actuators: B. Chemical 308 (2020) 127691. (IF: 7.100; Q1)
A. Asserghine, M. Medvidovic-Kosanovic, L. Nagy, R. M. Souto, G. Nagy:
A study of the electrochemical reactivity of titanium under cathodic polarization by means of combined feedback and redox competition modes of scanning electrochemical microscopy.
Sensors and Actuators B: Chemical, 320 (2020) 128339. (IF: 7.100; Q1)
OTKA K104956: Nitroxidokat és előanyagaikat tartalmazó szenzorok és biomolekulák szintézise (T. Kálai, 18M HUF for 4 years)
OTKA K113177: Homogénkatalitikus aszimmetrikus karbonilezési reakciók és mechanizmus-vizsgálatuk (L. Kollár, 24M HUF for 4 years))
TÉT_12_RO-1-2013-0015: Highly effective voltammetric methods f for monoamine neurotransmitter assessments in complex biological matrices. (1.6 M HUF)
TÉT_12_RO-1-2013-0018: Mapping of Nitro-Oxidative Species by Scanning Electrochemical Microscopy with Micro(bio)sensors. (1.3 M HUF)
TÉT_12_CN-1-2012-0040: Modifying lateral strain in III-nitride-based epitaxial layers by selectively patterning sapphire substrates with CNT bundles and graphene fractions (Xiamen University, China, 9.6 M HUF + 0.3 M CNY)
2019-2.1.11-TÉT-2019-00042 Study on the pharmacological effectiveness of chiral methotrexate molecules surrounded by the chiral water clusters (Austria)
TÁMOP-4.2.2.A-11/1/KONV-2012-0065: Synthesis of supramolecular systems, their investigation and application in sensor chemistry. (170 M HUF) (total: 341M HUF for 2 years), PI: L. Kollár)
Chemical industry, pharmaceutical industry
PhD degrees obtained recently:
( between July 2018 and June 2020; indicated at www.doktori.hu)
PhD Thesis, 2019. (Research adviser: L. Kollár)
PhD Thesis, 2018. (Research adviser: L. Kollár)
PhD Thesis 2018 (Research adviser: T. Kálai)
PhD Thesis, 2018. (Research adviser: L. Nagy, G. Nagy)
PhD Thesis, 2020. (Research adviser: L. Kollár)
PhD Thesis, 2020. (Research adviser: B. Lemli)
PhD Thesis, 2020. (Research advisers: G. Nagy and L. Nagy)
