A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...
The research team's findings concentrate on the utilisation of innovative bioimpedance-based technologies. The research team has developed, verified, and validated in vitro measurement cells with different dedicated electrode architectures for spectroscopy and tomography applications. They have also identified, calibrated, and validated basic cell biological processes, including proliferation, apoptosis, necrosis, and hypertrophy. The use of bioimpedance measurements allows for the monitoring of the mechanisms of action of chemotherapy and non-alcoholic fatty liver disease (steatosis and fat accumulation) by in vitro bioimpedance spectroscopy. Furthermore, it enables the monitoring of the response of bacterial cultures to different treatments. Additionally, microfluidic systems can be used, with continuously optimized measurement set-ups, electrode configurations, and even routine experiments on different cell lines and mouse embryos. During the course of our activities, we will verify the manufacturing properties (in particular, reproducibility) and biocompatibility of our in vitro measuring cells. In the initial in vitro experiments utilizing HepG2 cell lines, we will monitor the development of steatosis and correlate the characteristics of fat accumulation with the parameters obtained from bioimpedance measurements. Moreover, the feasibility of maintaining bacterial cultures in our in vitro measuring cell in a manner that allows for routine bioimpedance monitoring will be explored.
Cooperating partners:
NWM Consult Kft.
University of Pécs, Medical School, Institute of Physiology
University of Pécs, Medical School, Department of Medical Microbiology and Immunology
University of Pécs, Faculty of Engineering and Information Tecnology, Symbolic Methods in Materials Testing and Tomography Research Group
HUN-REN Centre for Energy Research, Institute of Technical Physics and Materials Science, Microsystems Department
HUN-REN Institute of Molecular Life Sciences, Drug Resistance Research Group
Obuda University John von Neumann Faculty of Informatics
Obuda University University Research and Innovation Center
Zoltan Vizvari, Mihaly Klincsik, Peter Odry, Vladimir Tadic, Nina Gyorfi, Attila Toth, Zoltan Sari, Continuous Electrode Models and Application of Exact Schemes in Modeling of Electrical Impedance Measurements, ELECTRONICS 13, 66. (2025) https://doi.org/10.3390/electronics13010066
Vizvári Zoltán, Klincsik Mihály, Kersner Róbert, Odry Péter, Sári Zoltán, Tadić Vladimir, Axioms and Methods for Handling Differential Equations and Inverse Problems, AXIOMS 14, 692 (2025) https://doi.org/10.3390/axioms14090692
Kovács Flórián, Odry Ákos, Vizvári Zoltán, Szegő Anita, Chen Haimei, Papdi Enikő, Gyalai Ingrid Melinda, Kun Ágnes, Odry Péter, Juhos Katalin, Electrical bioimpedance spectroscopy as a tool for non-destructive monitoring nitrogen supply in two lettuce genotypes, Scientia Horticulturae
Vol. 349, 114229 (2025) https://doi.org/10.1016/j.scienta.2025.114229
Kovács Flórián, Juhos Katalin, Odry Ákos, Ladányi Márta, Papdi Enikő, Gyalai Ingrid Melinda, Simon Gergely, Gergely Mátyás, Süli Ágnes, Donyina Gideon Adu, Odry Péter, Vizvári Zoltán, Early detection of nitrogen status in cucumber plants using bioimpedance spectroscopy, Smart Agricultural Technology Vol.12, 101610 (2025) https://doi.org/10.1016/j.atech.2025.101610
Kovács Flórián, Juhos Katalin, Vizvári Zoltán, Odry Péter, Gyalai Ingrid M., Sarcevic Peter, Odry Ákos, Bioimpedance Analysis of Cucumber Plants Exposed to Different Nitrogen Doses Under Greenhouse Conditions, Sensors 25, 2486. (2025) https://doi.org/10.3390/s25082486
Kovács Flórián, Odry Ákos, Vizvári Zoltán, Kabalan Sundoss, Papdi Enikő, Odry Péter, Juhos Katalin, A novel approach to water stress assessment in plants: New bioimpedance method with PSO-optimized Cole-Cole impedance modeling, Computers and Electronics in Agriculture Vol. 234, 110167. (2025) https://doi.org/10.1016/j.compag.2025.110167
Bató Lilia, Fürjes Péter, Bozorádi János M., Tadić Vladimir, Odry Péter, Vízvári Zoltán, Sensitivity Analysis of Localized Electrochemical Impedance Spectroscopy Towards Tomography-on-a-Chip, Sensors 25, 6393. (2025) https://doi.org/10.3390/s25206393
Vizvari Zoltan, Klincsik Mihaly, Odry Peter, Tadic Vladimir, Gyorfi Nina, Toth Attila, Sari Zoltan, Continuous Electrode Models and Application of Exact Schemes in Modeling of Electrical Impedance Measurements, ELECTRONICS (SWITZ) 13 : 1 Paper: 66 , 17 p. (2023)
Gyorfi Nina, Gal Adrian R., Fincsur Andras, Kalmar-Nagy Karoly, Mintal Kitti, Hormay Edina, Miseta Attila, Tornoczky Tamas, Nemeth Anita K., Bogner Peter, Kiss Tamas, Helyes Zsuzsanna, Sari Zoltán, Klincsik Mihaly, Tadic Vladimir, Lenard Laszlo, Vereczkei Andras, Karádi Zoltán, Vizvári Zoltan, Toth Attila, Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases, BIOMEDICINES 11 : 9 Paper: 2449 , 21 p. (2023)
Vizvari Zoltan, Klincsik Mihaly, Odry Peter, Tadic Vladimir, Sari Zoltan, General Exact Schemes for Second-Order Linear Differential Equations Using the Concept of Local Green Functions, AXIOMS 12 : 7 Paper: 633 , 16 p. (2023)
Sari Zoltan, Klincsik Mihaly, Odry Peter, Tadic Vladimir, Toth Attila, Vízvári Zoltán, Lumped Element Method Based Conductivity Reconstruction Algorithm for Localization Using Symmetric Discrete Operators on Coarse Meshes, SYMMETRY (BASEL) 15 : 5 Paper: 1008 , 24 p. (2023)
Gyorfi Nina, Odry Akos, Karadi Zoltan, Odry Peter, Szakall Tibor, Kuljic Bojan, Toth Attila, Vizvári Zoltán, Development of Bioimpedance-based Measuring Systems for Diagnosis of Non-alcoholic Fatty Liver Disease, 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021, Budapest, Magyarország, Piscataway (NJ), Amerikai Egyesült Államok : Óbudai Egyetem, IEEE (2021) 539 p. pp. 135-140. , 6 p.
Nadasdi Lili, Maczko Gergo, Gyorfi Nina, Tenzlinger Kristof, Odry Akos, Odry Peter, Szechenyi Aleksandar, Karadi Zoltan, Pal Jozsef, Toth Attila, Vizvári Zoltán, Preparation and Validation of Self-developed Bioimpedance Electrode Array for Measurement of Tumor Cells, 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021, Budapest, Magyarország, Piscataway (NJ), Amerikai Egyesült Államok : Óbudai Egyetem, IEEE (2021) 539 p. pp. 000129-000134. , 6 p.
Toth Attila, Ruzsics Istvan, Helyes Zsuzsanna, Cseko Kata, Varga Janos, Fekete Andrea, Cserjesi Renata, Vizvári Zoltán, Investigation of a bioimpedance-based measurement method of diaphragmatic muscle movements during respiratory characteristics, 15th IEEE International Symposium on Applied Computational Intelligence and Informatics SACI 2021, Budapest, Magyarország, Piscataway (NJ), Amerikai Egyesült Államok : Óbudai Egyetem, IEEE (2021) 539 p. pp. 123-128. , 6 p.
Vizvari Zoltán, Győrfi Nina, Mintal Kitti, Karádi Zoltán, Tóth Attila, Sári Zoltán, Odry Péter, Eigner György, Kovács Levente, Léner Violetta, Hámori Lilla, Füredi András, Development of non-invasive, bioimpedance-based measuring device for primary tumor detection, 21th IEEE International Symposium on Computational Intelligence and Informatics (CINTI 2021), Piscataway (NJ), Amerikai Egyesült Államok : IEEE (2021) 273 p. pp. 205-210. , 6 p.
Vizvári Zoltán, Klincsik Mihály, Sári Zoltán, Odry Péter, Lumped Element Method: A Discrete Calculus Approach for Solving Elliptic and Parabolic PDEs, ACTA POLYTECHNICA HUNGARICA 18 : 7 pp. 201-223. , 23 p. (2021)
Vizvari Zoltan, Sari Zoltan, Klincsik Mihaly, Odry Peter, Exact schemes for second-order linear differential equations in self-adjoint cases, ADVANCES IN DIFFERENCE EQUATIONS 2020 : 1 Paper: 497, 16 p. (2020)
Vizvari Zoltan, Gyorfi Nina, Odry Akos, Sari Zoltan, Klincsik Mihaly, Gergics Marin, Kovacs Levente, Kovacs Anita, Pal Jozsef, Karadi Zoltan, Odry Peter, Tóth Attila, Physical Validation of a Residual Impedance Rejection Method during Ultra-Low Frequency Bio-Impedance Spectral Measurements, SENSORS 20 : 17 Paper: 4686 , 20 p. (2020)
Other publications:
Zoltán Ákos Vizvári, Development of mathematical and measurement methods for electrical impedance based techniques, Óbuda University, Doctoral School of Applied Informatics and Applied Mathematics, Péter Odry Year of submission of dissertation: 2022, Year of defence: 2022 Year of publication/PhD: 2022
Attila Tóth (Editor), Zoltán Vizvári (Editor), Biomedical questions - multidisciplinary, bioimpedance-based answers: a collection of publications of the PTE Metabolism and Bioimpedance Research Group, conference proceedings, Pécs, Hungary : University of Pécs (2022), ISBN: 9789634299349
2024:
Győrfi Nina, Impedance spectroscopy-based study of human carcinoma cells, University Research Grant Program EKÖP-24-1
2023:
Dr. Vizvári Zoltán Ákos, Development of new, in vitro, Lab-on-a-Chip bioimpedance measurement cells, 011_2023_PTE_RK/4
Dr. Tóth Attila, Bioimpedance-based characterization of NAFLD/NASH development, cellular characteristics for drug development, 009-2023-PTE-RK/27
Győrfi Nina, In vitro bioimpedance-based study of NAFLD, Academic support program
Previous projects:
Higher Education Institutional Excellence Programme (20765-3/2018/FEKUTSTRAT)
Thematic Excellence Programme 2019 (TUDFO/51757-1/2019-ITMA)
"Development of scientific workshops in the training of doctors, health sciences and pharmacists" (EFOP-3.6.3-VEKOP-16-2017-00009)
"Comprehensive developments at the University of Pécs for the implementation of smart specialisation" (EFOP-3.6.1-16-2016-2016-00004)
The activities of the research team are based on the following patented technologies:
PCT (i.e. international) application; application number PCT/HU2016/050062: the following regional/national stages of the application have been initiated:
EUROPEAN REGIONAL application; application number: EP1689383: according to the notification of the European Patent Office, the publication of the grant decision was published in the European Patent Bulletin on 17 June 2020
US application; application number 16/062,319: national patent granted on 30.06.2020, registration number 10,699,446.
JAPAN application; application number: 2018-531076: patent pending, Japanese patent No 6791966 granted on 09.11.2020.
CANADA application; application number 3,007,977: patent pending.
PTE-internal know-how application: assessment of obesity and fatty liver disease by bioimpedance measurement, 21.07.2017.
The activities of our research group are based on a self-developed bioimpedance (BI) measurement technology. An implementation of this technology is represented by the following instruments with the following characteristics and technical parameters:
The Research Group is located in the SzKK laboratory B216. The research team uses the following tools to carry out its research:
1 multigas incubator
1 biosafety cabinet
2 four-channel bioimpedance meters
1 manual bioimpedance meter
Student achievements and results:
Berner Enikő: Calibration study of a special in vitro measuring plate
37th OTDK, Technical Sciences Section, Environmental Engineering Sciences - 2nd place
Erdősi Rea: Impedance-based study of sensors for micro- and nanoplastics
PTE MIK TMDK CONFERENCE 2025 - 1st place
Veress Máté Noé: Application of a new impedance-based testing method on Pseudomonas aeruginosa biofilms
PTE ÁOK and GYTK Internal Scientific Student Conference Pécs, 2025 - 3rd place
Veress Máté Noé: Application of a new impedance-based testing method on Pseudomonas aeruginosa biofilms
Univesity of Pécs, Medical School, Dean's Thesis 2025 - 3rd place
Lili Nádasdi: Selective enhancement of the therapeutic sensitivity of tumour cells using electric field
Student Research Conference of the University of Pécs Medical School and of the Faculty of Pharmacy (Pécs, 2022), local round, III. place
