About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...



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Green Chemistry Research Group

  • Research concept
  • Members
  • Publications
  • Awarded projects
  • R and D results
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The dendrimers are one of the most important nanosize building blocks. Their technological and practical applications are also remarkable. Beside the industrial use of the dendrimers gain wide application also in pharmacology. The efforts aiming at the development of dendrimers, among them our present research, are focused on the synthesis of those ones able to form inclusion derivatives with the target compunds.

The first poly(amido)amidoamine (’PAMAM’) dendrimers were followed by more complicated structures containing further heteroatoms, cross-linkings and graphite-like substructures.

Our target compounds are the so-called host dendrimers which may gain application both in pharmacology and analytical chemistry.

The topics to be investigated

  • One of our goals is the synthesis of dendrimers containing either novel trisubstituted core or tetravinyl/tetraallylsilanes. Homogeneous catalysts of high chemo- and regioselectivities will be used. The preparation of higher generation dendrimers will be carried out by divergent methodologies, i.e., methodologies starting from the core unit.
  • The homogeneous catalysts will be exploited in the synthesis of amide-functionalised dendrimers, i.e., the synthesis of conventional structures will be carried out by novel reactions of high selectivity. On the other side, transition metal catalysed cross-coupling reactions will be used for the synthesis of novel dendritic structures.
  • Our basic compounds, serving as core derivatives, are 1,3,5-triiodobenzene, 2,4,6-triiodoaniline and silanes containing alkene functionalities. The iodoarene-type substrates and the silane derivatives are promising substrates in high-yielding carbonylation, coupling and hydroformylation reactions, respectively.


Dr. Tamas Kalai’s research is focused on synthesis and applications of stable nitroxide free radicals including the selective transformations of their functional groups in the presence of the free radical center. Extensive studies of stable nitroxide free radicals first appeared 60 years ago, and their application is rather diverse and extends beyond spin labeling. Stable nitroxide free radicals are used as co-oxidants in organic chemistry, building blocks for magnetic materials, superoxide dismutase mimics, antiproliferative compounds, mediators of polymerization, redox active materials in batteries, and magnetic resonance imaging (MRI) as well as electron paramagnetic resonance imaging (EPRI) contrast agents. These applications demand various scaffolds with diverse substitution patterns on pyrroline and piperidine nitroxides, including condensation with miscellaneous carbocycles and heterocycles. My colleagues and I are committed to fulfill these demands for both ‘in house’ and international cooperators.

Graphical abstracts of some recent selected publications are shown below:

Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides: Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T. Synthesis 2019, 51, 4463-4472.

Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates: Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T. Molecules 2020, 25, 2430.

Potential of Isotope Substitution in EPR Studies of Nitroxide Biradicals: Zaripov, R. B.; Khairutdinov, I. T.; Kálai, T.; Kish, K.; Kokorin, A. I.; Salikhov K. M. Applied Magnetic Resonance 2020, 51, 523–543.


Prof. Dr. László Kollár
(36) 72 / 503-600 / 24153
Prof. Dr. Kálmán Hideg
professor emeritus

Prof. Dr. Tamás Kálai
(36) 72 / 503-600 / 36220 (36221)
Prof. Dr. Géza Nagy
professor emeritus
(36) 72 / 503-600 / 24681
Dr. Lívia Nagy
senior research fellow
(36) 72 / 503-600 / 24688
Dr. Cecília Pápayné Sár
associate professor
(36) 72 / 503-600 / 31138 (36220)
Dr. Tamás Kégl
senior research fellow
(36) 72 / 503-600 / 24585
Dr. Barna Kovács
associate professor
(36) 72 / 503-600 / 24680
Dr. Sándor Kunsági-Máté
associate professor
(36) 72 / 503-600 / 35449
Dr. Beáta Lemli
assistant professor
(36) 72 / 503-600 / 35462
Dr. Zsolt Preisz
assistant research fellow
(36) 72 / 503-600 / 24802
Dr. László Kiss
research fellow
(36) 72 / 503-600 / 24802, (36) 20 / 946-7055
Kristóf Kecskés
laboratory technician
(36) 72 / 503-600 / 24802
Ferenc Kovács
assistant research fellow
(36) 72 / 503-600 / 24680
Dr. Attila Takács
research fellow
(36) 72 / 503-600 / 24120
Máté Gergely
assistant research fellow
(36) 72 / 503-600 / 29144
Gábor Mikle
assistant research fellow
(36) 72 / 503-600 / 24452
Zoltán Nagymihály
assistant research fellow
(36) 72 / 503-600 / 29144
Péter Szuroczki
assistant research fellow
(36) 72 / 503-600 / 24588
Asserghine Abdelilah
PhD student
(36) 70 / 559-0077
Diána Derdák
PhD student
Kinyua Muthuri Lawrence
PhD student
(36) 70 / 286-9307

Selected recent publications of the Green Chemistry Research Group

(Szentágothai Research Centre is indicated in the affiliation)


Total number of publications  (between July 2018  and June 2020)

Q1: 37, Q2:24, Q3: 8, Q4:

IF (Total):  211.001


P. Szuroczki, G. Mikle, L. Kollár:

Synthesis of oxazol derivatives from iodoalkenes via aminocarbonylation–cycloisomerization sequence in one-pot reaction.

Mol. Catal. 452 (2018) 68-74. ( Q1, IF: 2.938)

A. Abu Seni, L, Kollár, L. T. Mika, P. Pongrácz:

Rhodium-catalysed aryloxycarbonylation of iodo-aromatics by 4-substituted phenols with carbon monoxide or paraformaldehyde.

Mol. Catal. 457 (2018) 67-73. (Q1, IF: 2.938)

E. Sághy, M. Payrits, Z. Helyes, T. Bíró-Sütő, R. Skodáné Földes, E. Szánti-Pintér, J. Erostyák, G. Makkai, G. Sétáló Jr., L. Kollár, T. Kőszegi, R. Csepregi, J. Szolcsányi, E Szőke:

Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by modulation of lipid rafts.

J. Lipid Res.  59 (2018) 1851-1863. (Q1, IF: 4.743)

N. Pálinkás, L. Kollár, T. Kégl:

Palladium-Catalysed Synthesis of Amidines via Isonitrile Insertion.

ACS Omega 3 (2018) 16118−16126. ( Q1, IF: 2.584)

T. R. Kégl,, L. Kollár, T. Kégl:

Computational Characterization of Bidentate P-donor Ligands: Direct Comparision to Tolman’s Electronic Parameters.

Molecules 23 (2018) 3176; doi:10.3390/molecules23123176. (Q1, IF: 3.060)

E. Lempel, Zs. Őri, J. Szalma, B. V. Lovász, A. Kiss, Á. Tóth, S. Kunsági-Máté:

Effect of exposure time and pre-heating on the conversion degree of conventional, bulk-fill,      fiber reinforced and polyacid-modified resin composites.

Dental Materials 35 (2019) 217-228. (Q1, IF: 4.440)

S. Das, Z. Gazdag, L. Szente, M. Meggyes, Gy. Horváth, B. Lemli, S. Kunsági-Máté, M. Kuzma, T. Kőszegi:

Antioxidant and antimicrobial properties of randomly methylated β cyclodextrin – captured essential oils.

Food Chemistry 278 (2019) 305-313. (Q1, IF: 5.399)

Z. Faisal, S. Kunsági-Máté, B. Lemli, L. Szente, D. Bergmann, H. Humpf, M. Poór:

Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.

Molecules, 24 (2019) 1328. (Q1, IF: 3.060)

E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Dellafiora, C. Dall’ Asta, G. Cruciani, G. Pethő, M. Poór:

Interaction of Mycotoxin Alternariol with Serum Albumin.

Int. J. Mol. Sci. 20 (2019) 2352. (Q1, IF: 4.153)

B. Lemli, D. Derdák, P. Laczay, D. Kovács, S. Kunsági-Máte:

Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin.

Molecules 23 (2018) 1915-1924. (Q1, IF: 3.06)

V. Mohos, E. Fliszár-Nyúl, G. Schilli,Cs. Hetényi, B. Lemli, S. Kunsági-Máté, B. Bognár, M. Poór:

Interaction of Chrysin and Its Main ConjugatedMetabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide withSerum Albumin.

Int. J. Mol. Sci.  19 (2018) 4073-4087. (Q1, IF: 4.183)

A. Asserghine, D. Filotás, B. Németh, L. Nagy, G. Nagy:

Potentiometric scanning electrochemical microscopy for monitoring the pH distribution during the self-healing of passive titanium dioxide layer on titanium dental root implant exposed to physiological buffered (PBS) medium.

Electrochem. Commun. 95 (2018) 1. (Q1, IF: 4.197)

D. Filotás, B.M. Fernández-Pérez, A. Kiss, L. Nagy, G. Nagy, R.M. Souto:

Multi-barrel electrodes containing an internal micro-reference for the improved visualization of galvanic corrosion processes on magnesium-based materials using potentiometric scanning electrochemical microscopy.

Sensors & Actuators: B. Chemical (Ref. No.: SNB-D-19-00677R2). (Q1, IF: 6.393)

B. Bartal, G. Mikle, L. Kollár, P. Pongrácz:

Palladium-catalysed carbonylations of alkyl and alkenyl halides with formic acid as carbonyl source. Synthesis of α,β-unsaturated carboxylic acids and esters.

Mol. Catal. 467 (2019) 143−149. (Q1, IF: 2.938)

A. Abu Seni, L. Kollár, P. Pongrácz:

Palladium-catalysed intramolecular asymmetric cyclohydroaryloxycarbonylation of 2-allylphenol derivatives. Synthesis of chiral lactones via cyclocarbonylation.

Mol. Catal. 482 (2020) 110673. (IF: 3.687; Q1)

Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:

Solvent switched weak interaction of 4-quinazolinone with a cavitand derivative.

Molecules 25(8) (2020) 1915. (IF: 3.267; Q1))

Z. Preisz, Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:

Weak interaction of the antimetabolite drug methotrexate with a cavitand derivative.

Int. J. Mol. Sci.  21(12) (2020) 4345. (IF: 4.556; Q1)

Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T.:

Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides.

Synthesis  51 (2019) 4463-4472. (IF: 2.675; Q1)

Zsidó, B. Z.; Balog, M.; Erős, N.; Poór, M.; Mohos, V.; Fliszár-Nyúl, E.; Hetényi, Cs.; Masaki, N.; Hideg, K.; Kálai, T.; Bognár, B.:

Synthesis of spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity

Int. J. Mol. Sci. 21 (2019) 508. (IF: 4.556; Q1)

Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T.:

Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.         
Molecules 25 (2020) 2430. (IF: 3.267; Q1)

Z. Faisal, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

CyclodextrinsCanEntrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer.

Biomolecules 9 (2019) 354-362. (IF: 4.082, Q1)

E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer.

Biomolecules 9 (2019) 428-446. (IF: 4.082, Q1)

Z. Zelma, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

Interaction of zearalenone-14-sulfate with cyclodextrins and theremoval of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer.

J. Mol. Liq. 310 (2020) 113236. (IF: 5.065, Q1)

H. Mohamed Ameen, S. Kunsági-Máté, P. Noveczky, L. Szente, B. Lemli:

Adsorption of Sulfamethazine Drug onto the Modified Derivatives of Carbon Nanotubes at Different pH.

Molecules 25 (2020) 2489-2499. (IF: 3.267, Q1)

H. Yan, S. Lin, R. Zhang, H. Li, B. Fu, J. Liu, L. Liu, S. Kunsági-Máté, Y. An:

Facile synthesis of high-crystalline Bi2Se3 nanoribbons without Se vacancies and their properties.

J. Mat. Sci. 55 (2020) 5145-5155. (IF: 3.553, Q1)

V. Mohos, E. Fliszár-Nyúl, B. Lemli, B. Zsidó, Z. Balázs, Cs. Hetényi, P. Mladěnka, P. Horký, M. Pour, M. Poór:

Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metaboliteswith Human Serum Albumin and Cytochrome P450 Enzymes.

Biomolecules 10 (2020) 409-426. (IF: 4.082; Q1)

A. Asserghine, M. M-Kosanović , L. Nagy, G.Nagy:

In situ monitoring of the transpassivation and repassivation of the passive film on nitinol biomaterial by scanning electrochemical microscopy.

Electrochem.  Commun. 107 (2019) 1–4, 106539. (IF: 4.333;  Q1)

D. Filotas, B.M. Fernandez-Perez, L. Nagy, G. Nagy, R.M. Souto:

A novel Scanning Electrochemical Microscopy strategy for the investigation of anomalous hydrogen evolution from AZ63 magnesium alloy.

Sensors and Actuators: B. Chemical 308 (2020) 127691. (IF: 7.100;  Q1)

A. Asserghine, M. Medvidovic-Kosanovic, L. Nagy, R. M. Souto, G. Nagy:

A study of the electrochemical reactivity of titanium under cathodic polarization by means of combined feedback and redox competition modes of scanning electrochemical microscopy.

Sensors and Actuators B: Chemical, 320 (2020) 128339. (IF: 7.100;  Q1)

OTKA K104956: Nitroxidokat és előanyagaikat tartalmazó szenzorok és biomolekulák szintézise (T. Kálai, 18M HUF for 4 years)

OTKA K113177: Homogénkatalitikus aszimmetrikus karbonilezési reakciók és mechanizmus-vizsgálatuk (L. Kollár, 24M HUF for 4 years))

TÉT_12_RO-1-2013-0015: Highly effective voltammetric methods f for monoamine neurotransmitter assessments  in complex biological matrices. (1.6 M HUF)

TÉT_12_RO-1-2013-0018: Mapping of  Nitro-Oxidative Species by Scanning Electrochemical Microscopy with Micro(bio)sensors. (1.3 M HUF)

TÉT_12_CN-1-2012-0040: Modifying lateral strain in III-nitride-based epitaxial layers by selectively patterning sapphire substrates with CNT bundles and graphene fractions (Xiamen University, China, 9.6 M HUF + 0.3 M CNY)

2019-2.1.11-TÉT-2019-00042 Study on the pharmacological effectiveness of chiral methotrexate molecules surrounded by the chiral water clusters (Austria)

TÁMOP-4.2.2.A-11/1/KONV-2012-0065: Synthesis of supramolecular systems, their investigation and application in sensor chemistry. (170 M HUF) (total: 341M HUF for 2 years), PI: L. Kollár)

  • 210 publications (in international journals, cumulative impact ca. 460); 1900 independent citations
  • 9 basic patents in pharmaceutical and pesticide chemistry (announced in more than 30 countries).
  • 25 years cooperation with Gedeon Richter Pharmaceutical Works Ltd. (steroid chemistry group). Synthesis of novel, diphenyl ether-based pesticides (Budapest Chemical Works). Investigation of the copigmentation in red wines (Vylyan Viticulture).

Chemical industry, pharmaceutical industry

  • Development of carbonylation catalysts of high selectivity.
  • Synthesis of iodo-containing and silane substrates able to form dendritic cores.
  • Structural determination of first- (second-, third-) generation dendrimers.
  • Investigation of the practical application of dendrimers.
  • Laboratory devices necessary to carry out synthesis of dendrimers (inert Schlenk-technique, high-pressure autoclaves)
  • Analytical methods (400 MHz NMR, FT-IR-Raman, MS, fluorimetric methods)


Green chemistry research group

Bruker NMR Ascend 500MHz

PhD  degrees obtained recently:

( between July 2018 and June 2020; indicated at www.doktori.hu)

  • Tímea Kégl:  Investigation of resorcinarene-based supramolecular systems via synthetic and theoretical methods.

           PhD Thesis, 2019.  (Research adviser: L. Kollár)

  • Diána Marosvölgyi-Haskó: Aminocarbonylation of iodoaromtics.

           PhD Thesis, 2018.  (Research adviser: L. Kollár)

  • Györgyi Úr: Synthesis of new 3,4-disubstituted pyrrolinenitroxides and their further synthetic applications

           PhD Thesis 2018 (Research adviser: T. Kálai)

  • Filotás Dániel: Microelectrochemical imaging of corrosion reactions.

           PhD Thesis, 2018.  (Research adviser: L. Nagy, G. Nagy)

  • Abu Seni Anas:  Transition metal-catalyzed (hydro)aryloxycarbonylation reactions.

           PhD Thesis, 2020.  (Research adviser: L. Kollár)

  • Mohamed Ameen Hiba Farooq: Encapsulation of sulfamethazine drug by b-cyclodextrins and its adsorption on functionalized carbon nanotubes.

           PhD Thesis, 2020.  (Research adviser: B. Lemli)

  • Abdelilah Asserghine: Microelectrochemical characterization titanium biomaterials by scanning electrochemical microscopy,

           PhD Thesis, 2020. (Research advisers: G. Nagy and L. Nagy)

Prof. Dr. László Kollár
Research Group Leader
 (36) 72 / 503-600 / 24153