About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Translational neuroscience research group

  • Research concept
  • Members
  • R and D results
  • Services
  • Laboratories, instruments
  • Galleries
  • In vivo cellular laboratory: extracellular unit recording, stereotaxic apparaus, biollogical signal conditioning (amplifiers,filters, ADCs, measurement of voltage and current), constant current ganerators (for microiontophoresis).
  • Small animal behavior laboratory: general activity, open field test, elevated plus maze test, forced swim test, food-choice tests, computer controlled operant behavioral chambers, neurotoxic brain lesions, reversible brain inactivation, central/systemic administration of bioactive agents.
  • Human psychophysiology laboratory: high performance 32 channel biological amplifier (EEG, EMG, ECG, EOG), computer controlled behavioral apparatus. Current research 1) basic: neurophysiology of face perception; 2) applied: neurocognitve effects of non-ionising environmental electromagnetic fields.

 

http://www.neurobio.pte.hu/kutatas/index.html

  • Development of tools and equipment for microelectrophysiology (from 1995).
  • Microelectrode development and testing (from 2000)
  • Software development for electrophysiology (from 2006)
  • Behavioral testing apparatus for measurement of thermal pain threshold (2007-2009)

Applied systems neuroscience, drug development and validation

  • Development of novel testing techniques and methodology.
  • Development of novel equipment for testing.
  • Neurophysiological testing of bioactive environmental (chemical and electromagnetc) agents.
  • Research and development and formal education within the scope of the laboratory.

The Translational Neuroscience Research Group was establish by István Hernádi, PhD in 2014 at the University of Pécs. The research group develops preclinical models of neurocognitive disorders in four laboratories:

1. Small animal behavioural pharmacology laboratory at the Szentágothai János Research Centre

2. Electrophysiology laboratory at the Faculty of Sciences

3. NHP laboratory at the Grastyán Endre Translational Research Centre

4. Human psychophysiology laboratory at the Faculty of Sciences

The research group is dedicated to basic and applied research in systems neuroscience. We aim to adopt and further develop in vivo animal and human models of higher order mammalian brain function with special emphasis on searching functional biomarkers of pathological mechanisms related to neurodegenerative brain disorders, esp. Alzheimer's disease, schizophrenia and developmental spectrum disorders. The four laboratories provide a unique repertoire of technical tools for targeting multidisciplinary research within the same research group. Our main objective is to support the need of parallel comprehensive testing of novel drug-candidates against cognitive impairment in in vivo preclinical animal experiments and human studies.