About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...



This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.


Lymphoid Organ Research Group

  • Research concept
  • Members
  • Publications
  • R and D results
  • Services
  • Laboratories, instruments
  • Galéria

The research field of the team is the developmental biology of murine lymphoid tissues involved in immune defence, addressing the roles of hematopoietic and stromal constituents. We have produced several rat monoclonal antibodies against the cellular and matrix components of mesenchymal scaffolding, for evaluating the roles of various morphogenic factors (DNA-binding proteins and cytokines) guiding the development of spleen and intestinal lymphoid tissues in animal experimentations by using transgenic models and in vivo immunomodulatory approaches. In this work, we have identified hitherto unknown lymphoid tissue components and novel forms of lymphoid tissues, which may play important roles in the regulation of peritoneal lymphocyte distribution and progression of lymphoid malignancies. 

Our R&D activities cover the analysis of immunomodulatory agents affecting the structure, composition and immunological functions of lymphoid organs, and the development of tumor models; recently we have initiated recombinant antibody development. The service portfolio includes the development of monoclonal antibodies (rat and mouse), immunochemical procedures (antibody purification and downstream processing, labelling [fluorochromes, biotin, HRPO], QC), fluorescence, immunohistochemical and serological kit development and lymphoid tissue analysis, cell sorting (fluorescent and magnetic), establishment of hematopoietic chimeras using MHC and Thy-1 allotype as well as fluoroprotein tracing, and in vivo motility analysis using Kikume photoconversion.

Dr. Zoltán Kellermayer
assistant professor

Dr. Árpád Lábadi
assistant lecturer

Dr. Gergely Talabér
PhD student

Selected publications



Role of adipose-associated lymphoid tissues in the immunological homeostasis of the serosal surface. 

Jia X, Berta G, Gábris F, Kellermayer Z, Balogh P.

Immunol Lett. 2020 Dec;228:135-141. doi: 10.1016/j.imlet.2020.11.001. Epub 2020 Nov 6.

PMID: 33166529 Review.


Foliate Lymphoid Aggregates as Novel Forms of Serous Lymphocyte Entry Sites of Peritoneal B Cells and High-Grade B Cell Lymphomas. 

Jia X, Gábris F, Jacobsen Ó, Bedics G, Botz B, Helyes Z, Kellermayer Z, Vojkovics D, Berta G, Nagy N, Jakus Z, Balogh P.

J Immunol. 2020 Jan 1;204(1):23-36. doi: 10.4049/jimmunol.1900851. Epub 2019 Nov 25.

PMID: 31767783


Differential Effects of the Absence of Nkx2-3 and MAdCAM-1 on the Distribution of Intestinal Type 3 Innate Lymphoid Cells and Postnatal SILT Formation in Mice. 

Vojkovics D, Kellermayer Z, Gábris F, Schippers A, Wagner N, Berta G, Farkas K, Balogh P.

Front Immunol. 2019 Mar 5;10:366. doi: 10.3389/fimmu.2019.00366. eCollection 2019.

PMID: 30891037 Free PMC article.


IL-22-Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice. 

Kellermayer Z, Vojkovics D, Dakah TA, Bodó K, Botz B, Helyes Z, Berta G, Kajtár B, Schippers A, Wagner N, Scotto L, O'Connor OA, Arnold HH, Balogh P.

J Immunol. 2019 Mar 15;202(6):1833-1844. doi: 10.4049/jimmunol.1801117. Epub 2019 Jan 30.

PMID: 30700585


Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies. 

Vojkovics D, Kellermayer Z, Kajtár B, Roncador G, Vincze Á, Balogh P.

Biomark Insights. 2018 Feb 6;13:1177271918757480. doi: 10.1177/1177271918757480. eCollection 2018.

PMID: 29449776 Free PMC article. Review.


Innate lymphoid cells and their stromal microenvironments. 

Kellermayer Z, Vojkovics D, Balogh P.

Immunol Lett. 2017 Sep;189:3-9. doi: 10.1016/j.imlet.2017.04.008. Epub 2017 Apr 13.

PMID: 28414182 Review.


Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. 

Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA.

Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889.

PMID: 27297662 Free PMC article.


Isolation and Characterization of a Murine Spontaneous High-Grade Follicular Lymphoma with Restricted In Vivo Spreading--a Model for Lymphatic Metastasis Via the Mesentery. 

Vojkovics D, Kellermayer Z, Heidt D, Mihalj M, Kajtár B, Ernszt D, Kovács T, Németh P, Balogh P.

Pathol Oncol Res. 2016 Apr;22(2):421-30. doi: 10.1007/s12253-015-0025-6. Epub 2015 Nov 19.

PMID: 26584567


Divergence of Vascular Specification in Visceral Lymphoid Organs-Genetic Determinants and Differentiation Checkpoints. 

Kellermayer Z, Hayasaka H, Kajtár B, Simon D, Robles EF, Martinez-Climent JA, Balogh P.

Int Rev Immunol. 2016 Nov;35(6):489-502. doi: 10.3109/08830185.2015.1059427. Epub 2015 Jul 17.

PMID: 26186200 Review.


Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches. 

Kellermayer Z, Mihalj M, Lábadi Á, Czömpöly T, Lee M, O'Hara E, Butcher EC, Berta G, Balogh A, Arnold HH, Balogh P.

J Immunol. 2014 Nov 15;193(10):5284-93. doi: 10.4049/jimmunol.1402016. Epub 2014 Oct 15.

PMID: 25320278


Marginal Zone Macrophage Receptor MARCO Is Trapped in Conduits Formed by Follicular Dendritic Cells in the Spleen. 

Kellermayer Z, Fisi V, Mihalj M, Berta G, Kóbor J, Balogh P.

J Histochem Cytochem. 2014 Jun;62(6):436-449. doi: 10.1369/0022155414529595. Epub 2014 Mar 26.

PMID: 24670793 Free PMC article.


Follicles in gut-associated lymphoid tissues create preferential survival niches for follicular Th cells escaping Thy-1-specific depletion in mice. 

Mihalj M, Kellermayer Z, Balogh P.

Int Immunol. 2013 Jul;25(7):423-35. doi: 10.1093/intimm/dxt001. Epub 2013 Feb 28.

PMID: 23449667

IBL rat monoclonal antibody series

Developmental Biology of Peripheral Lymphoid Organs


  • Production and characterization of monoclonal antibodies in cellular and molecular immune assays
  • Phenotypic analysis of human and mouse lymphoid cells, establishment and characterization of chimeric and transgenic animals.
  • Tissue culture laboratory
  • immunoserology equipment
  • multiparameter flow cytometry
  • fluorescence microscopy

Lymphoid organ research group

Prof. Dr. Péter Balogh
Research Group Leader
 +36 72 536001 /36524