A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
Preliminaries
The dendrimers are one of the most important nanosize building blocks. Their technological and practical applications are also remarkable. Beside the industrial use of the dendrimers gain wide application also in pharmacology. The efforts aiming at the development of dendrimers, among them our present research, are focused on the synthesis of those ones able to form inclusion derivatives with the target compunds.
The first poly(amido)amidoamine (’PAMAM’) dendrimers were followed by more complicated structures containing further heteroatoms, cross-linkings and graphite-like substructures.
Our target compounds are the so-called host dendrimers which may gain application both in pharmacology and analytical chemistry.
The topics to be investigated
Dr. Tamas Kalai’s research is focused on synthesis and applications of stable nitroxide free radicals including the selective transformations of their functional groups in the presence of the free radical center. Extensive studies of stable nitroxide free radicals first appeared 60 years ago, and their application is rather diverse and extends beyond spin labeling. Stable nitroxide free radicals are used as co-oxidants in organic chemistry, building blocks for magnetic materials, superoxide dismutase mimics, antiproliferative compounds, mediators of polymerization, redox active materials in batteries, and magnetic resonance imaging (MRI) as well as electron paramagnetic resonance imaging (EPRI) contrast agents. These applications demand various scaffolds with diverse substitution patterns on pyrroline and piperidine nitroxides, including condensation with miscellaneous carbocycles and heterocycles. My colleagues and I are committed to fulfill these demands for both ‘in house’ and international cooperators.
Graphical abstracts of some recent selected publications are shown below:
Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides: Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T. Synthesis 2019, 51, 4463-4472.
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates: Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T. Molecules 2020, 25, 2430.
Potential of Isotope Substitution in EPR Studies of Nitroxide Biradicals: Zaripov, R. B.; Khairutdinov, I. T.; Kálai, T.; Kish, K.; Kokorin, A. I.; Salikhov K. M. Applied Magnetic Resonance 2020, 51, 523–543.
Selected recent publications of the Green Chemistry Research Group
(Szentágothai Research Centre is indicated in the affiliation)
Total number of publications (between July 2018 and June 2020)
Q1: 37, Q2:24, Q3: 8, Q4: 2
IF (Total): 211.001
P. Szuroczki, G. Mikle, L. Kollár:
Synthesis of oxazol derivatives from iodoalkenes via aminocarbonylation–cycloisomerization sequence in one-pot reaction.
Mol. Catal. 452 (2018) 68-74. ( Q1, IF: 2.938)
A. Abu Seni, L, Kollár, L. T. Mika, P. Pongrácz:
Rhodium-catalysed aryloxycarbonylation of iodo-aromatics by 4-substituted phenols with carbon monoxide or paraformaldehyde.
Mol. Catal. 457 (2018) 67-73. (Q1, IF: 2.938)
E. Sághy, M. Payrits, Z. Helyes, T. Bíró-Sütő, R. Skodáné Földes, E. Szánti-Pintér, J. Erostyák, G. Makkai, G. Sétáló Jr., L. Kollár, T. Kőszegi, R. Csepregi, J. Szolcsányi, E Szőke:
Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by modulation of lipid rafts.
J. Lipid Res. 59 (2018) 1851-1863. (Q1, IF: 4.743)
N. Pálinkás, L. Kollár, T. Kégl:
Palladium-Catalysed Synthesis of Amidines via Isonitrile Insertion.
ACS Omega 3 (2018) 16118−16126. ( Q1, IF: 2.584)
T. R. Kégl,, L. Kollár, T. Kégl:
Computational Characterization of Bidentate P-donor Ligands: Direct Comparision to Tolman’s Electronic Parameters.
Molecules 23 (2018) 3176; doi:10.3390/molecules23123176. (Q1, IF: 3.060)
E. Lempel, Zs. Őri, J. Szalma, B. V. Lovász, A. Kiss, Á. Tóth, S. Kunsági-Máté:
Effect of exposure time and pre-heating on the conversion degree of conventional, bulk-fill, fiber reinforced and polyacid-modified resin composites.
Dental Materials 35 (2019) 217-228. (Q1, IF: 4.440)
S. Das, Z. Gazdag, L. Szente, M. Meggyes, Gy. Horváth, B. Lemli, S. Kunsági-Máté, M. Kuzma, T. Kőszegi:
Antioxidant and antimicrobial properties of randomly methylated β cyclodextrin – captured essential oils.
Food Chemistry 278 (2019) 305-313. (Q1, IF: 5.399)
Z. Faisal, S. Kunsági-Máté, B. Lemli, L. Szente, D. Bergmann, H. Humpf, M. Poór:
Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.
Molecules, 24 (2019) 1328. (Q1, IF: 3.060)
E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Dellafiora, C. Dall’ Asta, G. Cruciani, G. Pethő, M. Poór:
Interaction of Mycotoxin Alternariol with Serum Albumin.
Int. J. Mol. Sci. 20 (2019) 2352. (Q1, IF: 4.153)
B. Lemli, D. Derdák, P. Laczay, D. Kovács, S. Kunsági-Máte:
Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin.
Molecules 23 (2018) 1915-1924. (Q1, IF: 3.06)
V. Mohos, E. Fliszár-Nyúl, G. Schilli,Cs. Hetényi, B. Lemli, S. Kunsági-Máté, B. Bognár, M. Poór:
Interaction of Chrysin and Its Main ConjugatedMetabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide withSerum Albumin.
Int. J. Mol. Sci. 19 (2018) 4073-4087. (Q1, IF: 4.183)
A. Asserghine, D. Filotás, B. Németh, L. Nagy, G. Nagy:
Potentiometric scanning electrochemical microscopy for monitoring the pH distribution during the self-healing of passive titanium dioxide layer on titanium dental root implant exposed to physiological buffered (PBS) medium.
Electrochem. Commun. 95 (2018) 1. (Q1, IF: 4.197)
D. Filotás, B.M. Fernández-Pérez, A. Kiss, L. Nagy, G. Nagy, R.M. Souto:
Multi-barrel electrodes containing an internal micro-reference for the improved visualization of galvanic corrosion processes on magnesium-based materials using potentiometric scanning electrochemical microscopy.
Sensors & Actuators: B. Chemical (Ref. No.: SNB-D-19-00677R2). (Q1, IF: 6.393)
B. Bartal, G. Mikle, L. Kollár, P. Pongrácz:
Palladium-catalysed carbonylations of alkyl and alkenyl halides with formic acid as carbonyl source. Synthesis of α,β-unsaturated carboxylic acids and esters.
Mol. Catal. 467 (2019) 143−149. (Q1, IF: 2.938)
A. Abu Seni, L. Kollár, P. Pongrácz:
Palladium-catalysed intramolecular asymmetric cyclohydroaryloxycarbonylation of 2-allylphenol derivatives. Synthesis of chiral lactones via cyclocarbonylation.
Mol. Catal. 482 (2020) 110673. (IF: 3.687; Q1)
Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:
Solvent switched weak interaction of 4-quinazolinone with a cavitand derivative.
Molecules 25(8) (2020) 1915. (IF: 3.267; Q1))
Z. Preisz, Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:
Weak interaction of the antimetabolite drug methotrexate with a cavitand derivative.
Int. J. Mol. Sci. 21(12) (2020) 4345. (IF: 4.556; Q1)
Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T.:
Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides.
Synthesis 51 (2019) 4463-4472. (IF: 2.675; Q1)
Zsidó, B. Z.; Balog, M.; Erős, N.; Poór, M.; Mohos, V.; Fliszár-Nyúl, E.; Hetényi, Cs.; Masaki, N.; Hideg, K.; Kálai, T.; Bognár, B.:
Synthesis of spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity
Int. J. Mol. Sci. 21 (2019) 508. (IF: 4.556; Q1)
Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T.:
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.
Molecules 25 (2020) 2430. (IF: 3.267; Q1)
Z. Faisal, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
CyclodextrinsCanEntrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer.
Biomolecules 9 (2019) 354-362. (IF: 4.082, Q1)
E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer.
Biomolecules 9 (2019) 428-446. (IF: 4.082, Q1)
Z. Zelma, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:
Interaction of zearalenone-14-sulfate with cyclodextrins and theremoval of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer.
J. Mol. Liq. 310 (2020) 113236. (IF: 5.065, Q1)
H. Mohamed Ameen, S. Kunsági-Máté, P. Noveczky, L. Szente, B. Lemli:
Adsorption of Sulfamethazine Drug onto the Modified Derivatives of Carbon Nanotubes at Different pH.
Molecules 25 (2020) 2489-2499. (IF: 3.267, Q1)
H. Yan, S. Lin, R. Zhang, H. Li, B. Fu, J. Liu, L. Liu, S. Kunsági-Máté, Y. An:
Facile synthesis of high-crystalline Bi2Se3 nanoribbons without Se vacancies and their properties.
J. Mat. Sci. 55 (2020) 5145-5155. (IF: 3.553, Q1)
V. Mohos, E. Fliszár-Nyúl, B. Lemli, B. Zsidó, Z. Balázs, Cs. Hetényi, P. Mladěnka, P. Horký, M. Pour, M. Poór:
Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metaboliteswith Human Serum Albumin and Cytochrome P450 Enzymes.
Biomolecules 10 (2020) 409-426. (IF: 4.082; Q1)
A. Asserghine, M. M-Kosanović , L. Nagy, G.Nagy:
In situ monitoring of the transpassivation and repassivation of the passive film on nitinol biomaterial by scanning electrochemical microscopy.
Electrochem. Commun. 107 (2019) 1–4, 106539. (IF: 4.333; Q1)
D. Filotas, B.M. Fernandez-Perez, L. Nagy, G. Nagy, R.M. Souto:
A novel Scanning Electrochemical Microscopy strategy for the investigation of anomalous hydrogen evolution from AZ63 magnesium alloy.
Sensors and Actuators: B. Chemical 308 (2020) 127691. (IF: 7.100; Q1)
A. Asserghine, M. Medvidovic-Kosanovic, L. Nagy, R. M. Souto, G. Nagy:
A study of the electrochemical reactivity of titanium under cathodic polarization by means of combined feedback and redox competition modes of scanning electrochemical microscopy.
Sensors and Actuators B: Chemical, 320 (2020) 128339. (IF: 7.100; Q1)
OTKA K104956: Nitroxidokat és előanyagaikat tartalmazó szenzorok és biomolekulák szintézise (T. Kálai, 18M HUF for 4 years)
OTKA K113177: Homogénkatalitikus aszimmetrikus karbonilezési reakciók és mechanizmus-vizsgálatuk (L. Kollár, 24M HUF for 4 years))
TÉT_12_RO-1-2013-0015: Highly effective voltammetric methods f for monoamine neurotransmitter assessments in complex biological matrices. (1.6 M HUF)
TÉT_12_RO-1-2013-0018: Mapping of Nitro-Oxidative Species by Scanning Electrochemical Microscopy with Micro(bio)sensors. (1.3 M HUF)
TÉT_12_CN-1-2012-0040: Modifying lateral strain in III-nitride-based epitaxial layers by selectively patterning sapphire substrates with CNT bundles and graphene fractions (Xiamen University, China, 9.6 M HUF + 0.3 M CNY)
2019-2.1.11-TÉT-2019-00042 Study on the pharmacological effectiveness of chiral methotrexate molecules surrounded by the chiral water clusters (Austria)
TÁMOP-4.2.2.A-11/1/KONV-2012-0065: Synthesis of supramolecular systems, their investigation and application in sensor chemistry. (170 M HUF) (total: 341M HUF for 2 years), PI: L. Kollár)
Chemical industry, pharmaceutical industry
PhD degrees obtained recently:
( between July 2018 and June 2020; indicated at www.doktori.hu)
PhD Thesis, 2019. (Research adviser: L. Kollár)
PhD Thesis, 2018. (Research adviser: L. Kollár)
PhD Thesis 2018 (Research adviser: T. Kálai)
PhD Thesis, 2018. (Research adviser: L. Nagy, G. Nagy)
PhD Thesis, 2020. (Research adviser: L. Kollár)
PhD Thesis, 2020. (Research adviser: B. Lemli)
PhD Thesis, 2020. (Research advisers: G. Nagy and L. Nagy)
