About us

A Szentágothai János Kutatóközpont a PTE korszerű, nemzetközi tudományszervezési és menedzsment normák szerint kialakított új intézménye, amely az élettudományi, élettelen természettudományi, valamint környezettudományi oktatás...

Tovább

Bejelentkezés

CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Login


Genomics and Bioinformatics

  • Services
  • Members
  • Publications

The Genomics and Bioinformatics Core Facility is the first Hungarian core facility with special emphasis of providing services on both next generation sequencing (NGS) and bioinformatics.

Located in the Szentágothai Research Centre at the University of Pécs, it offers a broad range of NGS services, including Illumina sequencing (NextSeq, MiSeq, MiniSeq and iSeq), nanopore long-read sequencing (MinION), and full-service protocols for genome, transcriptome, epigenome and metagenome sequencing. The facility also offers advice on study design and provide bioinformatics and biostatistical data analysis services on NGS as well as other biomedical data.

Services

Library preparation and quality control

Tapestation 4200

The Genomics and Bioinformatics Facility offers a broad range of library preparation methods from DNA and RNA samples depending on the sequencing technology, sample source, and biological question of interest. At each step there is a careful quality check of each sequencing library prepared either by our facility staff members or the users. The major steps include:

  • Measurement of concentration (Fluorescence Qubit 4.0)
  • Measurement of size (Bioanalyzer 2100, TapeStation 4200)


Next generation sequencing

Sequencing is performed on Illumina (NextSeq 550, MiSeq, MiniSeq, iSeq) and Nanopore (MinION) sequencing instruments depending on the application and biological question. The available instruments cover short (Illumina technology) and long sequencing (Oxford Nanopore technology) as well as a broad range of output, from a few million to hundrends of millions reads.

NextSeq 550


Bioinformatics and data analyis

The facility provides bioinformatics services covering all the major steps of NGS data analysis, including data preprocessing (demultiplexing and transfer of unaligned BAM file), standard bioinformatic analysis (alignment and genome browser visualization of BAM file), downstream bioinformatic analysis (e.g. differential expression or genotype calling) as well as assistance with publication-related data sharing requirements (e.g. GEO submission).



Equipments

Covaris M220 Ultrasonicator

Covaris M220

M220 Focused-ultrasonicator is designed for Next Generation Sequencing applications requiring fragment sizes between 150bp and 5kb. Covaris AFA transmits acoustic energy at ultrasonic frequencies and very short wavelengths and is uniquely able to focus the energy into your sample. AFA controls the shearing forces that fragment nucleic acids to the selected size.



Illumina iSeq NGS

The iSeq destkop sequencer utilizes Illumina’s one-channel sequencing by synthesis technology to give extraordinarily fast sequencing turnaround while maintaining high data quality. Even as the smallest Illumina sequencer to-date, it is still able to produce over 1.2 billion base pairs in as little as 9 hours for a 50-bp single-read run. The iSeq is a flexible system with a wide range of applications that is ideal small genome sequencing, targeted and amplicon sequencing, and viral and microbial sequencing.

iSeq


Illumina MiniSeq

MiniSeq

The MiniSeq System provides high-quality sequencing technology with the cost-effective desktop system. It enables small genome, amplicon, targeted enrichment, and RNA sequencing using low library volume. It is ideal for targeted research applications like cancer sequencing and gene expression profiling.



Illumina MiSeq

The MiSeq benchtop instrument utilizes a double-sided, single-lane flow cell and reagent cartridge supplied in kit form. It performs both single- and paired-end runs with adjustable read lengths from 1 x 36 base pairs to 2 x 300 base pairs. MiSeq is also a cost-effective tool for various analyses focused on targeted gene sequencing (amplicon sequencing or target enrichment), metagenomics, and gene expression studies.

MiSeq


Illumina NextSeq 550 NGS

NextSeq 550

The NextSeq 550 System offers the right sequencer for various project sizes and sequencing throughputs, providing users with optimal operational efficiency. This fast, flexible, high-throughput benchtop sequencer enables transcriptome and targeted resequencing applications with the accuracy of Illumina sequencing technology. With the ability to switch between lower and higher run configurations based on a project’s needs, the NextSeq 550 is the ideal platform for small to medium sequencing projects that range in output requirements.



Oxford Nanopore MinION sequencer

MinION is a portable, real-time device for DNA and RNA sequencing, putting you in control of your sequence data. Using nanopore sequencing, a single molecule of DNA or RNA can be sequenced without the fragmentation, the need for PCR amplification or chemical labeling of the sample. Ultra-long read lengths are possible (hundreds of kb) as you can choose your fragment length.

Nanopore MinIon


TapeStation 4200 system

Tapestation 4200

 

The Agilent 4200 TapeStation system is intended to separate nucleic acids by means of electrophoresis. This instrument is a complete solution for true end-to-end sample QC within any NGS workflow covering the full DNA and RNA sizing range. Depending on your application, the software automatically determines size, quantity, purity, RNA and DNA integrity.

 



ABI Prism 310 Genetic Analyzer

The ABI PRISM® 310 sequencer is an automated single-capillary genetic analyzer designed for a wide range of sequencing and fragment analysis applications. Perform comparative sequencing, linkage analysis, STR analysis, SNP detection, discovery and validation, mutation detection, and many other applications. The sequencer detect five dyes simultaneously to increase throughput. The average test time for a sample is one and a half hours.



Applied Biosystems StepOnePlus™

The StepOnePlus™ Real-Time PCR System is a 96-well Real-Time PCR instrument perfect for both first-time and experienced users. The StepOnePlus™ Real-Time PCR System can be setup in a variety of configurations and comes ready to use, out of the box, with intuitive data analysis and instrument control software. Utilizing robust LED based 4-color optical recording, the StepOnePlus™ Real-Time PCR System is designed to deliver precise, quantitative Real-Time PCR results for a variety of genomic research applications. The StepOnePlus™ Real-Time PCR System has an innovative Applied Biosystems VeriFlex Block for convenient PCR optimization.

www.thermofisher.com/hu/en/home/life-science/pcr/real-time-pcr/real-time-pcr-instruments/step-one-real-time-pcr-systems.html#

 



Bio-Rad CFX96 Touch DeepWell Real Time PCR

CFX Real-Time PCR Detection Systems are powerful and flexible instruments, featuring 2–5 color multiplexing, advanced optical technology, and precise temperature control with thermal gradients. These systems deliver sensitive, reliable detection of both singleplex and multiplex real-time PCR reactions. Paired with CFX Maestro Analysis Software, CFX Instruments provide superior data collection, statistical analysis, and data visualization capabilities.

Bio-Rad cfx96


Hitachi CR22GIII centrifuga

With the high capacity floor standing Hitachi centrifuge, maximum 6 L (4x1500 ml) can be centrifuged. The centrifuge can be operated easily with the help of an LCD touchscreen, and all the important parameter can be controlled and followed during centrifugation. Maximum speed is 22.000 rpm.

http://www.ibiotech.cz/media/files/product_pdf/cn22n.pdf

 



nCounter SPRINT Profiler

The nCounter SPRINT Profiler employs a novel digital barcode technology that hybridizes to target molecules. Each unique digital barcode is then directly counted using a single molecule imaging technique to yield precise and sensitive quantification. Up to 800 targets can be measured simultaneously in a single sample, and up to 12 samples can be assayed in a single run.

https://www.nanostring.com/products/ncounter-systems-overview/ncounter-sprint-profiler

The following nCounter applications are supported on the SPRINT Profiler:

  • Gene expression (mRNA)
  • miRNA
  • DNA copy number variation (CNV)
  • lncRNA
  • DNA enriched by chromatin-immunoprecipitation (ChIP-String)
  • Protein
  • Gene fusions


Useful Information

Usage policy and facility access

The Genomics and Bioinformatics facility offers access to its services to all Hungarian academic and industrial research groups. Free capacity is offered to other external users (academic and industry) of other countries. To estimate feasibility and allocable resources, we strongly recommend contacting our team when planning a sequencing experiment or bioinformatics data analysis task.

 

Acknowledging the facility

Continuation of funding for the Genomics and Bioinformatics facility by the University of Pécs as well as the Hungarian and European funding agencies depends on documented evidence of contribution to scientific output. We therefore require acknowledgement of use of the facility in published work. A simple statement is sufficient and can either be placed in the Materials and Methods section or at the end of your manuscript (acknowledgements) depending on the journal format, such as:

Next generation sequencing and/or bioinformatics data analysis services were performed by the Genomics and Bioinformatics Core Faciity of the Szentágothai Research Centre at the University of Pécs.” Your publication will be also listed on our website.

Dr Attila Gyenesei
senior research fellow
gyenesei.attila@pte.hu
Dr. József Kun
research fellow
kun.jozsef@pte.hu
29202
Dr. Róbert Herczeg
research fellow
herczeg.robert@pte.hu
Péter Urbán
assistant research fellow
urban.peter@pte.hu
29291
Bence Gálik
assistant research fellow
galik.bence@pte.hu
Witold Bauer
assistant research fellow
bauer.witold@pte.hu
Mónika Mátyás
project assistant
matyas.monika@pte.hu
29202
Réka Zsiborás
laboratory assistant
zsiboras.reka@pte.hu
29291
Adrienn Harangozó-Dimák
laboratory assistant
dimak.adrienn@pte.hu
29291

2021

Publications

  • Schvarcz, C.A.; Danics, L.; Krenács, T.; Viana, P.; Béres, R.; Vancsik, T.; Nagy, Á.; Gyenesei, A.; Kun, J.; Fonović, M.; Vidmar, R.; et al.: Repeated Modulated Electro‐Hyperthermia Induces a Prominent Local Stress Response and Growth Inhibition in Triple Negative Mouse Breast Cancer Isografts. Cancers 2021, 13, 1744. https://doi.org/10.3390/ cancers13071744

  • Kraboth, Z.; Kajtár, B.; Gálik, B.; Gyenesei, A.; Miseta, A.; Kalman, B. Involvement of the Catecholamine Pathway in Glioblastoma Development. Cells 2021, 10, 549. https://doi.org/10.3390/cells10030549
  • Szabo, D.; Sarszegi, Z.; Polgar, B.; Saghy, É.; Nemeth, A.; Reglodi, D.; Makkos, A.; Gorbe, A.; Helyes, Z.; Ferdinandy, P.; et al.: PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study. International Journal of Moecular  Sciences 2021, 22, 2883. https://doi.org/10.3390/ijms22062883 
  • Gombos K., Gálik B.,Kalács K.I., Gödöny K., Várnagy Á., Bódis J., Alpár D., Gyenesei A., Kovács. L.G. : NGS-based pipeline for routine non-invasive pre-implantation genetic assessment in IVF, International Journal of Molecular Sciences, 2021, 22, 2443  https://doi.org/10.3390/ijms22052443

2020

Publications

  • Gombos K., Földi M., Kiss Sz., herczeg R., Gyenesei A., Geiger L., Csabai D., Futács K., Nagy T., Miseta A., Somogyi B.A., hegyi P., Szentesi A. : Analysis of COVID-19-related RT-qPCR test results in Hungary: Epidemology, dianostics and clinical outcome . Frontiers in Medicine, 2020
  • Kemenesi, G.; Zeghbib, S.; Somogyi, B.A.; Tóth, G.E.; Bányai, K.; Solymosi, N.; Szabo, P.M.; Szabó, I.; Bálint, Á.; Urbán, P.; Herczeg, R.; Gyenesei, A.; Nagy, Á.; Pereszlényi, C.I.; Babinszky, G.C.; Dudás, G.; Terhes, G.; Zöldi, V.; Lovas, R.; Tenczer, S.; Kornya, L.; Jakab, F.: Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix. Viruses 2020, 12, 1401.
  • Gombos K, Herczeg R, Erőss B, Kovács S Zs, Uzzoli A, Nagy T, Kiss Sz, Szakács Zs, Imrei M, Szentesi A, Nagy A, Fábián A, Hegyi P, Gyenesei A : Translating Scientific Knowledge to Government Decision Makers Has Crucial Importance in the Management of the COVID-19 Pandemic. Population Health Management 2020 SEP 2 doi: 10.1089/pop.2020.0159
  • Kecskés A, Pohóczky  K, Kecskés  M, , Varga  V.Z, Kormos V, Szőke É, Henn-Mike N, Fehér M, Kun J, Gyenesei A, Renner É, Palkovits M, Ferdinandy P, Ámrahám M. I, Gaszner B, Helyes Zs: Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains. International Journal of Molecular Sciences, 202021(20), 7788; https://doi.org/10.3390/ijms21207788 
     
  • Salgado D, Armean IM, Baudis M et al.:  The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research [version 1; peer review: awaiting peer review]. F1000Research 2020, 9(ELIXIR):1229 (https://doi.org/10.12688/f1000research.24887.1)
     
  • Krabóth Z., Gálik B.,Tompa M., Kajtár B., Urbán P., Gyenesei, A., Miseta, A., Kálmán, B. : DNA CpG methylation in sequential glioblastoma specimens. Journal of Cancer Research and Clinical Oncology 2020 Aug 10. https://doi.org/10.1007/s00432-020-03349-w
  • Gángó A, Alpár D, Galik B, Marosvári D, Kiss R, Fésüs V, Aczél D, Eyüpoglu E, Nagy N, Nagy Á, Krizsán S, Reiniger L, Farkas P, Kozma A, Ádám E, Tasnády S, Réti M, Matolcsy A, Gyenesei A, Mátrai Z, Bödör C. Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib. Int J Cancer. 2020 Jan 1;146(1):85-93. doi: 10.1002/ijc.32502.
     
  • Montgomery SA, Tanizawa Y, Galik B, Wang N, Ito T, Mochizuki T, Akimcheva S, Bowman JL, Cognat V, Maréchal-Drouard L, Ekker H, Hong SF, Kohchi T, Lin SS, Liu LD, Nakamura Y, Valeeva LR, Shakirov EV, Shippen DE, Wei WL, Yagura M, Yamaoka S, Yamato KT, Liu C, Berger F. :Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin. Current Biology 2020 Feb 24;30(4):573-588.e7. doi: 10.1016/j.cub.2019.12.015. 
     
  • Bödör C, Alpár D, Marosvári D, Galik B, Rajnai H, Bátai B, Nagy Á, Kajtár B, Burján A, Deák B, Schneider T, Alizadeh H, Matolcsy A, Brandner S, Storhoff J, Chen N, Liu M, Ghali N, Csala I, Bagó AG, Gyenesei A, Reiniger L. : Molecular Subtypes and Genomic Profile of Primary Central Nervous System Lymphoma. Journal of Neuropathology & Experimental Neurology 2020 Feb 1;79(2):176-183. doi:10.1093/jnen/nlz125.
     
  • Csepregi R, Temesfői V, Das S, Alberti Á, Tóth CA, Herczeg R, Papp N, Kőszegi T. :Cytotoxic, Antimicrobial, Antioxidant Properties and Effects on Cell Migration of Phenolic Compounds of Selected Transylvanian Medicinal Plants. Antioxidants (Basel). 2020 Feb 18;9(2):166. doi: 10.3390/antiox9020166. 
     
  • Paczkowska-Abdulsalam M, Niemira M, Bielska A, Szałkowska A, Raczkowska BA, Junttila S, Gyenesei A, Adamska-Patruno E, Maliszewska K, Citko A, Szczerbiński Ł, Krętowski A. : Evaluation of Transcriptomic Regulations behind Metabolic Syndrome in Obese and Lean Subjects. International Journal of Molecular Sciences 2020 Feb 20;21(4):1455. doi:10.3390/ijms21041455.
     
  • Fodor, István ; Zrinyi, Zita ; Urbán, Péter ; Herczeg, Robert ; Büki, Gergely ; M. Koene, Joris ; Tsai, Pei-San ; Pirger, Zsolt: Identification, presence, and possible multifunctional regulatory role of invertebrate gonadotropin-releasing hormone/corazonin molecule in the great pond snail (Lymnaea stagnalis)2020 doi: 10.1101/2020.03.01.971697
     
  • Madai M, Németh V, Oldal M, Horváth G, Herczeg R, Kelemen K, Kemenesi G, Jakab F. :Temporal Dynamics of Two Pathogenic Hantaviruses Among Rodents in Hungary. Vector-Borne and Zoonotic Diseases. 2020 Mar;20(3):212-221. doi: 10.1089/vbz.2019.2438.
     
  • Aczél T, Kecskés A, Kun J, Szenthe K, Bánáti F, Szathmary S, Herczeg R, Urbán P, Gyenesei A, Gaszner B, Helyes Z, Bölcskei K. : Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization. International Journal of Molecular Sciences 2020 Apr 22;21(8):2938. doi: 10.3390/ijms21082938. 
     
  • Papp H, Zeghbib S, Földes F, Banfai K, Madai M, Kemenesi G, Urbán P, Kvell K, Jakab F. :Crimean-Congo hemorrhagic fever virus infection triggers the upregulation of the Wnt signaling pathway inhibitor genes. Virus Genes 2020 Apr 25. doi: 10.1007/s11262-020-01759-z. 
     
  • Friston D, Junttila S, Lemes JBP, Laycock H, Torres-Perez JV, Want E, Gyenesei A, Nagy I.:  Leptin and fractalkine: novel subcutaneous cytokines in burn injury. Disease Models & Mechanisms 2020 Apr 29;13(4):dmm042713. doi: 10.1242/dmm.042713.
     
  • Kemenesi G, Kornya L, Tóth GE, Kurucz K, Zeghbib S, Somogyi BA, Zöldi V, Urbán P, Herczeg R, Jakab F. :Nursing homes and the elderly regarding the COVID-19 pandemic: situation report from Hungary. Geroscience. 2020 May 18:1-7. doi: 10.1007/s11357-020-00195-z. 
     
  • Fodor I, Urbán P, Kemenes G, Koene JM, Pirger Z. :Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases. Invertebrate Neuroscience 2020 May 24;20(3):9. doi: 10.1007/s10158-020-00242-6. 
     
  • Bodis J, Gödöny K, Várnagy Á, Kovács K, Koppán M, Nagy B, Erostyák J, Herczeg R, Szekeres-Barthó J, Gyenesei A, Kovács GL.:  How to reduce the potential harmful effects of light on blastocyst development during IVF. Medical Principles and Practice 2020 May 29. doi: 10.1159/000509016. 

2019

Publications

  • Marik T, Tyagi C, Balázs D, Urbán P, Szepesi Á, Bakacsy L, Endre G, Rakk D, Szekeres A, Andersson M A, Salonen H, Druzhinina I S, Vágvölgyi Cs, Kredics L. Structural Diversity and Bioactivities of Peptaibol Compounds From the Longibrachiatum Clade of the Filamentous Fungal Genus Trichoderma. Frontiers in Microbiology, 2019. Accepted for publication. Doi: 10.3389/fmicb.2019.01434. IF: 4.26
     
  • Garai K, Ádam Z, Herczeg R, Katai E, Nagy T, Pál Sz., Gyenesei A, Pongracz J, Wilhelm M, Kvell K. Artificial neural network correlation and biostatistics evaluation of physiological and molecular parameters in healthy young individuals performing regular exercise. Frontiers in Physiology, 2019. Accepted for publication. IF: 3.2
     
  • Péterfalvi A, Németh N, Herczeg R, Tényi T, Miseta A, Czéh B, Simon M. Examining the Influence of Early Life Stress on Serum Lipid Profiles and Cognitive Functioning in Depressed Patients. Frontiers in Psychology 2019. Accepted for publication. https://doi.org/10.3389/fpsyg.2019.01798, IF: 2.13
     
  • Macsai L, Olah Z, Bush AI, Galik B, Onody R, Kalman J, Datki Z. :Redox Modulating Factors Affect Longevity Regulation in Rotifers.  The Journals of Gerontology Series A Biological Sciences and Medical Sciences 2019 May 16;74(6):811-814. doi: 10.1093/gerona/gly193.
     
  • Gángó A*, Alpár D*, Gálik B*, Marosvári D, Kiss R, Fésüs V, Aczél D, Eyüpoglu E, Nagy N, Nagy Á, Krizsán S, Reiniger L, Farkas P, Kozma A, Ádám E, Tasnády S, Réti M, Matolcsy A, Gyenesei A, Mátrai Z, Bödör C. Dissection of Subclonal Evolution by Temporal Mutation Profiling in Chronic Lymphocytic Leukemia Patients Treated With Ibrutinib. International Journal of Cancer 2019 Jun 10. Doi: 10.1002/ijc.32502. IF: 7.36
     
  • Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A*, Ilonen J*. Age at Seroconversion, HLA Genotype and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood. Journal of Clinical Endocrinology & Metabolism 2019 May 23. pii: jc.2019-00421. doi: 10.1210/jc.2019-00421. IF: 5.79
     
  • Zana B, Geiger L, Kepner A, Földes F, Urbán P, Herczeg R, Kemenesi G, Jakab F. First molecular detection of Apis mellifera filamentous virus in honey bees ( Apis mellifera ) in Hungary, Acta Veterinaria 2019, 67:1 pp. 151-157. IF: 1.04
     
  • Montskó, G ; Gödöny, K ; Herczeg, R ; Várnagy, Á ; Bódis, J ; Kovács, GL Alpha-1 chain of human haptoglobin as viability marker of in vitro fertilized human embryos: information beyond morphology. System Biology in Reproductive Medicine 2019, 65: 2 pp. 174-180, IF: 1.58
  • Datki Z, Galik-Olah Z, Bohar Z, Zadori D, Fulop F, Szatmari I, Galik B, Kalman J, Vecsei L. : Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers. Molecules. 2019 Jun 10;24(11):2171. doi.:10.3390/molecules24112171. 
  • Aczél T, Kun J, Szőke É, Rauch T, Junttila S, Gyenesei A, Bölcskei K, Helyes Zs. Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model. Frontiers in Molecular Neuroscience 2018. Doi: 10.3389/fnmol.2018.00219. IF: 3.90
  • Zana B, Kemenesi G, Buzás D, Csorba G, Görföl T, Khan FAA, Tahir NFDA,Zeghbib S, Madai M, Papp H, Földes F, Urbán P, Herczeg R, Tóth GE, Jakab F.: Molecular Identification of a Novel Hantavirus in Malaysian Bronze Tube-Nosed Bats (Murina aenea) Viruses. 2019 Sep 21;11(10):887. doi:10.3390/v11100887. 
  • Földes F, Madai M, Németh V, Zana B, Papp H, Kemenesi G, Bock-Marquette I,Horváth G, Herczeg R, Jakab F. : Serologic survey of the Crimean-Congo haemorrhagic fever virus infection among wild rodents in Hungary. Ticks Tick-borne Diseases. 2019 Oct;10(6):101258. doi: 10.1016/j.ttbdis.2019.07.002.
  • Zeghbib S, Herczeg R, Kemenesi G, Zana B, Kurucz K, Urbán P, Madai M, Földes F, Papp H, Somogyi B, Jakab F.: Genetic characterization of a novel picornavirus in Algerian bats: co-evolution analysis of bat-related picornaviruses. Scientific Reports 2019 Oct 31;9(1):15706. doi: 10.1038/s41598-019-52209-2.
  • Bödör C, Alpár D, Marosvári D, Galik B, Rajnai H, Bátai B, Nagy Á, Kajtár B, Burján A, Deák B, Schneider T, Alizadeh H, Matolcsy A, Brandner S, Storhoff J, Chen N, Liu M, Ghali N, Csala I, Bagó AG, Gyenesei A, Reiniger L. Molecular Subtypes and Genomic Profile of Primary Central Nervous System Lymphoma. J Neuropathol Exp Neurol. 2019 Nov 28. doi: 10.1093/jnen/nlz125. 

     

2018

Publications

  • Mutti M, Sonnevend Á, Pál T, Junttila S, Ekker H, Galik B, Gyenesei A, Nagy G, Nagy E, Szijártó V. : Complete Genome Sequence of Escherichia coli 81009, a Representative of the Sequence Type 131 C1-M27 Clade with a Multidrug- Resistant Phenotype. Genome Announcements. 2018 doi: 10.1128/genomeA.00056-18. 
  • Aczél T, Kun J, Szőke É, Rauch T, Junttila S, Gyenesei A, Bölcskei K, Helyes Z. : Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model. Frontiers in Molecular Neuroscience 2018 doi: 10.3389/fnmol.2018.00219. 
  • Datki Z, Olah Z, Hortobagyi T, Macsai L, Zsuga K, Fulop L, Bozso Z, Galik B, Acs E, Foldi A, Szarvas A, Kalman J. :Exceptional in vivo catabolism of neurodegeneration-related aggregates.  2018 Jan 29;6(1):6. doi: 10.1186/s40478-018-0507-3. 
  • Bán Á, Pintér E, Kun J. :A megfelelő szájegészség megvédhet a kalciumcsatorna- blokkoló készítmények okozta gingivahyperplasia kialakulásától [Proper oral health can protect from developing gingival hyperplasia induced by calcium channel blockers]. Orvosi Hetilap 2018 Jul;159(29):1183-1187. Hungarian. doi: 10.1556/650.2018.31088. 
  • Feller D, Kun J, Ruzsics I, Rapp J, Sarosi V, Kvell K, Helyes Z, Pongracz JE. : Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines. Frontiers in Immunology. 2018 Jul 25;9:1724. doi: 10.3389/fimmu.2018.01724. 
  • Deutsch-Nagy L, Urbán P, Tóth Z, Bihari Z, Kocsis B, Fekete C, Kilár F. : Genome sequence of Shigella sonnei 4303. Gut Pathogens 2018 Oct 24;10:47. doi: 10.1186/s13099-018-0274-5. 
CONTACT
Dr Attila Gyenesei
Core Facility Leader
 
DOWNLOADS
LINKS
Facebook

Publications

  • Schvarcz, C.A.; Danics, L.; Krenács, T.; Viana, P.; Béres, R.; Vancsik, T.; Nagy, Á.; Gyenesei, A.; Kun, J.; Fonović, M.; Vidmar, R.; et al.: Repeated Modulated Electro‐Hyperthermia Induces a Prominent Local Stress Response and Growth Inhibition in Triple Negative Mouse Breast Cancer Isografts. Cancers 2021, 13, 1744. https://doi.org/10.3390/ cancers13071744

English

Pages

Subscribe to RSS - Genomics and Bioinformatics