A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...



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Zöldkémiai Kutatócsoport

  • Kutatási koncepció
  • Munkatársak
  • Publikációk
  • Elnyert pályázatok
  • K+F+I eredmények
  • Szolgáltatások
  • Laboratóriumok, műszerek
  • Galéria
  • Hallgatóink eredményei
  • Dokumentumok

The synthesis of carboxamido-functionalised heterocycles via homogeneous catalytic reactions is planned. Homogeneous thio- and selenocarbonylations will be carried out by using either CS/CSe (together with conventional O- and N-nucleophiles) or CO (together with S- and Se-nucleophiles). As a green approach, the aplication of 3d metals (instead of platinum metals), biomass-based solvents (instead of conventional organic sovents) and CO-surrogates (instead of gaseous C)) is in the forefront of the research activity of the next years. 

We plan the synthesis of paramagnetic a-aminophosphonates, P-containing 3,4-disubstituted pyrroline nitroxides. Finding new possibilities of C-C bond forming reactions in the presence of stable nitroxide free radicals, (carbonylation, CH functionalization) is also among our aims. The synthesis and study of new SH-specific spin labels and design of new neuroprotective hybrid molecules and/or theranostic agents are our continuous challenges for a decade.

We also intend to synthesize novel biradical compounds with non-rigid scaffolds and study their spin-spin interactions. We also wish would synthesize paramagnetic pendamethalin derivatives to study the xenobiotic interactions with humic acid/clay models.

The weak interaction between bioactive molecules and their targets is in the focus of of our group. Both the effect of the molecular environment on the interaction between the bioactive molecules and their targets and the interaction of bioactive molecules with the elements of cell membranes are investigated by the highly sensitive photoluminescence studies. The effect of the composition of the solvent mixtures on the stabilities of the cavity-shaped molecules including different cavitand derivatives are planned to study. Molecular vibrations as key molecular motions will be examined in detail to describe its role on the entropy term associated to the molecular interactions.

Either the detection of the enantiomers of methotrexate and other bioactive molecules is planned to be improved due to the analytical purposes.

Further work is planned for studying corrosion properties of 3D printed medical implants made of titanium alloys. Specific interest has been turned up about effects of heat treatment and parameters of printing technology on corrosion resistance and on kinetics of building op passive surface film. Supporting methods as atomic absortion spectroscopy for   elementary analysis will be applied as well. (AAS measurements has been carried on in collaboration with geologist and environmental researchers.) In these studies we plan to collaborate with a group of engineering faculty.  working together with researchers of the Institute of Biology we are planning to use our recently improved H2S measuring methods in studying whine fermentation processes.  A bilateral (Hungary – France) research plan gained support recently. In the framework of it research will be carried on to improve electro-catalytic CO2 method. The new chronopotentiometric antioxidant measuring method recently invented will be further studied studying perspective application fields and finding more stable electro catalyst.  The scanning electrochemical microscopy (SECM) method and other applications of chemical an biochemical ultramicro electrodes will go on.

Prof. Dr. Kollár László
egyetemi tanár
(36) 72 / 503-600 / 24153
Prof. Dr. Hideg Kálmán
emeritus professzor

Prof. Dr. Kálai Tamás
egyetemi tanár
36220 / 36221
Prof. Dr. Nagy Géza
emeritus professzor
Dr. Nagy Lívia
tudományos főmunkatárs
Dr. Sár Cecília Pápayné
31138 / 36220
Dr. Kégl Tamás
tudományos főmunkatárs
Dr. Kovács Barna
Dr. Kunsági-Máté Sándor
Dr. Lemli Beáta
Dr. Preisz Zsolt
tudományos segédmunkatárs
Dr. Kiss László
tudományos munkatárs
24802 / +36209467055
Kecskés Kristóf
laboratóriumi technikus
Kovács Ferenc
tudományos segédmunkatárs
Balog Mária
laboratóriumi technikus

31793 / 31671
Kish Krisztina
laboratóriumi technikus

Dr. Takács Attila
tudományos munkatárs
(36) 72 / 503-600 / 24120
Gergely Máté
tudományos segédmunkatárs
(36) 72 / 503-600 / 29144
Mikle Gábor
tudományos segédmunkatárs
(36) 72 / 503-600 / 24452
Nagymihály Zoltán
tudományos segédmunkatárs
(36) 72 / 503-600 / 29144
Szuroczki Péter
tudományos segédmunkatárs
(36) 72 / 503-600 / 24588
Abdelilah Asserghine
PhD hallgató
(36) 70 / 559-0077
Derdák Diána
PhD hallgató
Lawrence Kinyua Muthuri
PhD hallgató
(36) 70 / 286-9307

Selected recent publications of the Green Chemistry Research Group

(Szentágothai Research Centre is indicated in the affiliation)


Total number of publications  (between July 2018  and December 2021)

Q1: 57 (among them 10 D1), Q2: 39, Q3: 13, Q4: 6

IF (Total):  377.514


P. Szuroczki, G. Mikle, L. Kollár:

Synthesis of oxazol derivatives from iodoalkenes via aminocarbonylation–cycloisomerization sequence in one-pot reaction.

Mol. Catal. 452 (2018) 68-74. ( Q1, IF: 2.938)

A. Abu Seni, L, Kollár, L. T. Mika, P. Pongrácz:

Rhodium-catalysed aryloxycarbonylation of iodo-aromatics by 4-substituted phenols with carbon monoxide or paraformaldehyde.

Mol. Catal. 457 (2018) 67-73. (Q1, IF: 2.938)

E. Sághy, M. Payrits, Z. Helyes, T. Bíró-Sütő, R. Skodáné Földes, E. Szánti-Pintér, J. Erostyák, G. Makkai, G. Sétáló Jr., L. Kollár, T. Kőszegi, R. Csepregi, J. Szolcsányi, E Szőke:

Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by modulation of lipid rafts.

J. Lipid Res.  59 (2018) 1851-1863. (Q1, IF: 4.743)

N. Pálinkás, L. Kollár, T. Kégl:

Palladium-Catalysed Synthesis of Amidines via Isonitrile Insertion.

ACS Omega 3 (2018) 16118−16126. (Q1, IF: 2.584)

T. R. Kégl,, L. Kollár, T. Kégl:

Computational Characterization of Bidentate P-donor Ligands: Direct Comparision to Tolman’s Electronic Parameters.

Molecules 23 (2018) 3176; doi:10.3390/molecules23123176. (Q1, IF: 3.060)

E. Lempel, Zs. Őri, J. Szalma, B. V. Lovász, A. Kiss, Á. Tóth, S. Kunsági-Máté:

Effect of exposure time and pre-heating on the conversion degree of conventional, bulk-fill,      fiber reinforced and polyacid-modified resin composites.

Dental Materials 35 (2019) 217-228. (Q1, IF: 4.440)

S. Das, Z. Gazdag, L. Szente, M. Meggyes, Gy. Horváth, B. Lemli, S. Kunsági-Máté, M. Kuzma, T. Kőszegi:

Antioxidant and antimicrobial properties of randomly methylated β cyclodextrin – captured essential oils.

Food Chemistry 278 (2019) 305-313. (Q1, IF: 5.399)

Z. Faisal, S. Kunsági-Máté, B. Lemli, L. Szente, D. Bergmann, H. Humpf, M. Poór:

Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.

Molecules, 24 (2019) 1328. (Q1, IF: 3.060)

E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Dellafiora, C. Dall’ Asta, G. Cruciani, G. Pethő, M. Poór:

Interaction of Mycotoxin Alternariol with Serum Albumin.

Int. J. Mol. Sci. 20 (2019) 2352. (Q1, IF: 4.153)

B. Lemli, D. Derdák, P. Laczay, D. Kovács, S. Kunsági-Máte:

Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin.

Molecules 23 (2018) 1915-1924. (Q1, IF: 3.06)

V. Mohos, E. Fliszár-Nyúl, G. Schilli,Cs. Hetényi, B. Lemli, S. Kunsági-Máté, B. Bognár, M. Poór:

Interaction of Chrysin and Its Main ConjugatedMetabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide withSerum Albumin.

Int. J. Mol. Sci.  19 (2018) 4073-4087. (Q1, IF: 4.183)

A. Asserghine, D. Filotás, B. Németh, L. Nagy, G. Nagy:

Potentiometric scanning electrochemical microscopy for monitoring the pH distribution during the self-healing of passive titanium dioxide layer on titanium dental root implant exposed to physiological buffered (PBS) medium.

Electrochem. Commun. 95 (2018) 1. (Q1, IF: 4.197)

D. Filotás, B.M. Fernández-Pérez, A. Kiss, L. Nagy, G. Nagy, R.M. Souto:

Multi-barrel electrodes containing an internal micro-reference for the improved visualization of galvanic corrosion processes on magnesium-based materials using potentiometric scanning electrochemical microscopy.

Sensors & Actuators: B. Chemical (Ref. No.: SNB-D-19-00677R2). (Q1, IF: 6.393)

B. Bartal, G. Mikle, L. Kollár, P. Pongrácz:

Palladium-catalysed carbonylations of alkyl and alkenyl halides with formic acid as carbonyl source. Synthesis of α,β-unsaturated carboxylic acids and esters.

Mol. Catal. 467 (2019) 143−149. (Q1, IF: 2.938)

A. Abu Seni, L. Kollár, P. Pongrácz:

Palladium-catalysed intramolecular asymmetric cyclohydroaryloxycarbonylation of 2-allylphenol derivatives. Synthesis of chiral lactones via cyclocarbonylation.

Mol. Catal. 482 (2020) 110673. (IF: 3.687; Q1)

Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:

Solvent switched weak interaction of 4-quinazolinone with a cavitand derivative.

Molecules 25(8) (2020) 1915. (IF: 3.267; Q1)

Z. Preisz, Z. Nagymihály, B. Lemli, L. Kollár, S. Kunsági-Máté:

Weak interaction of the antimetabolite drug methotrexate with a cavitand derivative.

Int. J. Mol. Sci.  21(12) (2020) 4345. (IF: 4.556; Q1)

Isbera, M.; Bognár, B.; Gulyás-Fekete, G.; Kish, K.; Kálai, T.:

Syntheses of Pyrazine-, Quinoxaline-, and Imidazole-Fused Pyrroline Nitroxides.

Synthesis  51 (2019) 4463-4472. (IF: 2.675; Q1)

Zsidó, B. Z.; Balog, M.; Erős, N.; Poór, M.; Mohos, V.; Fliszár-Nyúl, E.; Hetényi, Cs.; Masaki, N.; Hideg, K.; Kálai, T.; Bognár, B.:

Synthesis of spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity

Int. J. Mol. Sci. 21 (2019) 508. (IF: 4.556; Q1)

Isbera, M.; Bognár, B.; Jekő, J.; Sár, C.; Hideg, K.; Kálai, T.:

Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.         
Molecules 25 (2020) 2430. (IF: 3.267; Q1)

Z. Faisal, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

CyclodextrinsCanEntrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer.

Biomolecules 9 (2019) 354-362. (IF: 4.082, Q1)

E. Fliszár-Nyúl, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

Interactions of Mycotoxin Alternariol with Cyclodextrins and its Removal from Aqueous Solution by Beta-Cyclodextrin Bead Polymer.

Biomolecules 9 (2019) 428-446. (IF: 4.082, Q1)

Z. Zelma, E. Fliszár-Nyúl, L. Dellafiora, G. Galaverna, C. Dall'Asta, B. Lemli, S. Kunsági-Máté, L. Szente, M. Poór:

Interaction of zearalenone-14-sulfate with cyclodextrins and theremoval of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer.

J. Mol. Liq. 310 (2020) 113236. (IF: 5.065, Q1)

H. Mohamed Ameen, S. Kunsági-Máté, P. Noveczky, L. Szente, B. Lemli:

Adsorption of Sulfamethazine Drug onto the Modified Derivatives of Carbon Nanotubes at Different pH.

Molecules 25 (2020) 2489-2499. (IF: 3.267, Q1)

H. Yan, S. Lin, R. Zhang, H. Li, B. Fu, J. Liu, L. Liu, S. Kunsági-Máté, Y. An:

Facile synthesis of high-crystalline Bi2Se3 nanoribbons without Se vacancies and their properties.

J. Mat. Sci. 55 (2020) 5145-5155. (IF: 3.553, Q1)

V. Mohos, E. Fliszár-Nyúl, B. Lemli, B. Zsidó, Z. Balázs, Cs. Hetényi, P. Mladěnka, P. Horký, M. Pour, M. Poór:

Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metaboliteswith Human Serum Albumin and Cytochrome P450 Enzymes.

Biomolecules 10 (2020) 409-426. (IF: 4.082; Q1)

A. Asserghine, M. M-Kosanović , L. Nagy, G.Nagy:

In situ monitoring of the transpassivation and repassivation of the passive film on nitinol biomaterial by scanning electrochemical microscopy.

Electrochem.  Commun. 107 (2019) 1–4, 106539. (IF: 4.333;  Q1)

D. Filotas, B.M. Fernandez-Perez, L. Nagy, G. Nagy, R.M. Souto:

A novel Scanning Electrochemical Microscopy strategy for the investigation of anomalous hydrogen evolution from AZ63 magnesium alloy.

Sensors and Actuators: B. Chemical 308 (2020) 127691. (IF: 7.100;  Q1)

A. Asserghine, M. Medvidovic-Kosanovic, L. Nagy, R. M. Souto, G. Nagy:

A study of the electrochemical reactivity of titanium under cathodic polarization by means of combined feedback and redox competition modes of scanning electrochemical microscopy.

Sensors and Actuators B: Chemical, 320 (2020) 128339. (IF: 7.100;  Q1)

Isbera, M.; Bognár, B.; Gallyas, F.; Bényei, A.; Jekő, J.; Kálai, T:

Syntheses and Study of a Pyrroline Nitroxide Condensed Phospholene Oxide and a Pyrroline Nitroxide Attached Diphenylphosphine.

Molecules 2021, 26, 4366. (IF: 4.410;  Q1)

Andreidesz, K.; Szabo, A.; Kovacs, D.; Koszegi, B.; Bagone Vantus, V.; Vamos, E.; Isbera, M.; Kalai, T.; Bognar, Z.; Kovacs, K.; Gallyas, F.

Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines.

Int. J. Mol. Sci. 2021, 22, 9016. (IF: 5.923;  Q1)

Eszter Fliszár-Nyúl, Zelma Faisal, Violetta Mohos, Diána Derdák, Beáta Lemli, Tamás Kálai, Cecília Sár, Balázs Z. Zsidó, Csaba Hetényi, Ádám I. Horváth, Zsuzsanna Helyes, Ruth Deme, Dóra Bogdán, Andrea Czompa, Péter Mátyus, Miklós Poór,

Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin,

J. Mol. Liquid., Vol. 333, 2021, 115945. (IF: 6.156;  Q1)

Preisz, Z.; Nagymihály, Z.; Kollár, L.; Kálai, T.; Kunsági-Máté, S.

Weak Interactions of the Isomers of Phototrexate and Two Cavitand Derivatives.

Int. J. Mol. Sci. 2021, 22, 10764. (IF: 5.923;  Q1)

Preisz, Z.; Hartvig, N.; Bognár, B.; Kálai, T.; Kunsági-Máté, S.

Comparative EPR Study on the Scavenging Effect of Methotrexate with the Isomers of Its Photoswitchable Derivative.

Pharmaceuticals 2021, 14, 665. (IF: 5.863;  Q1)

Kovács, F.; Yan, H.; Li, H.; Kunsági-Máté, S.

Temperature-Induced Change of Water Structure in Aqueous Solutions of Some Kosmotropic and Chaotropic Salts.

Int. J. Mol. Sci. 2021, 22, 12896. (IF: 5.923;  Q1)

Fliszár-Nyúl, E.; Lemli, B.; Kunsági-Máté, S.; Poór, M.

Effects of Microenvironmental Changes on the Fluorescence Signal of Alternariol: Magnesium Induces Strong Enhancement in the Fluorescence of the Mycotoxin.

Int. J. Mol. Sci. 2021, 22, 8692. (IF: 5.923;  Q1)

Edina Lempel, Zsuzsanna Őri, Dóra Kincses, Bálint Viktor Lovász, Sándor Kunsági-Máté, József Szalma.

Degree of conversion and in vitro temperature rise of pulp chamber during polymerization of flowable and sculptable conventional, bulk-fill and short-fibre reinforced resin composites,

Dental Materials,Vol. 37, Issue 6, 2021, Pages 983-997. (IF: 5.304;  Q1)

Kincses, D.; Böddi, K.; Őri, Z.; Lovász, B.V.; Jeges, S.; Szalma, J.; Kunsági-Máté, S.; Lempel, E.

Pre-Heating Effect on Monomer Elution and Degree of Conversion of Contemporary and Thermoviscous Bulk-Fill Resin-Based Dental Composites.

Polymers 2021, 13, 3599. (IF: 4.329;  Q1)

Zelma Faisal, Violetta Mohos, Eszter Fliszár-Nyúl, Kateřina Valentová, Kristýna Káňová, Beáta Lemli, Sándor Kunsági-Máté, Miklós Poór.

Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6, and 3A4) enzymes,

Biomedicine & Pharmacotherapy, Vol. 138, 2021, 111459. (IF: 6.529;  Q1)

Ala’ Salem, Alexandra Hagymási, Barbara Vörös-Horváth, Tatjana Šafarik, Tomislav Balić, Péter Szabó, Fruzsina Gősi, Sándor Nagy, Szilárd Pál, Sándor Kunsági-Máté, Aleksandar Széchenyi.

Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control,

European Journal of Pharmaceutical Sciences, Vol. 156, 2021, 105599. (IF: 4.384;  Q1)

Hui Yan, Huiqi Yang, Sai Lin, Jinbo He, László Kiss, Sándor Kunsági-Máté, Meng Zhang, Heng Li,

Effect of staged methane flow on morphology and growth rate of graphene monolayer domains by low-pressure chemical vapor deposition,

Thin Solid Films, Vol. 736, 2021, 138921. (IF: 2.183;  Q2)

Kiss, L. ; Kovács, F. ; Kunsági-Máté, S.

Role of allyl alcohol and sodium 4-vinylbenzenesulphonate in the electrooxidation of phenol

Chem. Phys. Letters, 764, 2021, 138270. (IF: 2.328;  Q2)

Preisz Z, Kunsági-Máté S.

Effect of methotrexate and its photodegradation products on the temperature induced denaturation of human serum albumin.

Spectrochim Acta A Mol Biomol Spectrosc. 2021; 245: 118905. (IF: 4.098;  Q2)

Kovács, F. and Kunsági-Máté, S.

Change of liquid water structure under the presence of phosphate anion during changing its kosmotropic character to chaotropic along its deprotonation route.

Chem. Phys. Letters, Vol. 756, 2020. (IF: 2.328;  Q2)

Kiss, L. and Kunsági-Máté, S.

pH-dependent electrodeposition reaction of 2-phenoxyethanol in aqueous environment and adsorption of phenols on modified surfaces.

Chem. Phys. Letters, Vol. 759, 2020. (IF: 2.328;  Q2)

Faisal, Z., Vörös, V., Fliszár-Nyúl, E. et al.

Interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with serum albumin.

Mycotoxin Res 36, 389–397, 2020. (IF: 3.833;  Q2)

Abdelilah Asserghine, Martina Medvidović-Kosanović, Livia Nagy, Ricardo M. Souto, Geza Nagy.

A study of the electrochemical reactivity of titanium under cathodic polarization by means of combined feedback and redox competition modes of scanning electrochemical microscopy,

Sensors and Actuators B: Chem., Vol. 320, 2020, 128339. (IF: 7.460;  Q1)

Abdelilah Asserghine, Martina Medvidović-Kosanović, Anamarija Stanković, Lívia Nagy, Ricardo M. Souto, Géza Nagy.

A scanning electrochemical microscopy characterization of the localized corrosion reactions occurring on nitinol in saline solution after anodic polarization,

Sensors and Actuators B: Chem., Vol. 321, 2020, 128610. (IF: 7.460;  Q1)

D. Filotás, A. Asserghine, T. Nagy, L. Asztalos, F. Kovács, J. Dobránszky, L. Nagy, G. Nagy

Nickel coated graphite microparticle based electrodes for carbon dioxide reduction in monoethanolamine medium.

Electroanalysis, 33, 2021, 208-215. (IF: 2.544;  Q2)

Lawrence Kinyua Muthuri, Livia Nagy, Geza Nagy.

Chronopotentiometric method for assessing antioxidant activity: A reagentless measuring technique,

Electrochemistry Communications, Vol. 122, 2021, 106907. (IF: 4.724;  Q1)

D. Filotás, B.M. Fernández-Pérez, L. Nagy, G. Nagy, R.M. Souto.

Investigation of anomalous hydrogen evolution from anodized magnesium using a polarization routine for scanning electrochemical microscopy,

Journal of Electroanalytical Chemistry, Vol. 895, 2021, 115538. (IF: 3.012;  Q1)

D. Filotás, L. Nagy, G. Nagy, R.M. Souto.

New insights on the influence of aluminum on the anomalous hydrogen evolution of anodized magnesium using scanning electrochemical microscopy,

Electrochimica Acta, Vol. 391, 2021, 138915. (IF: 6.901;  Q1)

Abdelilah Asserghine, Amir M. Ashrafi, Atripan Mukherjee, Frantisek Petrlak, Zbynek Heger, Pavel Svec, Lukas Richtera, Livia Nagy, Ricardo M. Souto, Geza Nagy, and Vojtech Adam.

In Situ Investigation of the Cytotoxic and Interfacial Characteristics of Titanium When Galvanically Coupled with Magnesium Using Scanning Electrochemical Microscopy

ACS Applied Materials & Interfaces 2021 13 (36), 43587-43596. (IF: 9.229;  Q1)

Soma J. Keszei, Péter Pekker, Csaba Fehér, Szabolcs Balogh, Miklós Jakab, Lívia Nagy, Rita Skoda-Földes.

Application of sol-gel methods to obtain silica materials decorated with ferrocenyl-ureidopyrimidine moieties. Preparation of hollow spheres and modification of a carbon electrode,

Microporous and Mesoporous Materials, Vol. 308, 2020, 110380. (IF: 5.455;  Q1)

L. Orha, Á. Papp, J. M. Tukacs, L. Kollár, L. T. Mika.

Tetrabutylphosphonium 4-ethoxyvalerate as a safer media for homogeneous palladium-catalyzed Hiyama-coupling reactions.

Chemical Papers 74, 2020, 4593-4598. (IF: 2.097;  Q2)

N. Pálinkás, G. Mikle, A. Aranyi, A. Péter, L. Kollár.

Synthesis of Axially Chiral Carboxamides via Aminocarbonylation of Aryl and Vinyl Iodides with 2,2’-Diamino-1,1’-binaphthalene in the Presence of Palladium Catalysts.

Chemistry Select 2020, 5, 11048. (IF: 2.109;  Q2)

Kégl, T.R.; Kollár, L.; Kégl, T.

DFT Study on the Mechanism of Iron-Catalyzed Diazocarbonylation.

Molecules 2020, 25, 5860. (IF: 4.411;  Q2)

Szemenyei, B.; Novotny, B.; Zsolnai, S.; Miskolczy, Z.; Biczók, L.; Takács, A.; Kollár, L.; Drahos, L.; Móczár, I.; Huszthy, P.

Push or Pull for a Better Selectivity? A Study on the Electronic Effects of Substituents of the Pyridine Ring on the Enantiomeric Recognition of Chiral Pyridino-18-Crown-6 Ethers. Symmetry 2020, 12, 1795. (IF: 2.713;  Q2)

G. Mikle, A. Zugó, E. Szatnik, A. Maxim, S. Mahó, L. Kollár.

Synthesis of novel pregnane-based 20-carboxamides via palladium-catalysed aminocarbonylation.

Chem. Pap. 75, 1861–1867, 2021. (IF: 2.097;  Q2)

G. Mikle, P. Noveczky, S. Mahó, L. Kollár.

Palladium-catalysed amino-vs. Alkoxycarbonylation of iodoalkenes using bifunctional N,O-nucleophiles,

Tetrahedron, Vol. 85, 2021, 132050. (IF: 2.457;  Q2)

L. Kollár, A. Kovács, T. Kégl, P. Huszthy, P.Pongrácz.

Coordination chemistry of platinum(II) and rhodium(I) complexes containing chiral monophosphacrown ether ligands,

Inorganica Chimica Acta, Vol. 522, 2021, 120348. (IF: 2.545;  Q2)

Kollár, L.; Erdélyi, Á.; Rasheed, H.; Takács, A.

Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation.

Molecules 2021, 26, 1813. (IF: 4.411;  Q1)

G. Mikle, F. Bede, L. Kollár.

Synthesis of N-picolylcarboxamides in aminocarbonylation,

Tetrahedron, Vol. 88, 2021, 132128. (IF: 2.457;  Q2)

G. Mikle, R. Skoda-Földes, L. Kollár.

Amino- and azidocarbonylation of iodoalkenes,

Tetrahedron, Vol. 100, 2021, 132495. (IF: 2.457;  Q2)









OTKA K104956: Nitroxidokat és előanyagaikat tartalmazó szenzorok és biomolekulák szintézise (T. Kálai, 18M HUF for 4 years)

OTKA K113177: Homogénkatalitikus aszimmetrikus karbonilezési reakciók és mechanizmus-vizsgálatuk (L. Kollár, 24M HUF for 4 years))

TÉT_12_RO-1-2013-0015: Highly effective voltammetric methods f for monoamine neurotransmitter assessments  in complex biological matrices. (1.6 M HUF)

TÉT_12_RO-1-2013-0018: Mapping of  Nitro-Oxidative Species by Scanning Electrochemical Microscopy with Micro(bio)sensors. (1.3 M HUF)

TÉT_12_CN-1-2012-0040: Modifying lateral strain in III-nitride-based epitaxial layers by selectively patterning sapphire substrates with CNT bundles and graphene fractions (Xiamen University, China, 9.6 M HUF + 0.3 M CNY)

2019-2.1.11-TÉT-2019-00042 Study on the pharmacological effectiveness of chiral methotrexate molecules surrounded by the chiral water clusters (Austria)

TÁMOP-4.2.2.A-11/1/KONV-2012-0065: Synthesis of supramolecular systems, their investigation and application in sensor chemistry. (170 M HUF) (total: 341M HUF for 2 years), PI: L. Kollár)

NKFI 138184 Investigation of pharmacokinetic/toxicokinetic interactions of mycotoxins and polyphenols (Kunsági-Máté Sándor, 2021-2025, 110.000 EUR / 39.250.000 HUF)

NKFI 125166 Investigation of the interactions of mycotoxins with albumin and cyclodextrins (Kunsági-Máté Sándor, 2017-2021, 51.400 EUR / 18.492.000 HUF)

NKFIH K 125244 Új, ultra-mikro méretű ionszelektív elektródokat alkalmazó pásztázó elektrokémiai mikroszkópiás (PEKM) módszerek kidolgozása és alkalmazása egyes korróziós folyamatok sajátságainak felfedezésére (Nagy Géza, Nagy Lívia, Kiss András, 2017-2022, 116.315 EUR / 42.455.000 HUF)

Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary within the framework of the 2020-4.1.1.-TKP2020 Innovation for sustainable and healthy living and environment thematic programme of the UP (Kollár László, Kunsági-Máté Sándor, 2020-2021, ca. 210.000 EUR / ca.75.000.000 HUF)

Research Group of Eötvös Loránd Research Network (Tamás Kálai, Judit Pongrácz, 2022-2027, 30 000 EUR)

NKFIH K 138199 PEKM módszerek fejlesztése és alkalmazása korróziós és elektrokatalitikus folyamatokhoz (Nagy Géza, Nagy Lívia, Kiss András, 2021-2024, rejected)

Palladium-catalysed carbonylation reactions werecarried out under environtally benign conditions in order t functionalyze aromatic heterocycles of pharmacological importance. In this way, triazol- and imidazopiridin-based carbocamides were synthesized (collaboration with Molecular Pharmacology RG at SzRC). Novel 2-methylresorcinarene-based cavitands were synthesized and used in host-guest chemistry.

Synthesis of new paramagnetic phosphorus compounds including paramagnetic alfa,beta-ketophosphonate esters, allylic phosphonate esters, bisphosphonates, pyrroline nitroxide condensed phospholene oxide and a paramagnetic phosphine. The former was used to generate phosphonium salt as a mitochondria targeted compound, which was tested on breast cancer cell lines. New spin-labelled version of chantix was developed. The metabolites of SZV 1287, and SZV 1287 itself, which is a novel semicarbazide-sensitive amine oxidase (SSAO) inhibitor and a promising candidate to be a novel analgesic for the treatment of neuropathic pain, were synthesized and tested with interaction of serum albumin (collaboration with Molecular Pharmacology RG at SzRC).

Investigation of weak inclusion complexes involving a cavitand derivative (as host) and an antimetabolite drug, methotrexate (as guest) in dimethyl sulfoxide. Interactions of two conformers of newly synthesized photoswitchable azobenzene analogue of methotrexate, called Phototrexate with two cavitand derivatives have also been investigated. Results show opposite temperature-dependence of complex stabilities with the two conformers. These results can support the therapeutic application of the photoswitchable phototrexate, because the formation of inclusion complexes is a promising method to regulate the pharmacokinetics of drug molecules.

Effect of the photodegradation of methotrexate on the denaturation of human serum albumin has been studied. The calorimetric measurements show elevated activation energy in the presence of methotrexate. Scavenging effect of the antimetabolite dihydrofolate reductase inhibitor methotrexate and the isomers of its photoswitchable derivate, cis- and trans-phototrexate (PHX) have been compared by ESR spectroscopy, with the application of a cyclic hydroxylamine spin probe. Direct antioxidant properties of the investigated molecules were measured by ABTS scavenging assay, which showed no significant difference between trans-PHX and cis-PHX.

The Scanning Electrochemical Microscopy methods were further developed and used for studying fine details of different corrosion processes,. among them corrosion of magnesium alloys, 3D printed metal objects (Collaboration with PTE Engeneering Faculty) and titanium alloys used in dental implant making. A new reagentless, antioxidant measuring method was developed. The method uses chemically modified electrode and two step chronopotentiometric detection. A method for accessing traces of hydrogen sulfide has been developed and its applicability for whine fermentation and quality checking has been tested. The method uses highly sensitive potentiometric air gap detection (collaboration with PTE TTK Institute of Biology).

  • 210 publikáció (nemzetközi folyóiratokban, összesített hatástényező kb. 460); 1900 független hivatkozás
  • 9 alapszabadalom a gyógyszerkémia és a növényvédőszer-kémia területén (a világ kb. 30 országában bejelentve).
  • Több mint 25 éves együttműködés a Richter Gedeon Vegyészeti Gyár Rt. szteroidkémiai kutatócsoportjával. Új, difeniléter típusú növényvédőszerek szintézise (Budapesti Vegyiművek). Vörösborok kopigmentációjának vizsgálata és értelmezése (Vylyan Szőlőbirtok és Pincészet).

Vegyipar, gyógyszeripar.

  • Nagyszelektivitású karbonilező katalizátorok kifejlesztése.
  • Dendrimer központi magként használható jódtartalmú szubsztrátumok (jódalkének, jódarének, szilánok) szintézise.
  • Az első- (másod-, harmad-) generációs dendrimerek szerkezetének meghatározása, analitikai módszerek kidolgozása.
  • A dendrimerek gyakorlati alkalmazhatóságának vizsgálata.
  • dendrimerek szintéziséhez szükséges technika (inert Schlenk technika, nagynyomású autoklávok)
  • analitikai vizsgálati módszerek (400 MHz NMR, FT-IR-Raman, különböző MS technikák, fluorimetriás módszerek)

Zöldkémiai Kutatócsoport

MicroSYNTH mikrohullámú reaktor

Labor részegységei

Bruker NMR Ascend 500MHz készülék

PhD  degrees obtained recently:

( between July 2018 and June 2020; indicated at www.doktori.hu)

  • Tímea Kégl:  Investigation of resorcinarene-based supramolecular systems via synthetic and theoretical methods.

           PhD Thesis, 2019.  (Research adviser: L. Kollár)

  • Diána Marosvölgyi-Haskó: Aminocarbonylation of iodoaromtics.

           PhD Thesis, 2018.  (Research adviser: L. Kollár)

  • Györgyi Úr: Synthesis of new 3,4-disubstituted pyrrolinenitroxides and their further synthetic applications

           PhD Thesis 2018 (Research adviser: T. Kálai)

  • Filotás Dániel: Microelectrochemical imaging of corrosion reactions.

           PhD Thesis, 2018.  (Research adviser: L. Nagy, G. Nagy)

  • Abu Seni Anas:  Transition metal-catalyzed (hydro)aryloxycarbonylation reactions.

           PhD Thesis, 2020.  (Research adviser: L. Kollár)

  • Mohamed Ameen Hiba Farooq: Encapsulation of sulfamethazine drug by b-cyclodextrins and its adsorption on functionalized carbon nanotubes.

           PhD Thesis, 2020.  (Research adviser: B. Lemli)

  • Abdelilah Asserghine: Microelectrochemical characterization titanium biomaterials by scanning electrochemical microscopy,

           PhD Thesis, 2020. (Research advisers: G. Nagy and L. Nagy)

Prof. Dr. Kollár László
Kutatócsoport Vezető
 (36) 72 / 503-600 / 24153