A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The research area of this team is developmental biology of murine lymphoid tissues involved in immune defense and the roles of hematopoietic and stromal constituents. The team has produced several rat monoclonal antibodies against the cellular and matrix components of mesenchymal scaffolding, which proved informative in evaluating the roles of various morphogenetic factors (DNA-binding proteins and cytokines). Additionally, the team utilized transgenic models and in vivo immunomodulatory approaches to influence the development of spleen and intestinal lymphoid tissues in animal experimentation. As a result, the group has identified previously unrecognized lymphoid tissue components and novel forms of lymphoid tissues that may play a significant role in the regulation of peritoneal lymphocyte distribution and the progression of lymphoid malignancies. The research and development activities include the analysis of the structure, composition, and immunological functions of lymphoid organs, as well as the development of tumor models. We have recently commenced the development of recombinant antibodies. The service portfolio encompasses the development of monoclonal antibodies (rat and mouse), immunochemical procedures (antibody purification and downstream processing, labelling [fluorochromes, biotin, HRPO], QC), and multiple immunofluorescence. The group has also engaged in the development of immunohistochemical and serological kits and cell sorting procedures utilising both fluorescent and magnetic techniques. Furthermore, they have established hematopoietic chimeras employing MHC and Thy-1 allotypes, fluoroprotein tracing, and have conducted in vivo mobility analyses using Kikume photoconversion.
Absence of Nkx2-3 induces ectopic lymphatic endothelial differentiation associated with impaired extramedullary stress hematopoiesis in the spleen. Gábris, F., Kiss, G., Szirmay, B., Szomor, Á., Berta, G., Jakus, Z., Kellermayer, Z., Balogh, P. (2023) Frontiers in Cell and Developmental Biology 11: 1170389. PMID: 37091975 DOI: 10.3389/fcell.2023.1170389
Age-Associated B Cell Features of the Murine High-Grade B Cell Lymphoma Bc.DLFL1 and Its Extranodal Expansion in Abdominal Adipose Tissues. Jia, X., Bene, J., Balázs, N., Szabó, K., Berta, G., Herczeg, R., Gyenesei, A., Balogh, P. (2022). The Journal of Immunology 208: 2866-2876. PMID: 35867673 DOI: 10.4049/jimmunol.2100956
Foliate Lymphoid Aggregates as Novel Forms of Serous Lymphocyte Entry Sites of Peritoneal B Cells and High-Grade B Cell Lymphomas. Jia, X., Gábris, F., Jacobsen, O., Bedics, G., Botz, B., Helyes, Zs., Kellermayer, Z., Vojkovics, D., Berta, G., Nagy, N., Jakus, Z., Balogh, P. (2020) The Journal of Immunology 204: 23. PMID: 31767783 DOI: 10.4049/jimmunol.1900851
Role of adipose-associated lymphoid tissues in the immunological homeostasis of the serosal surface. Jia X, Berta G, Gábris F, Kellermayer Z, Balogh P. Immunol Lett. 2020 Dec;228:135-141. doi: 10.1016/j.imlet.2020.11.001. Epub 2020 Nov 6. PMID: 33166529 Review.
Foliate Lymphoid Aggregates as Novel Forms of Serous Lymphocyte Entry Sites of Peritoneal B Cells and High-Grade B Cell Lymphomas. Jia X, Gábris F, Jacobsen Ó, Bedics G, Botz B, Helyes Z, Kellermayer Z, Vojkovics D, Berta G, Nagy N, Jakus Z, Balogh P.J Immunol. 2020 Jan 1;204(1):23-36. doi:10.4049/jimmunol.1900851. Epub 2019 Nov 25. PMID: 31767783
IL-22-Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice. Kellermayer, Z., Vojkovics, D., Dakah, TA., Bodó, K., Botz, B., Helyes, Zs., Berta, G., Kajtár, B., Schippers, A., Wagner, N., Scotto, L., O’Connor, OA., Arnold, H., Balogh, P. (2019) The Journal of Immunology 202: 1833. PMID: 30700585 DOI: 10.4049/jimmunol.1801117
Differential Effects of the Absence of Nkx2-3 and MAdCAM-1 on the Distribution of Intestinal Type 3 Innate Lymphoid Cells and Postnatal SILT Formation in Mice. Vojkovics D, Kellermayer Z, Gábris F, Schippers A, Wagner N, Berta G, Farkas K, Balogh P. Front Immunol. 2019 Mar 5;10:366. doi: 10.3389/fimmu.2019.00366. eCollection 2019. PMID: 30891037 Free PMC article.
IL-22-Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice. Kellermayer Z, Vojkovics D, Dakah TA, Bodó K, Botz B, Helyes Z, Berta G, Kajtár B, Schippers A, Wagner N, Scotto L, O'Connor OA, Arnold HH, Balogh P. J Immunol. 2019 Mar 15;202(6):1833-1844. doi: 10.4049/jimmunol.1801117. Epub 2019 Jan 30. PMID: 30700585
Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies. Vojkovics D, Kellermayer Z, Kajtár B, Roncador G, Vincze Á, Balogh P. Biomark Insights. 2018 Feb 6;13:1177271918757480. doi: 10.1177/1177271918757480. eCollection 2018.PMID: 29449776 Free PMC article. Review.
Innate lymphoid cells and their stromal microenvironments. Kellermayer Z, Vojkovics D, Balogh P. Immunol Lett. 2017 Sep;189:3-9. doi: 10.1016/j.imlet.2017.04.008. Epub 2017 Apr 13. PMID: 28414182 Review.
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA. Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889. PMID: 27297662 Free PMC article.
Isolation and Characterization of a Murine Spontaneous High-Grade Follicular Lymphoma with Restricted In Vivo Spreading--a Model for Lymphatic Metastasis Via the Mesentery. Vojkovics D, Kellermayer Z, Heidt D, Mihalj M, Kajtár B, Ernszt D, Kovács T, Németh P, Balogh P.Pathol Oncol Res. 2016 Apr;22(2):421-30. doi: 10.1007/s12253-015-0025-6. Epub 2015 Nov 19.PMID: 26584567
Divergence of Vascular Specification in Visceral Lymphoid Organs-Genetic Determinants and Differentiation Checkpoints. Kellermayer Z, Hayasaka H, Kajtár B, Simon D, Robles EF, Martinez-Climent JA, Balogh P. Int Rev Immunol. 2016 Nov;35(6):489-502. doi: 10.3109/08830185.2015.1059427. Epub 2015 Jul 17. PMID: 26186200 Review.
Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches. Kellermayer Z, Mihalj M, Lábadi Á, Czömpöly T, Lee M, O'Hara E, Butcher EC, Berta G, Balogh A, Arnold HH, Balogh P.nJ Immunol. 2014 Nov 15;193(10):5284-93. doi: 10.4049/jimmunol.1402016. Epub 2014 Oct 15. PMID: 2532027811.
Marginal Zone Macrophage Receptor MARCO Is Trapped in Conduits Formed by Follicular Dendritic Cells in the Spleen. Kellermayer Z, Fisi V, Mihalj M, Berta G, Kóbor J, Balogh P. J Histochem Cytochem. 2014 Jun;62(6):436-449. doi: 10.1369/0022155414529595. Epub 2014 Mar 26. PMID: 24670793 Free PMC article.
Follicles in gut-associated lymphoid tissues create preferential survival niches for follicular Th cells escaping Thy-1-specific depletion in mice. Mihalj M, Kellermayer Z, Balogh P. Int Immunol. 2013 Jul;25(7):423-35. doi: 10.1093/intimm/dxt001. Epub 2013 Feb 28. PMID: 23449667
IBL rat monoclonal antibody series
Developmental Biology of Peripheral Lymphoid Organs
Biotechnology
