A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
Kísérletes neurotraumatológia:
Kutatócsoportunk a koponyasérülések kísérletes vizsgálatát két standardizált, nemzetközileg széleskörűen alkalmazott/elismert állatkísérletes modell segítségével végzi: 1. Az ún. Marmarou-féle súly ejtéses vagy impakt akcelerációs koponyasérülés modell, mely elsősorban a zárt koponyasérülések esetén keletkező diffúz károsodások modellezésére szolgál illetve 2. az ún. folyadék perkussziós modell, mely elsősorban fokális sérülések tanulmányozására ad lehetőséget a központi idegrendszer különböző területein. A transzlációs szemlélettel végzett vizsgálataink (szövettani, magatartás élettani, biomarker és képalkotó vizsgálatok) fókuszpontjában az enyhe/ismétlődő enyhe koponyasérülések következményeinek felderítése áll.
Koponyasérültekkel kapcsolatos klinikai vizsgálatok:
Az ún. CENTER-TBI (“Collaborative European NeuroTrauma Effectiveness Research in TBI”) elnevezésű Európai Úniós (FP7 finanszírozott) project szérum biobankjának üzemeltetése, protein biomarker molekulák mérése (több, mint 3500 koponyasérült szérum mintái közel 60 különböző európai vizsgálóhelyről). A 2002 nyarán megkezdett “Pécsi Súlyos Koponyasérült Adatbázis” – mely több, mint 700 a Pécsi Tudományegyetem Idegsebészeti klinikáján kezelt súlyos koponyasérült klinikai adatait tartalmazza – gondozása, illetve az adatok több különböző célzatú statisztikai elemzése, publikálása.
Prémusz V, Lendvai-Emmert D, Makai A, Amrein K, Chauhan S, Bódis J, Kovács KA, Várnagy Á. Pre-Treatment Physical Activity Could Positively Influence Pregnancy Rates in IVF despite the Induced Oxidative Stress: A Cohort Study on Salivary 8-Hydroxy-2'-deoxyguanosine. Antioxidants (Basel). 2022 Aug 16;11(8):1586. doi: 10.3390/antiox11081586.
Lendvai-Emmert D, Emmert V, Makai A, Fusz K, Prémusz V, Eklics K, Sarlós P, Tóth P, Amrein K, Tóth G. Fecal calprotectin levels in pediatric cow's milk protein allergy. Front Pediatr. 2022 Aug 9;10:945212. doi: 10.3389/fped.2022.945212.
Nyul-Toth A, Fulop GA, Tarantini S, Kiss T, Ahire C, Faakye JA, Ungvari A, Toth P, Toth A, Csiszar A, Ungvari Z. Cerebral venous congestion exacerbates cerebral microhemorrhages in mice. Geroscience. 2022 Apr;44(2):805-816. doi: 10.1007/s11357-021-00504-0.
Richter S, Winzeck S, Czeiter E, Amrein K, Kornaropoulos EN, Verheyden J, Sugar G, Yang Z, Wang K, Maas AIR, Steyerberg E, Büki A, Newcombe VFJ, Menon DK; Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Sub-study Participants and Investigators. Serum biomarkers identify critically ill traumatic brain injury patients for MRI. Crit Care. 2022 Nov 29;26(1):369. doi: 10.1186/s13054-022-04250-3.
Maas AIR, Menon DK, Manley GT, Abrams M, Åkerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, Büki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey É, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao G, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikolić A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Orešič M, Peul W, Pisică D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, Røe C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vyvere TV, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R; InTBIR Participants and Investigators. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022 Nov;21(11):1004-1060. doi: 10.1016/S1474-4422(22)00309-X.
Helmrich IRAR, Czeiter E, Amrein K, Büki A, Lingsma HF, Menon DK, Mondello S, Steyerberg EW, von Steinbüchel N, Wang KKW, Wilson L, Xu H, Yang Z, van Klaveren D, Maas AIR; CENTER-TBI participants and investigators. Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study. Lancet Neurol. 2022 Sep;21(9):792-802. doi: 10.1016/S1474-4422(22)00218-6.
Toth L, Czigler A, Hegedus E, Komaromy H, Amrein K, Czeiter E, Yabluchanskiy A, Koller A, Orsi G, Perlaki G, Schwarcz A, Buki A, Ungvari Z, Toth PJ. Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults. Geroscience. 2022 Dec;44(6):2771-2783. doi: 10.1007/s11357-022-00623-2.
Mondello S, Sandner V, Goli M, Czeiter E, Amrein K, Kochanek PM, Gautam S, Cho BG, Morgan R, Nehme A, Fiumara G, Eid AH, Barsa C, Haidar MA, Buki A, Kobeissy FH, Mechref Y. Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study. EClinicalMedicine. 2022 Jun 17;50:101494. doi: 10.1016/j.eclinm.2022.101494.
Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, Kråkström M, Retel Helmrich IRA, Wang KKW, Maas AIR, Steyerberg EW, Menon DK, Tenovuo O, Hyötyläinen T, Büki A, Orešič M; CENTER-TBI Participants and Investigators. Serum metabolome associated with severity of acute traumatic brain injury. Nat Commun. 2022 May 10;13(1):2545. doi: 10.1038/s41467-022-30227-5.
Theakstone AG, Brennan PM, Ashton K, Czeiter E, Jenkinson MD, Syed K, Reed MJ, Baker MJ; CENTER-TBI Participants and Investigators. Vibrational Spectroscopy for the Triage of Traumatic Brain Injury Computed Tomography Priority and Hospital Admissions. J Neurotrauma. 2022 Jun;39(11-12):773-783. doi: 10.1089/neu.2021.0410.
Whitehouse DP, Vile AR, Adatia K, Herlekar R, Roy AS, Mondello S, Czeiter E, Amrein K, Büki A, Maas AIR, Menon DK, Newcombe VFJ. Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review. Neurosurgery. 2022 Feb 1;90(2):170-179. doi: 10.1227/NEU.0000000000001776.
Whitehouse DP, Monteiro M, Czeiter E, Vyvere TV, Valerio F, Ye Z, Amrein K, Kamnitsas K, Xu H, Yang Z, Verheyden J, Das T, Kornaropoulos EN, Steyerberg E, Maas AIR, Wang KKW, Büki A, Glocker B, Menon DK, Newcombe VFJ; CENTER-TBI Participants and Investigators. Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study. EBioMedicine. 2022 Jan;75:103777. doi: 10.1016/j.ebiom.2021.103777.
Tamás V, Büki A, Herold R. Mentalizációs deficit traumás agysérült betegek körében [Mentalizing deficit among patients with traumatic brain injury]. Ideggyogy Sz. 2021 Sep 30;74(9-10):295-307. doi: 10.18071/isz.74.0295.
Tamás V, Sebestyén G, Nagy SA, Horváth PZ, Mérei Á, Tomaiuolo F, Raffa G, Germanó AF, Büki A. Provocation and prediction of visual peripersonal neglect-like symptoms in preoperative planning and during awake brain surgery. Acta Neurochir (Wien). 2021 Jul;163(7):1941-1947. doi: 10.1007/s00701-021-04822-2.
Szenasi A, Amrein K, Czeiter E, Szarka N, Toth P, Koller A. Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation. Int J Mol Sci. 2021 Jun 21;22(12):6624. doi: 10.3390/ijms22126624.
Szarka N, Szellar D, Kiss S, Farkas N, Szakacs Z, Czigler A, Ungvari Z, Hegyi P, Buki A, Toth P. Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review. J Neurotrauma. 2021 Jun 1;38(11):1467-1483. doi: 10.1089/neu.2020.7265.
Schranz D, Molnar T, Erdo-Bonyar S, Simon D, Berki T, Nagy C, Czeiter E, Buki A, Lenzser G, Csecsei P. Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage. Acta Neurol Scand. 2021 May;143(5):530-537. doi: 10.1111/ane.13394.
Mondello S, Sorinola A, Czeiter E, Vámos Z, Amrein K, Synnot A, Donoghue E, Sándor J, Wang KKW, Diaz-Arrastia R, Steyerberg EW, Menon DK, Maas AIR, Buki A. Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis. J Neurotrauma. 2021 Apr 15;38(8):1086-1106. doi: 10.1089/neu.2017.5182.
Czigler A, Calviello LA, Zeiler FA, Toth P, Smielewski P, Czosnyka M. Usability of Noninvasive Counterparts of Traditional Autoregulation Indices in Traumatic Brain Injury. Acta Neurochir Suppl. 2021;131:163-166. doi: 10.1007/978-3-030-59436-7_33.
Czigler A, Fedriga M, Beqiri E, Lalou AD, Calviello LA, Cabeleira M, Toth P, Smielewski P, Czosnyka M. Errors and Consequences of Inaccurate Estimation of Mean Blood Flow Velocity in Cerebral Arteries. Acta Neurochir Suppl. 2021;131:23-25. doi: 10.1007/978-3-030-59436-7_5.
Nyúl-Tóth Á, Tarantini S, Kiss T, Toth P, Galvan V, Tarantini A, Yabluchanskiy A, Csiszar A, Ungvari Z. Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease. Geroscience. 2020 Dec;42(6):1685-1698. doi: 10.1007/s11357-020-00256-3.
Czeiter E, Amrein K, Gravesteijn BY, Lecky F, Menon DK, Mondello S, Newcombe VFJ, Richter S, Steyerberg EW, Vyvere TV, Verheyden J, Xu H, Yang Z, Maas AIR, Wang KKW, Büki A; CENTER-TBI Participants and Investigators. Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study. EBioMedicine. 2020 Jun;56:102785. doi: 10.1016/j.ebiom.2020.102785.
Mondello S, Guedes VA, Lai C, Czeiter E, Amrein K, Kobeissy F, Mechref Y, Jeromin A, Mithani S, Martin C, Wagner CL, Czigler A, Tóth L, Fazekas B, Buki A, Gill J. Circulating Brain Injury Exosomal Proteins following Moderate-To-Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications. Cells. 2020 Apr 15;9(4):977. doi: 10.3390/cells9040977.
Tadepalli SA, Bali ZK, Bruszt N, Nagy LV, Amrein K, Fazekas B, Büki A, Czeiter E, Hernádi I. Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats. Behav Brain Res. 2020 Jan 27;378:112268. doi: 10.1016/j.bbr.2019.112268.
Steyerberg EW, Wiegers E, Sewalt C, Buki A, Citerio G, De Keyser V, Ercole A, Kunzmann K, Lanyon L, Lecky F, Lingsma H, Manley G, Nelson D, Peul W, Stocchetti N, von Steinbüchel N, Vande Vyvere T, Verheyden J, Wilson L, Maas AIR, Menon DK; CENTER-TBI Participants and Investigators. Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurol. 2019 Oct;18(10):923-934. doi: 10.1016/S1474-4422(19)30232-7.
Czigler A, Toth L, Szarka N, Berta G, Amrein K, Czeiter E, Lendvai-Emmert D, Bodo K, Tarantini S, Koller A, Ungvari Z, Buki A, Toth P. Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31. J Neurotrauma. 2019 Dec 1;36(23):3309-3315. doi: 10.1089/neu.2019.6439.
Tóth A, Berente Z, Bogner P, Környei B, Balogh B, Czeiter E, Amrein K, Dóczi T, Büki A, Schwarcz A. Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging: A Rat Study. J Neurotrauma. 2019 May 15;36(10):1670-1677. doi: 10.1089/neu.2018.6004.
Tamás V, Kocsor F, Gyuris P, Kovács N, Czeiter E, Büki A. The Young Male Syndrome-An Analysis of Sex, Age, Risk Taking and Mortality in Patients With Severe Traumatic Brain Injuries. Front Neurol. 2019 Apr 12;10:366. doi: 10.3389/fneur.2019.00366.
Szarka N, Toth L, Czigler A, Kellermayer Z, Ungvari Z, Amrein K, Czeiter E, Bali ZK, Tadepalli SA, Wahr M, Hernadi I, Koller A, Buki A, Toth P. Single Mild Traumatic Brain Injury Induces Persistent Disruption of the Blood-Brain Barrier, Neuroinflammation and Cognitive Decline in Hypertensive Rats. Int J Mol Sci. 2019 Jun 30;20(13):3223. doi: 10.3390/ijms20133223.
Sorinola A, Buki A, Sandor J, Czeiter E. Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies. Front Neurol. 2019 Mar 15;10:226. doi: 10.3389/fneur.2019.00226.
Bazarian JJ, Biberthaler P, Welch RD, Lewis LM, Barzo P, Bogner-Flatz V, Gunnar Brolinson P, Büki A, Chen JY, Christenson RH, Hack D, Huff JS, Johar S, Jordan JD, Leidel BA, Lindner T, Ludington E, Okonkwo DO, Ornato J, Peacock WF, Schmidt K, Tyndall JA, Vossough A, Jagoda AS. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. Lancet Neurol. 2018 Sep;17(9):782-789. doi: 10.1016/S1474-4422(18)30231-X.
Szarka N, Pabbidi MR, Amrein K, Czeiter E, Berta G, Pohoczky K, Helyes Z, Ungvari Z, Koller A, Buki A, Toth P. Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2 and TRPV4-Dependent Activation of BKca Channels. J Neurotrauma. 2018 Apr 1;35(7):930-939. doi: 10.1089/neu.2017.5056.
Sorinola A, Buki A, Sandor J, Czeiter E. Effectiveness of Traumatic Brain Injury Management Guideline Introduction in Hungary. Turk Neurosurg. 2018;28(3):410-415. doi: 10.5137/1019-5149.JTN.19396-16.1.
Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Büki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao G, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Söderberg J, Stanworth SJ, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Te Ao B, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K; InTBIR Participants and Investigators. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec;16(12):987-1048. doi: 10.1016/S1474-4422(17)30371-X.
Maegele M, Schöchl H, Menovsky T, Maréchal H, Marklund N, Buki A, Stanworth S. Coagulopathy and haemorrhagic progression in traumatic brain injury: advances in mechanisms, diagnosis, and management. Lancet Neurol. 2017 Aug;16(8):630-647. doi: 10.1016/S1474-4422(17)30197-7.
Thelin EP, Zeiler FA, Ercole A, Mondello S, Büki A, Bellander BM, Helmy A, Menon DK, Nelson DW. Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review. Front Neurol. 2017 Jul 3;8:300. doi: 10.3389/fneur.2017.00300.
Szarka N, Amrein K, Horvath P, Ivic I, Czeiter E, Buki A, Koller A, Toth P. Hypertension-Induced Enhanced Myogenic Constriction of Cerebral Arteries Is Preserved after Traumatic Brain Injury. J Neurotrauma. 2017 Jul 15;34(14):2315-2319. doi: 10.1089/neu.2016.4962.
Tamás V, Kovács N, Büki A. A sportolás és a baleseti agysérülés összefüggései - veszélyek és következmények. Ideggyogy Sz. 2017 Mar 30;70(3-4):89-96. Hungarian. doi: 10.18071/isz.70.0089.
Toth P, Szarka N, Farkas E, Ezer E, Czeiter E, Amrein K, Ungvari Z, Hartings JA, Buki A, Koller A. Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1118-H1131. doi: 10.1152/ajpheart.00267.2016.
Nemes O, Kovacs N, Szujo S, Bodis B, Bajnok L, Buki A, Doczi T, Czeiter E, Mezosi E. Can early clinical parameters predict post-traumatic pituitary dysfunction in severe traumatic brain injury? Acta Neurochir (Wien). 2016 Dec;158(12):2347-2353. doi: 10.1007/s00701-016-2995-x.
Buki A, Kovacs N, Czeiter E, Schmid K, Berger RP, Kobeissy F, Italiano D, Hayes RL, Tortella FC, Mezosi E, Schwarcz A, Toth A, Nemes O, Mondello S. Minor and repetitive head injury. Adv Tech Stand Neurosurg. 2015;42:147-92. doi: 10.1007/978-3-319-09066-5_8.
Bukovics P, Czeiter E, Amrein K, Kovacs N, Pal J, Tamas A, Bagoly T, Helyes Z, Buki A, Reglodi D. Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury. Peptides. 2014 Oct;60:18-22. doi: 10.1016/j.peptides.2014.07.001.
