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A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

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Animal Imaging

  • Services
  • Members
  • Publications
Equipments

Bruker’s PharmaScan 4.7T MRI Scanner

The PharmaScan MR scanner is a modern, high field, easy-to-use system. It is designed for MRI applications on small animals such as rats and mice in the field of whole-body conventional, advanced functional, dynamic heart, and pharmaceutical imaging as well as for biomedical and molecular imaging research.



IVIS Lumina III (PerkinElmer)

Bioluminescent/fluorescent in vivo imaging enables the examination of the expression of proteins, receptors, and enzymes, production of free radicals in murine models. Luminescent imaging utilises either free radical-specific chemiluminescent substrates, or light emitted during the luciferase-luciferin enzyme reaction. During fluorescence imaging studies specific dyes and fluorescent probes are used. The instrument is capable of imaging in vivo (mice/rats), ex vivo (organ and tissue samples), or in vitro (e.g. cell cultures) samples.

Further informations about the instrument:

http://www.perkinelmer.com/Catalog/Product/ID/IVISLMIII



SkyScan 1176 Micro-CT (Bruker)

High resolution CT-imaging of anesthetized rodents (inbuilt cardiac and respiratory monitoring), excised organs, and tissue samples. Structural examination of various organic/inorganic materials is also possible. Enables long term follow-up of disease models in the same set of subjects. Particulary suitable for in vivo structural imaging studies (bone remodeling, lung architecture).

Further informations about the instrument:

http://www.skyscan.be/products/1176.htm



FMT 2000 (PerkinElmer)

The instrument is capable of monitoring diverse mouse disease models using dedicated fluorescent near-infrared contrast agents (excitation at 680 or 750 nm wavelengths). Possible areas of use are: inflammatory/tumor-induced vascular leakage, receptor expression pattern, inflammatory enzyme activity, bone remodeling, etc. The same set of mice can be examined repeatedly in a noninvasive manner. The instrument is capable of 3D reconstruction of fluorophore distribution, and absolute (picomolar) quantification of the amount of fluorescent probes. Combination of fluorescent tomographic and structural CT-scans (multimodal image reconstruction) is also possible.

Further informations about the instrument:

http://www.perkinelmer.com/Catalog/Product/ID/FMT2000



NIKON intravital microscope

With the aid of ex vivo or in vivo labeling techniques vascular responses and the movement of labeled immune cells can be visualized, quantified, and monitored in real time. The technique is suitable to examine the surface of organs in situ.

Further informations about the instrument:

http://nikon.com/products/instruments/lineup/bioscience/stereoscopic_microscopes/smz800n/index.htm



PeriCam laser speckle device (Perimed)

Continous visual monitoring and precise quantification of skin, joint, and brain microcirculation. Suitable for both preclinical models and clinical studies.

Further informations about the instruments:

http://www.perimed-instruments.com/products/pericam-psi

http://www.perimed-instruments.com/products/periflux-system-5000-ldpm

http://www.perimed-instruments.com/products/periscan-pim-3



PeriFlux 5000 Laser Doppler Flowmeter (Perimed)

Continous visual monitoring and precise quantification of skin, joint, and brain microcirculation. Suitable for both preclinical models and clinical studies.

Further informations about the instruments:

http://www.perimed-instruments.com/products/pericam-psi

http://www.perimed-instruments.com/products/periflux-system-5000-ldpm

http://www.perimed-instruments.com/products/periscan-pim-3



PeriScan PIM II laser doppler (Perimed)

Continous visual monitoring and precise quantification of skin, joint, and brain microcirculation. Suitable for both preclinical models and clinical studies.

Further informations about the instruments:

http://www.perimed-instruments.com/products/pericam-psi

http://www.perimed-instruments.com/products/periflux-system-5000-ldpm

http://www.perimed-instruments.com/products/periscan-pim-3



Dr. Ágnes Kemény
associate professor
kemenyagnes1@gmail.com
31636
Dr. Kata Bölcskei
assistant professor
kata.bolcskei@aok.pte.hu
31642
Dr. Angéla Kecskés
research fellow
angela.kecskes@aok.pte.hu
31642
Dr. Szilvia Nagy
research fellow
szilvia.anett.nagy@gmail.com
29227 mellék
Dr. Ádám István Horváth
assistant lecturer
hadam20@gmail.com
35404
Dr. Bálint Botz
resident
balint.botz@aok.pte.hu
0483
Dr. István Zoárd Bátai
assistant research fellow
istvanzbatai@gmail.com
35590
Dr. Gábor Kriszta
PhD student
gabor.kriszta@aok.pte.hu
29143
Dr. Ágnes Hunyady
PhD student
agnes.hunyady@gmail.com
31915
Tamás Kiss
assistant
kiss891012@gmail.com
29174

2020

Stress-induced microstructural alterations correlate with the cognitive performance of rats: A longitudinal in vivo diffusion tensor imaging study

Nagy SA, Vranesics A, Varga Zs, Csabai D, Bruszt N, Bali KZS et al. (2020)
Stress-induced microstructural alterations correlate with the cognitive performance of rats: A longitudinal in vivo diffusion tensor imaging study.
Front. Neurosci. doi: 10.3389/fnins.2020.00474. ahead of print

2019

Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice

Kriszta, G., Nemes, B., Sandor, Z., Acs, P., Komoly, S., Berente, Z., et al. (2019).
Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice.
Cells 9(1). doi: 10.3390/cells9010081.

Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging: A Rat Study

Toth, A., Berente, Z., Bogner, P., Kornyei, B., Balogh, B., Czeiter, E., et al. (2019).
Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging: A Rat Study.
J Neurotrauma 36(10), 1670-1677. doi: 10.1089/neu.2018.6004.

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Bátai, I. Z., Sár, C. P., Horváth, Á., Borbély, É., Bölcskei, K., Kemény, Á., Sándor, Z., Nemes, B., Helyes, Z., Perkecz, A., Mócsai, A., Pozsgai, G., & Pintér, E. (2019).
TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis. Frontiers in pharmacology, 10, 964.

2018

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide

Bátai, I. Z., Horváth, Á., Pintér, E., Helyes, Z., & Pozsgai, G. (2018).
Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide
and Dimethyl Trisulfide. Frontiers in endocrinology, 9, 55.
CONTACT
Dr. Zsuzsanna Helyes
Core Facility Leader
 +36 72 501 500 / 29043
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LINKS
Uplodaing...

Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging: A Rat Study

Toth, A., Berente, Z., Bogner, P., Kornyei, B., Balogh, B., Czeiter, E., et al. (2019).
Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging: A Rat Study.
J Neurotrauma 36(10), 1670-1677. doi: 10.1089/neu.2018.6004.

English

Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice

Kriszta, G., Nemes, B., Sandor, Z., Acs, P., Komoly, S., Berente, Z., et al. (2019).
Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice.
Cells 9(1). doi: 10.3390/cells9010081.

English

Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice

Bolcskei, K., Kriszta, G., Saghy, E., Payrits, M., Sipos, E., Vranesics, A., et al. (2018).
Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice.
J Neuroimmunol 320, 1-10. doi: 10.1016/j.jneuroim.2018.03.020.

English

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