The Malvern Panalytical NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization, especially size characterization of extracellular vesicles. Particles in liquid suspension are loaded into a sample chamber. In the path of the beam the particles scatter the laser light which is easily collected by the microscope objective and is viewed with a digital camera. The camera captures a video of the particles moving under Brownian motion. The NS300 allows rapid analysis of the size distribution and concentration of all types of nanoparticles from 10 nm - 2 µm in diameter, depending on the instrument configuration and sample type. With the ability to be supplied with interchangeable laser modules and the introduction of a motorized filter wheel means different fluorescent labels can be analyzed.
Detectable particle size: 10nm - 2000nm
Lasers: 488nm (Blue), 532nm (Green)
Concentration: 109 particle / ml
NS300 can be applied in the development of different delivery system studies:
- Viral vaccine research
- Nano-toxicology and viral vaccine detection
- Protein aggregation studies
- Extracellular vesicle characterization in different stages of diseases
- Exosome and microvesicle characterization
