A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The research field of the team is the developmental biology of murine lymphoid tissues involved in immune defence, addressing the roles of hematopoietic and stromal constituents. We have produced several rat monoclonal antibodies against the cellular and matrix components of mesenchymal scaffolding, for evaluating the roles of various morphogenic factors (DNA-binding proteins and cytokines) guiding the development of spleen and intestinal lymphoid tissues in animal experimentations by using transgenic models and in vivo immunomodulatory approaches. In this work, we have identified hitherto unknown lymphoid tissue components and novel forms of lymphoid tissues, which may play important roles in the regulation of peritoneal lymphocyte distribution and progression of lymphoid malignancies.
Our R&D activities cover the analysis of immunomodulatory agents affecting the structure, composition and immunological functions of lymphoid organs, and the development of tumor models; recently we have initiated recombinant antibody development. The service portfolio includes the development of monoclonal antibodies (rat and mouse), immunochemical procedures (antibody purification and downstream processing, labelling [fluorochromes, biotin, HRPO], QC), fluorescence, immunohistochemical and serological kit development and lymphoid tissue analysis, cell sorting (fluorescent and magnetic), establishment of hematopoietic chimeras using MHC and Thy-1 allotype as well as fluoroprotein tracing, and in vivo motility analysis using Kikume photoconversion.
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Role of adipose-associated lymphoid tissues in the immunological homeostasis of the serosal surface. Jia X, Berta G, Gábris F, Kellermayer Z, Balogh P. Immunol Lett. 2020 Dec;228:135-141. doi: 10.1016/j.imlet.2020.11.001. Epub 2020 Nov 6. PMID: 33166529 Review. |
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Jia X, Gábris F, Jacobsen Ó, Bedics G, Botz B, Helyes Z, Kellermayer Z, Vojkovics D, Berta G, Nagy N, Jakus Z, Balogh P. J Immunol. 2020 Jan 1;204(1):23-36. doi: 10.4049/jimmunol.1900851. Epub 2019 Nov 25. PMID: 31767783 |
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Vojkovics D, Kellermayer Z, Gábris F, Schippers A, Wagner N, Berta G, Farkas K, Balogh P. Front Immunol. 2019 Mar 5;10:366. doi: 10.3389/fimmu.2019.00366. eCollection 2019. PMID: 30891037 Free PMC article. |
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IL-22-Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice. Kellermayer Z, Vojkovics D, Dakah TA, Bodó K, Botz B, Helyes Z, Berta G, Kajtár B, Schippers A, Wagner N, Scotto L, O'Connor OA, Arnold HH, Balogh P. J Immunol. 2019 Mar 15;202(6):1833-1844. doi: 10.4049/jimmunol.1801117. Epub 2019 Jan 30. PMID: 30700585 |
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Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies. Vojkovics D, Kellermayer Z, Kajtár B, Roncador G, Vincze Á, Balogh P. Biomark Insights. 2018 Feb 6;13:1177271918757480. doi: 10.1177/1177271918757480. eCollection 2018. PMID: 29449776 Free PMC article. Review. |
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Innate lymphoid cells and their stromal microenvironments. Kellermayer Z, Vojkovics D, Balogh P. Immunol Lett. 2017 Sep;189:3-9. doi: 10.1016/j.imlet.2017.04.008. Epub 2017 Apr 13. PMID: 28414182 Review. |
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Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA. Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889. PMID: 27297662 Free PMC article. |
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Vojkovics D, Kellermayer Z, Heidt D, Mihalj M, Kajtár B, Ernszt D, Kovács T, Németh P, Balogh P. Pathol Oncol Res. 2016 Apr;22(2):421-30. doi: 10.1007/s12253-015-0025-6. Epub 2015 Nov 19. PMID: 26584567 |
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Kellermayer Z, Hayasaka H, Kajtár B, Simon D, Robles EF, Martinez-Climent JA, Balogh P. Int Rev Immunol. 2016 Nov;35(6):489-502. doi: 10.3109/08830185.2015.1059427. Epub 2015 Jul 17. PMID: 26186200 Review. |
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Kellermayer Z, Mihalj M, Lábadi Á, Czömpöly T, Lee M, O'Hara E, Butcher EC, Berta G, Balogh A, Arnold HH, Balogh P. J Immunol. 2014 Nov 15;193(10):5284-93. doi: 10.4049/jimmunol.1402016. Epub 2014 Oct 15. PMID: 25320278 |
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Kellermayer Z, Fisi V, Mihalj M, Berta G, Kóbor J, Balogh P. J Histochem Cytochem. 2014 Jun;62(6):436-449. doi: 10.1369/0022155414529595. Epub 2014 Mar 26. PMID: 24670793 Free PMC article. |
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Mihalj M, Kellermayer Z, Balogh P. Int Immunol. 2013 Jul;25(7):423-35. doi: 10.1093/intimm/dxt001. Epub 2013 Feb 28. PMID: 23449667 |
IBL rat monoclonal antibody series
Developmental Biology of Peripheral Lymphoid Organs
Biotechnology
